Results 181 to 190 of about 1,044,908 (274)

Companion Diagnostics in Clinical Therapy: Current Applications and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Companion diagnostics use biomarker‐based assays to stratify patients for precision therapies, improving outcomes while reducing ineffective treatment and side effects. This review summarizes the evolution, regulatory landscape, clinical applications, and technological platforms of CDx, highlighting their role in biomarker‐driven precision therapy.
Yuesong Wu, Rou Xue, Xiangwen Luo, Jiangnan Liao, Zongbo Zhang, Jinhai Deng, Teng Liu, Xin Li, Zhe‐Sheng Chen, Mingzhu Yin   +9 more
wiley   +1 more source

Correction: Tumor organoids may be more suitable for clinical personalized chemotherapeutic drug screening in lung adenocarcinoma. [PDF]

Front Cell Dev Biol
Yun W, Li Y, Ge Y, Zhang X, Liu H, Chen W, Xiao L.   +6 more
europepmc   +1 more source

Clinical Application of Peripheral Blood Biomarkers for Solid Tumors

MedComm, Volume 7, Issue 3, March 2026.
Peripheral blood biomarkers provide a minimally invasive, dynamic, and potentially more accurate means to obtain a comprehensive tumor profile. Technologies for detecting them are advancing, and with the help of artificial intelligence, they are being used more and more often for cancer diagnosis, prognostic assessment, and therapeutic monitoring ...
Xinru Tu, Mengyan Tu, Junfen Xu
wiley   +1 more source

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Development and Transformation of Veterinary Experimental In Vitro Models: From 2D Culture to 3D Organoids. [PDF]

Animals (Basel)
Hu X, Xie Y, Wang J, Zhang X, Wu R.
europepmc   +1 more source

MicroRNAs in Methamphetamine: Addiction, Neurotoxicity, and Therapeutic Potential

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
The use of METH leads to the release of dopamine from the affected brain regions, including the nucleus accumbens (NAc), ventral tegmental area (VTA), prefrontal cortex (PFC), hippocampus (Hip), and striatum. This triggers signals that alter miRNA expression, which in turn leads to differential expression of target genes.
Yacoubou Abdoul Razak Mahaman, An‐Ping Ye, Ya‐Xian Zhang, Ming‐Yu Chen, Fang Huang, Rong Liu, Ying‐Yan Fang, Xiaochuan Wang   +7 more
wiley   +1 more source

Brain organoids as precision models for neurodegenerative diseases: from disease modeling to drug discovery. [PDF]

Front Neurosci
Zheng Y, Zhou W, Chang H, Zheng K.
europepmc   +1 more source

Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen, Jingtian Yu, Wuqiang Wen, Baishan Jiang   +3 more
wiley   +1 more source

AI and organoid platforms for brain-targeted theranostics. [PDF]

Theranostics
Ye R, Zhang Y, Xu W, Lai L, Zhang Z, Chen Y, Qin S.   +6 more
europepmc   +1 more source

Advance Microbiota Transplantation: A Novel Addition–Subtraction Paradigm for Optimising Faecal Microbiota Transplantation

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
This review proposes Advance Microbiota Transplantation (AMT), a pre‐peri‐post transplant ‘addition–subtraction’ framework that integrates donor–recipient optimisation, product engineering, and post‐transplant recipient adjuvant management to enhance conventional FMT efficacy and mitigate its limitations. ABSTRACT Faecal microbiota transplantation (FMT)
Haojia Lin, Zelin Feng, Qiuyue Tu, Huizhen Li, Yanru Zhang, Xinyue Wei, Qinghua Yi, Hetong Zhang, Yu Wang, Xiaoqin Li, Yueting Li, Jun Huang, Zehan Chen, Hongtian Shentu, Anjiang Wang, Ye Chen, Xiaolong He, Xiaocang Cao   +17 more
wiley   +1 more source