Results 181 to 190 of about 7,059 (201)
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Biochemistry, 1994
Organophosphates, such as parathion and paraoxon, constitute the largest class of insecticides currently used in industrialized nations. In addition, many of these compounds are known to inhibit mammalian acetylcholinesterases thereby acting as nerve agents.
M M, Benning +3 more
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Organophosphates, such as parathion and paraoxon, constitute the largest class of insecticides currently used in industrialized nations. In addition, many of these compounds are known to inhibit mammalian acetylcholinesterases thereby acting as nerve agents.
M M, Benning +3 more
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Developing a Bioscavenger Against Organophosphate Nerve Agents
2017Organophosphate poisoning can occur from exposure to agricultural pesticides or chemical weapons. This exposure inhibits acetylcholinesterase resulting in increased acetylcholine levels within the synaptic cleft causing loss of muscle control, seizures, and death.
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Phosphorus, Sulfur, and Silicon and the Related Elements, 1999
The chiral specificity of the bacterial phosphotriesterase for enantiomeric substrates has been examined. Paraoxon (diethyl p-nitrophenyl phosphate) is the best substrate for this enzyme but this protein is quite tolerant of significant alterations to this structure.
Suk-Bong Hong, Frank Raushel
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The chiral specificity of the bacterial phosphotriesterase for enantiomeric substrates has been examined. Paraoxon (diethyl p-nitrophenyl phosphate) is the best substrate for this enzyme but this protein is quite tolerant of significant alterations to this structure.
Suk-Bong Hong, Frank Raushel
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SYNTHESIS AND STRUCTURE OF SOME PHOSPHONYLATED OXIMES RELATED TO ORGANOPHOSPHATE NERVE AGENTS
Phosphorus, Sulfur, and Silicon and the Related Elements, 1991Abstract Oximes, and in particular oximate salts, can be useful nucleophiles for the treatment of organophosphate nerve agent poisoning and decontamination of chemical warfare agents. In this paper, the reactions of phosphonochloridate analogues of the chemical warfare nerve agents VX, GB, and GA and the oximes 2-butanone oxime, 2,3-butanedione ...
Camille A. Boulet, Arnold S. Hansen
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Organophosphates⧸Nerve Agent Poisoning: Mechanism of Action, Diagnosis, Prophylaxis, And Treatment
2004OP/nerve agents are still considered as important chemicals acting on living organisms and are widely used. They are characterized according to their action as compounds influencing cholinergic nerve transmission via inhibition of AChE. Modeling of this action and extrapolation of experimental data from animals to humans is more possible for highly ...
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2000
Amperometric enzyme electrodes for field, on-site and in-situ/on-line remote, monitoring of organophosphate nerve agents is reported. The sensors rely upon the coupling of the rapid biocatalytic hydrolysis of the organophosphates by the immobilized organophosphorus hydrolase and the sensitive and rapid anodic detection of p-nitrophenol product.
Ashok Mulchandani +4 more
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Amperometric enzyme electrodes for field, on-site and in-situ/on-line remote, monitoring of organophosphate nerve agents is reported. The sensors rely upon the coupling of the rapid biocatalytic hydrolysis of the organophosphates by the immobilized organophosphorus hydrolase and the sensitive and rapid anodic detection of p-nitrophenol product.
Ashok Mulchandani +4 more
openaire +1 more source
Treatment of Organophosphate Nerve Agents, Current Therapy and Future Prospectives
1999Dramatic improvements in the treatment of organophosphate poisoning have been made over the past few years. Additional exciting advances which will hopefully be fielded in the future, are currently at various stages of development in various countries.
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