Results 11 to 20 of about 5,226 (177)

Enhancing Paraoxon Binding to Organophosphorus Hydrolase Active Site [PDF]

International Journal of Molecular Sciences, 2021
Organophosphorus hydrolase (OPH) is a metalloenzyme that can hydrolyze organophosphorus agents resulting in products that are generally of reduced toxicity. The best OPH substrate found to date is diethyl p-nitrophenyl phosphate (paraoxon). Most structural and kinetic studies assume that the binding orientation of paraoxon is identical to that of ...
Léa El Khoury, David L. Mobley, Dongmei Ye, Susan B. Rempe   +3 more
openaire   +5 more sources

DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress. [PDF]

, 2014
Loss-of-function mutations in DJ-1 (PARK7) gene account for about 1% of all familial Parkinson's disease (PD). While its physiological function(s) are not completely clear, DJ-1 protects neurons against oxidative stress in both in vitro and in vivo ...
Aleyasin, Hossein, Bourquard, Noam, Callaghan, Steve, Figeys, Daniel, Huang, En, Irrcher, Isabella, Kim, Raymond H, Mak, Tak W, Park, David S, Parsanejad, Mohammad, Qu, Dianbo, Reddy, Srinivasa T, Rousseaux, Maxime WC, Slack, Ruth S, Vaillant, Dominique C, Zhang, Yi   +15 more
core   +2 more sources

Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs. [PDF]

, 2013
Organophosphorus pesticides (OPs) are implicated in human asthma. We previously demonstrated that, at concentrations that do not inhibit acetylcholinesterase activity, the OP parathion causes airway hyperreactivity in guinea pigs as a result of ...
Allison D. Fryer, Becky J. Proskocil, Borish L, Crain EF, Crinnion WJ, David B. Jacoby, Donald A. Bruun, Gallo MA, Grodzki AC, Lu C, Nico van Rooijen, Pamela J. Lein, Rozyk KJ   +12 more
core   +1 more source

Species Differences in Paraoxonase Mediated Hydrolysis of Several Organophosphorus Insecticide Metabolites

Journal of Toxicology, 2015
Paraoxonase (PON1) is a calcium dependent enzyme that is capable of hydrolyzing organophosphate anticholinesterases. PON1 activity is present in most mammals and previous research established that PON1 activity differs depending on the species.
Russell L. Carr, Mary Beth Dail, Howard W. Chambers, Janice E. Chambers   +3 more
doaj   +1 more source

The Organophosphate Paraoxon and Its Antidote Obidoxime Inhibit Thrombin Activity and Affect Coagulation In Vitro. [PDF]

PLoS ONE, 2016
Organophosphates (OPs) are potentially able to affect serine proteases by reacting with their active site. The potential effects of OPs on coagulation factors such as thrombin and on coagulation tests have been only partially characterized and potential ...
Valery Golderman, Efrat Shavit-Stein, Ilia Tamarin, Yossi Rosman, Shai Shrot, Nurit Rosenberg, Nicola Maggio, Joab Chapman, Arik Eisenkraft   +8 more
doaj   +1 more source

Pharmacological Blockade of the Calcium Plateau Provides Neuroprotection Following Organophosphate Paraoxon Induced Status Epilepticus in Rats [PDF]

, 2016
Organophosphate (OP) compounds which include nerve agents and pesticides are considered chemical threat agents. Currently approved antidotes are crucial in limiting OP mediated acute mortality.
Ajdacic-Gross, Bajgar, Baker, Barkus, Battaglia, Bengtson, Beverly A. Huang, Campbell, Chemical Hazards Emergency Medical Management, de Araujo Furtado, DeLorenzo, DeLorenzo, Deshpande, Deshpande, Deshpande, Deshpande, Deshpande, Faure, Filbert, Grynkiewicz, Haley, Helmstaedter, Hood, Konradsen, Kristin F. Phillips, Laxmikant S. Deshpande, Li, Li, Loubinoux, Nagarkatti, Neligan, Niebauer, Peng, Phillips, Raghupathi, Raza, Robert E. Blair, Robert J. DeLorenzo, Rod, Savage, Sellstrom, Than, Truitt, Tuovinen   +43 more
core   +2 more sources

Magnetic-nanoparticles-based fluorescent immunoassay for individual and simultaneous determination of dichlorvos and paraoxon in milk

Food and Agricultural Immunology, 2018
A sensitive and rapid magnetic-nanoparticles-based fluorescent immunoassay (MNPs-FIA) for individual and simultaneous determination of dichlorvos (DDVP) and paraoxon in untreated raw milk was developed.
Marina Yaneva, Yavor Ivanov, Nikola Todorov, Tzonka Godjevargova   +3 more
doaj   +1 more source

PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos. [PDF]

, 2012
Animal studies have shown that paraoxonase 1 (PON1) genotype can influence susceptibility to the organophosphorus pesticide chlorpyrifos (CPF). However, Monte Carlo analysis suggests that PON1 genotype may not affect CPF-related toxicity at low exposure ...
Bonner, Matthew R, Browne, Richard W, Crane, Alice L, Ellison, Corie A, Knaak, James B, Lein, Pamela J, Olson, James R   +6 more
core   +1 more source

Development and Characterization of Nano-Ink from Silicon Carbide/Multi-Walled Carbon Nanotubes/Synthesized Silver Nanoparticles for Non-Enzymatic Paraoxon Residuals Detection

Micromachines, 2023
The ongoing advancement in the synthesis of new nanomaterials has accelerated the rapid development of non-enzymatic pesticide sensors based on electrochemical platforms.
Itsarapong Chuasontia, Wichaya Sirisom, Natthapon Nakpathomkun, Surachet Toommee, Chiravoot Pechyen, Benchamaporn Tangnorawich, Yardnapar Parcharoen   +6 more
doaj   +1 more source

Cognitive Function and Hippocampal Glutathione and Malondialdehyde Levels in Paraoxon-intoxicated Rats

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Exposure to organophosphorus (OP) compounds may contribute to an increased risk of cognitive impairments and induction of oxidative stress. The present study was designed to evaluate the effects of exposure to paraoxon (the active
Sakineh Shafia, Fatemeh Yazdani Azadboni, Zohreh Zare, Moslem Mohammadi   +3 more
doaj