Results 21 to 30 of about 587,545 (300)

Rif1 is a global regulator of timing of replication origin firing in fission yeast.

Genes & Development, 2012
One of the long-standing questions in eukaryotic DNA replication is the mechanisms that determine where and when a particular segment of the genome is replicated.
Motoshi Hayano, Yutaka Kanoh, S. Matsumoto, Claire Renard-Guillet, K. Shirahige, H. Masai   +5 more
semanticscholar   +1 more source

Damage-induced phosphorylation of Sld3 is important to block late origin firing. [PDF]

, 2010
Origins of replication are activated throughout the S phase of the cell cycle such that some origins fire early and others fire late to ensure that each chromosome is completely replicated in a timely fashion.
Defazio-Eli, Lisa G, Jonsson, Zophonias O, Lopez-Mosqueda, Jaime, Maas, Nancy L, Toczyski, David P, Wohlschlegel, James   +5 more
core   +2 more sources

Regulated Eukaryotic DNA Replication Origin Firing with Purified Proteins

Nature, 2015
Eukaryotic cells initiate DNA replication from multiple origins, which must be tightly regulated to promote precise genome duplication in every cell cycle.
Joseph T. P. Yeeles, T. Deegan, Agnieszka Janska, A. Early, J. Diffley   +4 more
semanticscholar   +1 more source

The dynamics of replication licensing in live Caenorhabditis elegans embryos [PDF]

, 2012
Accurate DNA replication requires proper regulation of replication licensing, which entails loading MCM-2-7 onto replication origins. In this paper, we provide the first comprehensive view of replication licensing in vivo, using video microscopy of ...
Anton Gartner, Ashley Craig, Baldinger, Blow, Blow, Brauchle, Brenner, Cheeseman, Chen, Clarey, Clarey, DePamphilis, Drury, Edgar, Encalada, Evrin, Galy, Gambus, Gillespie, Hadwiger, Harvey, Ilves, J. Julian Blow, Kamath, Kim, Kisielewska, Korzelius, Kuipers, Li, Li, Li, Liu, Matthieu Querenet, McNairn, McNally, Moyer, Oehlmann, Praitis, Prokhorova, Quinn, Randell, Remi Sonneville, Remus, Rothbauer, Rowles, Shelton, Siddiqui, Speck, Sönnichsen, Tada, Timmons, Waga, Wallenfang, Wohlschlegel, Yanagi, Yang, Zhong   +56 more
core   +4 more sources

Conservation of replication timing reveals global and local regulation of replication origin activity

Genome Research, 2012
DNA replication initiates from defined locations called replication origins; some origins are highly active, whereas others are dormant and rarely used. Origins also differ in their activation time, resulting in particular genomic regions replicating at ...
Carolin A. Müller, Conrad A. Nieduszynski   +1 more
semanticscholar   +1 more source

Early initiation of a replication origin tethered at the nuclear periphery [PDF]

, 2010
Peer reviewedPublisher ...
Ansari, Brewer, Brickner, Bystricky, Cimbora, Cosgrove, Dimitrova, Donaldson, Ebrahimi, Ferguson, Friedman, Friedman, Friedman, Friedman, Goren, Hediger, Heun, Hiraga, Huberman, Iwase, Kitamura, Knott, Laroche, Li, McCarroll, Nieduszynski, Raghuraman, Shirahige, Straight, Taddei, Vogelauer, Yamashita, Zappulla   +32 more
core   +2 more sources

Mycobacterium tuberculosis Origin of Replication and the Promoter for Immunodominant Secreted Antigen 85B Are the Targets of MtrA, the Essential Response Regulator*

Journal of Biological Chemistry, 2010
Efficient proliferation of Mycobacterium tuberculosis (Mtb) inside macrophage requires that the essential response regulator MtrA be optimally phosphorylated. However, the genomic targets of MtrA have not been identified.
M. Rajagopalan, R. Dziedzic, Maha Al Zayer, Dorota L. Stankowska, M. Ouimet, D. P. Bastedo, G. Marczynski, M. Madiraju   +7 more
semanticscholar   +1 more source

A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations. [PDF]

, 2012
BackgroundEukaryotic cell proliferation involves DNA replication, a tightly regulated process mediated by a multitude of protein factors. In budding yeast, the initiation of replication is facilitated by the heterohexameric origin recognition complex ...
DaSilva, Lance F, Duncker, Bernard P, Gidvani, Rohan D, Ingalls, Brian P, Li, Grace, McConkey, Brendan J, Sudmant, Peter   +6 more
core   +3 more sources

Speciation Through the Lens of Population Dynamics: A Theoretical Primer on How Small and Large Populations Diverge

Population Ecology, EarlyView.
Population size and dynamics fundamentally shape speciation by influencing genetic drift, founder events, and adaptive potential. Small populations may speciate rapidly due to stronger drift, whereas large populations harbor more genetic diversity, which can alter divergence trajectories. We highlight theoretical models that incorporate population size
Ryo Yamaguchi, Hidaka Kubo, Tokuya Ogawa, Hayate Omura   +3 more
wiley   +1 more source

Escalation of error catastrophe for enzymatic self-replicators [PDF]

, 2007
It is a long-standing question in origin-of-life research whether the information content of replicating molecules can be maintained in the presence of replication errors.
B. Obermayer, E. Frey, Jain K. Krug J., Schuster P., Stadler P., Tee G.   +5 more
core   +2 more sources