Results 11 to 20 of about 569,837 (343)
Dynamics of replication origin over-activation [PDF]
Nature Communications, 2021 DNA replication processes are often dysregulated in cancer. Here the authors analyse DNA synthesis patterns in cancer cells undergoing partial genome re-replication to reveal that re-replication exhibits aberrant replication fork dynamics and a skewed ...
Haiqing Fu +15 more
doaj +3 more sources
Architectural instability, inverted skews and mitochondrial phylogenomics of Isopoda: outgroup choice affects the long-branch attraction artefacts [PDF]
Royal Society Open Science, 2020 The majority strand of mitochondrial genomes of crustaceans usually exhibits negative GC skews. Most isopods exhibit an inversed strand asymmetry, believed to be a consequence of an inversion of the replication origin (ROI). Recently, we proposed that an
Hong Zou +7 more
doaj +1 more source
G-quadruplexes of KSHV oriLyt play important roles in promoting lytic DNA replication
Microbiology Spectrum, 2023 Kaposi’s sarcoma-associated herpesvirus (KSHV) utilizes distinct origins of DNA replication (origin of replications) during the latent and lytic phases of its life cycle.
Prerna Dabral +2 more
doaj +1 more source
Intraspecies Variation in Tetrahymena rostrata
Microorganisms, 2021 Two distinct isolates of the facultative parasite, Tetrahymena rostrata were compared, identifying and utilising markers that are useful for studying clonal variation within the species were identified and utilised. The sequences of mitochondrial genomes
Anne Watt +5 more
doaj +1 more source
Impact of the Expression System on Recombinant Protein Production in Escherichia coli BL21
Frontiers in Microbiology, 2021 Recombinant protein production for medical, academic, or industrial applications is essential for our current life. Recombinant proteins are obtained mainly through microbial fermentation, with Escherichia coli being the host most used. In spite of that,
Gema Lozano Terol +5 more
doaj +1 more source
Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes
Nucleus, 2023 In eukaryotic genomes, hundreds to thousands of potential start sites of DNA replication named origins are dispersed across each of the linear chromosomes.
Clare S.K. Lee +2 more
doaj +1 more source
Microbiology Spectrum, 2022 Adaptation through the fitness landscape may be influenced by the gene pool or expression network. However, genetic factors that determine the contribution of beneficial mutations during adaptive evolution are poorly understood.
Kitae Kim +3 more
doaj +1 more source
Improved Plasmid-Based Inducible and Constitutive Gene Expression in Corynebacterium glutamicum
Microorganisms, 2021 Corynebacterium glutamicum has been safely used in white biotechnology for the last 60 years and the portfolio of new pathways and products is increasing rapidly.
Nadja A. Henke +2 more
doaj +1 more source
mBio, 2023 Replication-initiating HUH endonucleases (Reps) are sequence-specific nucleases that cleave and rejoin single-stranded DNA (ssDNA) during rolling-circle replication.
Adam T. Smiley +7 more
doaj +1 more source
tRNA sequences can assemble into a replicator
eLife, 2021 Can replication and translation emerge in a single mechanism via self-assembly? The key molecule, transfer RNA (tRNA), is one of the most ancient molecules and contains the genetic code.
Alexandra Kühnlein +2 more
doaj +1 more source