Results 221 to 230 of about 112,967 (355)

FBXO44 Regulates FOXP1 Degradation Through AURKA‐Dependent Phosphorylation to Promote Colorectal Cancer Progression

Advanced Science, EarlyView.
FBXO44 promotes colorectal cancer progression by targeting FOXP1 for ubiquitin‐mediated degradation. This study reveals a phosphorylation‐dependent mechanism involving AURKA and highlights the FBXO44/FOXP1/Cyclin E2 axis as a potential therapeutic target in colorectal cancer.
Hongxu Nie, Hengjie Xu, Sheng Yang, Chuanxin Tian, Tuo Wang, Chi Jin, Zhihao Chen, Xiaowei Wang, Junwei Tang, Yifei Feng, Yueming Sun   +10 more
wiley   +1 more source

Recent Insights into Organoid-Derived Extracellular Vesicles and Their Biomedical Applications. [PDF]

J Pers Med
Abdal Dayem A, Kwak Y, Jeun H, Cho SG.
europepmc   +1 more source

Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids

, 2014
Sabina Lukovac, Clara Belzer, Linette Pellis, Bart J. F. Keijser, Willem M. de Vos, R.C. Montijn, Guus Roeselers   +6 more
openalex   +1 more source

Neural organoids for disease phenotyping, drug screening and developmental biology studies [PDF]

, 2016
Brigham J. Hartley, Kristen Brennand
openalex   +1 more source

Skullcapflavone II Inhibits SLC1A4‐Mediated L‐Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer

Advanced Science, EarlyView.
Skullcapflavone II (SkII) significantly alters serine metabolism in gastric cancer cells by directly targeting the L‐serine transporter SLC1A4, thereby inhibiting L‐serine uptake rather than de novo synthesis. This disruption of serine metabolism by SkII leads to increased oxidative stress and consequent mitochondrial damage.
Jing Zhao, Yu‐Bo Ma, Rui‐Hong Xia, Zheng‐Chen Jiang, Ying Zhou, Ya‐Nan Wang, Meng‐Yan Yang, Jing‐Jie Dai, Tao Zhu, Li‐Bin Pan, Li Yuan   +10 more
wiley   +1 more source

Capturing disease severity in LIS1-lissencephaly reveals proteostasis dysregulation in patient-derived forebrain organoids. [PDF]

Nat Commun
Zillich L, Gasparotto M, Rossetti AC, Fechtner O, Maillard C, Hoffrichter A, Zillich E, Jabali A, Marsoner F, Artioli A, Wilkens R, Schroeter CB, Hentschel A, Witt SH, Melzer N, Meuth SG, Ruck T, Koch P, Roos A, Bahi-Buisson N, Francis F, Ladewig J.   +21 more
europepmc   +1 more source

Lnc‐HZ05 Suppresses Trophoblast Cell Migrasome Formation by Disrupting TGFβ2 Pathway in Unexplained Recurrent Miscarriage

Advanced Science, EarlyView.
TGFβ2 signaling‐mediated migration/invasion and migrasome formation are suppressed in recurrent miscarriage (RM) versus healthy control villous tissues and are negatively associated with unexplained RM. In mechanism, TGFβ2 promotes trophoblast cell migration/invasion and migrasome formation, all of which are suppressed by lnc‐HZ05. In details, lnc‐HZ05
Weina Chen, Ying Zhang, Zimeng Zhao, Yang Yang, Geng Guo, Yi Sun, Tao Zhang, Zhihong Zhang, Liqin Zeng, Wenxin Huang, Qingjun Shen, Ruining Han, Zhaohui He, Depeng Zhao, Huidong Zhang   +14 more
wiley   +1 more source

Vascularizing the brain organoids

Journal of Molecular Cell Biology, 2022
Xin-Yao Sun, Zhen-Ge Luo
openaire   +2 more sources

Head and neck cancer organoids: a panoramic perspective from basic construction to clinical translation. [PDF]

Stem Cell Res Ther
Meng R, Yu L, Li X, Ning N, Hao H, Zhang X, Kong J, Song W, Li X.   +8 more
europepmc   +1 more source

Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse small intestine

, 2014
Sean R. Moore, Jill Pruszka, Jefferson E. Vallance, Eitaro Aihara, Toru Matsuura, Marshall H. Montrose, Noah F. Shroyer, Christian I. Hong   +7 more
openalex   +1 more source