Results 151 to 160 of about 112,967 (355)

Generation of an isogenic iPSC line via CRISPR correction of the POMC:W84X mutation for monogenic obesity modeling

Stem Cell Research
We report the generation of a genetically corrected induced pluripotent stem cell (iPSC) line, BIHi261-A-1, derived from the patient-specific iPSC line BIHi261-A carrying a homozygous truncating mutation in the POMC gene (POMC:W84X). This mutation causes
Katarzyna A. Ludwik, Valeria Fernandez Valone, Regina Jahn, Sabine Jyrch, Lara Lechner, Peter Kühnen, Harald Stachelscheid   +6 more
doaj   +1 more source

Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo. [PDF]

, 2015
BackgroundThe mammary glands of pigs share many functional and morphological similarities with the breasts of humans, raising the potential of their utility for research into the mechanisms underlying normal mammary function and breast carcinogenesis ...
Borowsky, AD, Cardiff, RD, Hovey, RC, Manjarin, R, Rowson-Hodel, AR, Trott, JF   +5 more
core  

Biphasic Electrical Field Stimulation Aids in Tissue Engineering of Multicell-Type Cardiac Organoids [PDF]

, 2008
Loraine L. Y. Chiu, R. Iyer, John-Paul King, Milica Radisic   +3 more
openalex   +1 more source

Engineering Volumetric Tissue Analogs via Assembly of Endothelial Cell‐Covered Spheroidal Microtissues

Advanced Healthcare Materials, EarlyView.
An engineering strategy to fabricate highly vascularized volumetric tissues with capillary networks is developed. Endothelial cell‐covered spheroidal microtissues with high structural integrity are efficiently produced using bioprinting technology. These spheroidal microtissues are then assembled and cultured under perfusion conditions, resulting in ...
Hyeongkwon Oh, Jae‐Hun Kim, Sunwoo Lee, Jin‐Hyung Shim, Won‐Soo Yun, Songwan Jin   +5 more
wiley   +1 more source

Generation of human induced pluripotent stem cell line from an obesity patient with POMC deficiency due to POMC:W84X mutation

Stem Cell Research
We generated the human induced pluripotent stem cell (iPSC) line BIHi261-A from dermal fibroblasts of a patient with severe early-onset obesity caused by a homozygous truncating mutation in the POMC gene (W84X).
Katarzyna A. Ludwik, Regina Jahn, Sabine Jyrch, Lara Lechner, Valeria Fernandez Valone, Peter Kühnen, Harald Stachelscheid   +6 more
doaj   +1 more source

Detection of Epithelial‐Cell Injury, and Quantification of Infection, in the HCT‐8 Organoid Model of Cryptosporidiosis [PDF]

, 2008
Cirle A. Warren, Raul V. Destura, Jesus Emmanuel Sevilleja, Luis F. Barroso, Humberto M. Carvalho, Leah J. Barrett, Alison D. O’Brien, Richard L. Guerrant   +7 more
openalex   +1 more source

Granular Hydrogels as Modular Biomaterials: From Structural Design to Biological Responses

Advanced Healthcare Materials, EarlyView.
Granular hydrogels are now emerging as promising biomaterials due to their inherent microporousity, injectability, and modularity. They have shown improvements in cell viability and migration, cellular/tissue infiltration, host tissue integration, mitigated foreign body response, and tissue regeneration.
Asmasadat Vaziri, Renata Maia, Pei Zhang, Liliana Agresti, Jelmer Sjollema, Mohammad‐Ali Shahbazi, Hélder A. Santos   +6 more
wiley   +1 more source

Three-Dimensional Culture Systems in Neuroblastoma Research

Organoids
Basic and translational cancer biology research requires model systems that recapitulate the features of human tumors. While two-dimensional (2D) cell cultures have been foundational and allowed critical advances, they lack the organizational complexity,
Piotr Jung, Adam J. Wolpaw
doaj   +1 more source

Brain organoids and insights on human evolution. [PDF]

, 2019
Human brain organoids, generated from pluripotent stem cells, have emerged as a promising technique for modeling early stages of human neurodevelopment in controlled laboratory conditions.
Muotri, Alysson R
core  

Engineering of an Hepatic Organoid to Develop Liver Assist Devices [PDF]

, 2010
Alejandro Soto–Gutiérrez, Nalu Navarro–Álvarez, Hiroshi Yagi, Yakoov Nahmias, Martin L. Yarmush, Naoya Kobayashi   +5 more
openalex   +1 more source