Combined Pre- and Posttreatment of Paraoxon Exposure [PDF]
Molecules, 2020 Aims: Organophosphates (OPCs), useful agents as pesticides, also represent a serious health hazard. Standard therapy with atropine and established oxime-type enzyme reactivators is unsatisfactory.
Dietrich E Lorke +4 more
doaj +3 more sources
Journal of Pharmaceutical Analysis, 2021 A new electrochemical sensor for organophosphate pesticide (methyl-paraoxon) detection based on bifunctional cerium oxide (CeO2) nanozyme is here reported for the first time.
Wei Jinchao +2 more
exaly +3 more sources
Onset rate and intensity of signs of organophosphate poisoning related to paraoxon dose and survival in rats [PDF]
Scripta Medica, 2021 Introduction: Oganophosphorus compounds (OP) bind to acetylcholinesterase (AChE) and inactivate it. In the synaptic cleft, undestroyed and accumulated acetylcholine produce the acute cholinergic effects.
Maksimović Žana M. +4 more
doaj +1 more source
Dose-Dependency of Toxic Signs and Outcomes of Paraoxon Poisoning in Rats
Acta Medica, 2022 Organophosphorus compounds induce irreversible inhibition of acetylcholinesterase, which then produces clinically manifested muscarinic, nicotinic and central effects.
Žana M. Maksimović +2 more
doaj +1 more source
Cognitive and Cellular Effects of Combined Organophosphate Toxicity and Mild Traumatic Brain Injury
Biomedicines, 2023 Traumatic brain injury (TBI) is considered the most common neurological disorder among people under the age of 50. In modern combat zones, a combination of TBI and organophosphates (OP) can cause both fatal and long-term effects on the brain. We utilized
Dor Freidin +8 more
doaj +1 more source
Erythrocytes as Carriers of Therapeutic Enzymes. [PDF]
, 2020 Therapeutic enzymes are administered for the treatment of a wide variety of diseases. They exert their effects through binding with a high affinity and specificity to disease-causing substrates to catalyze their conversion to a non-noxious product, to ...
Bax, BE
core +1 more source
The lesion site of organophosphorus-induced central apnea and the effects of antidotes
Scientific Reports, 2023 Organophosphorus poisoning kills individuals by causing central apnea; however, the underlying cause of death remains unclear. Following findings that the pre-Bötzinger complex impairment alone does not account for central apnea, we analyzed the effect ...
Kazuhito Nomura +3 more
doaj +1 more source
International Journal of Electrochemical Science, 2021 Here, the NiOFe2O3@CNTs nanocomposite modified glassy carbon electrode (NiOFe2O3@CNTs/GCE) as nonenzymatic sensor was prepared for electrochemical determination of paraoxon in agricultural wastewater and apple juice.
Xiaoping Zhang +5 more
doaj +1 more source
Role of the Calcium Plateau in the Neuronal Injury and Behavioral Morbidities Following Organophosphate Intoxication [PDF]
, 2016 Organophosphate (OP) chemicals include nerve agents and pesticides, and there is a growing concern of OP based chemical attacks against civilians. Current antidotes are essential in limiting immediate mortality associated with OP exposure.
Battaglia F.P. +8 more
core +2 more sources
Evaluation of a Brain Acetylcholinesterase Extraction Method and Kinetic Constants after Methyl-Paraoxon Inhibition in Three Brazilian Fish Species. [PDF]
PLoS ONE, 2016 Acetylcholinesterase (AChE) is an important enzyme in the control of the neuronal action potential and sensitive to organophosphate inhibition. Brain fish AChE is less sensitive to organophosphate inhibition than AChE from terrestrial animals, although ...
A P Freitas +5 more
doaj +1 more source