Results 251 to 260 of about 120,310 (351)

Self-Organizing Ovarian Somatic Organoids Preserve Cellular Heterogeneity and Reveal Cellular Contributions to Ovarian Aging. [PDF]

Aging Cell
Dipali SS, Converse A, Gowett MQ, Kamat P, Zaniker EJ, Fennell A, Chou T, Pritchard MT, Zelinski M, Phillip JM, Duncan FE.   +10 more
europepmc   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

Host-membrane lipid composition controls <i>Cryptococcus neoformans</i> cellular targets. [PDF]

Front Immunol
Ramesh AI, Hegde S, Dabhi AM, Krishnamurthy S, Chandran D, Reddy SK, Yegneswaran PP, Saravu K, Mallikarjuna PV, Shettigar KS, Bhat P, Bhat V, Sabitha KR, Mariappan I, Aimanianda V, Shetty AK, Upadhya D.   +16 more
europepmc   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Organoid-based drug screening identifies homoharringtonine as a therapeutic agent for anaplastic thyroid cancer via TFEB-mediated lysosomal dysfunction. [PDF]

Cell Oncol (Dordr)
Zhang X, Li Z, Liu J, Huang R.
europepmc   +1 more source

Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis [PDF]

Babajide Ojo, Lyong Heo, Sejal R. Fox, Amanda Waddell, Maria E. Moreno‐Fernandez, Marielle Gibson, Tracy S. Tran, Ashley Dunn, Essam A. Elknawy, Neetu Saini, Javier A. López-Rivera, Senad Divanovic, Vinicio de Jesús Pérez, Michael Rosen   +13 more
openalex   +1 more source

TMEM131‐Mediated Soluble TRAIL Triggered Type II Alveolar Epithelial Cell Senescence in Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han, Chunsheng Wang, Xiuli Guo, Yuan Luo, Jianguo Zhang, Fajian He, Zihang Zeng, Jiang Luo, Wen Ouyang, Yan Gong, Conghua Xie   +10 more
wiley   +1 more source

Development of a High-Throughput Screening Platform and a Pathogenesis Model for <i>Leishmania</i> Infection Based on Mouse Hepatic Organoids. [PDF]

Int J Mol Sci
González-Montero MC, Andrés-Rodríguez J, Criado M, Andrés S, Galli G, Fernández-Rubio C, Pérez-Pertejo Y, Reguera RM, Balaña-Fouce R, García-Estrada C.   +9 more
europepmc   +1 more source

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

Protocol for the establishment and morphological characterization of long-term cultivated murine cerebral organoids. [PDF]

STAR Protoc
El-Debs I, Knittler MR, Mettenleiter TC, Mason JO, Sehl-Ewert J.   +4 more
europepmc   +1 more source