Results 31 to 40 of about 3,507 (204)

Chemoselective Preparation of New Families of Phenolic-Organoselenium Hybrids—A Biological Assessment

Molecules, 2022
Being aware of the enormous biological potential of organoselenium and polyphenolic compounds, we have accomplished the preparation of novel hybrids, combining both pharmacophores in order to obtain new antioxidant and antiproliferative agents.
Paloma Begines, Sergio Martos, Irene Lagunes, Inés Maya, José M. Padrón, Óscar López, José G. Fernández-Bolaños   +6 more
doaj   +1 more source

Selenium- and Tellurium-Based Antioxidants for Modulating Inflammation and Effects on Osteoblastic Activity

Antioxidants, 2017
Increased oxidative stress plays a significant role in the etiology of bone diseases. Heightened levels of H2O2 disrupt bone homeostasis, leading to greater bone resorption than bone formation. Organochalcogen compounds could act as free radical trapping
Xi Lu, Gemma Mestres, Vijay Pal Singh, Pedram Effati, Jia-Fei Poon, Lars Engman, Marjam Karlsson Ott   +6 more
doaj   +1 more source

Swimming exercise and diphenyl diselenide-supplemented diet modulate cerebral cortical and striatal GABA uptake in aged rats

Anais da Academia Brasileira de Ciências, 2022
Aging is characterized by several neurochemical modifications involving structural proteins and neurotransmitters. Exercise has been recognized as an enhancer of overall health; whereas, diphenyl diselenide (PhSe)2 has been reported to have antioxidant ...
ANA PAULA PESARICO, JOSÉ L. CECHELLA, CRISTINA W. NOGUEIRA, SUZAN G. ROSA   +3 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Novel Hydroxamic Acid-Based Organoselenium Hybrids

Pharmaceuticals, 2023
We report the design and synthesis of novel hydroxamic acid-tethered organoselenium (OSe) hybrids. Their antimicrobial and anticancer activities were assessed against different microbes (e.g., Candida albicans (C. albicans), Escherichia coli (E.
Jameelah S. Alotaibi, Yasair S. Al-Faiyz, Saad Shaaban   +2 more
doaj   +1 more source

Organoselenium Compounds in Catalysis

Synthesis, 2023
AbstractIn this article we have focused on the use of selenium in catalysis along with the proposed reaction mechanisms. With increasing interest in selenium chemistry, we have highlighted the most significant features of this subject, mainly in the last years.
Juan B. Rodríguez, Carola Gallo-Rodriguez   +1 more
openaire   +2 more sources

Crystal structure of 4-phenyl-1-{2-[(2,4,6-trimethylphenyl)selanyl]phenyl}-1H-1,2,3-triazole

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C23H21N3Se, the C-bound phenyl ring is almost coplanar with the central five-membered ring [dihedral angle = 2.84 (10)°], but the N-bound benzene ring is inclined [dihedral angle = 47.52 (10)°].
Leandro R. S. Camargo, Julio Zukerman-Schpector, Anna M. Deobald, Antonio L. Braga, Edward R. T. Tiekink   +4 more
doaj   +1 more source

Recent Advances in the Synthesis of Selenophenes and Their Derivatives

Molecules, 2020
The selenophene derivatives are an important class of selenium-based heterocyclics. These compounds play an important role in prospecting new drugs, as well as in the development of new light-emitting materials.
Paola S. Hellwig, Thiago J. Peglow, Filipe Penteado, Luana Bagnoli, Gelson Perin, Eder J. Lenardão   +5 more
doaj   +1 more source

In Silico Investigation on the Binding of Organoselenium Compounds with Target Proteins of SARS-CoV-2 Infection Cycle

, 2020
Since the outbreak of coronavirus disease 2019 (COVID-19), researchers have been investigating the potential of several low molecular weight compounds from both natural and synthetic origins to design anti-viral drugs against SARS-CoV-2. On similar lines,
Beena Gobind, Singh, Amit, Kunwar
core   +1 more source

Mn(III)-Catalyzed Synthesis of Selenophosphates and Tellurophosphates

Molecules
Selenophosphates and tellurophosphates are important classes of organophosphorus compounds that exhibit unique reactivity, tunable redox properties, and significant biological activity.
Jialu Wang, Jun Liu, Yuhui Xie, Changjiang Wu, Xinyu Wang, Gong-Qing Liu   +5 more
doaj   +1 more source

Masked Phenolic-Selenium Conjugates: Potent and Selective Antiproliferative Agents Overcoming P-gp Resistance

Pharmaceuticals, 2020
Cancer accounts for one of the most complex diseases nowadays due to its multifactorial nature. Despite the vast number of cytotoxic agents developed so far, good therapeutic approaches are not always reached.
Paloma Begines, Lucía Sevilla-Horrillo, Adrián Puerta, Rebecca Puckett, Samuel Bayort, Irene Lagunes, Inés Maya, José M. Padrón, Óscar López, José G. Fernández-Bolaños   +9 more
doaj   +1 more source