Results 31 to 40 of about 587,545 (300)

Isolation of the origin of replication associated with the amplified Chinese hamster dihydrofolate reductase domain.

Proceedings of the National Academy of Sciences of the United States of America, 1986
W. Burhans, J. Selegue, N. Heintz
semanticscholar   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

New stopping criteria for segmenting DNA sequences [PDF]

, 2001
We propose a solution on the stopping criterion in segmenting inhomogeneous DNA sequences with complex statistical patterns. This new stopping criterion is based on Bayesian Information Criterion (BIC) in the model selection framework. When this stopping
A. Audit, A. E. Raftery, A. W. F. Edwards, B. James, C. K. Peng, F. R. Blattner, G. Bernardi, G. K. Zipf, G. Schwartz, H. Jeffreys, J. L. Oliver, J. Lin, J. V. Braum, K. P. Burnham, M. Johnson, M. V. Olson, P. Bernaola-Galván, P. Bernaola-Galván, P. Carpena, P. L. Krapivsky, R. F. Voss, R. Román-Roldán, S. Redney, V. E. Ramensky, W. Li, W. Li, W. Li, W. Li, W. Li, W. Li, Wentian Li   +30 more
core   +2 more sources

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Kinetic model of DNA replication in eukaryotic organisms

, 2003
We formulate a kinetic model of DNA replication that quantitatively describes recent results on DNA replication in the in vitro system of Xenopus laevis prior to the mid-blastula transition.
Avrami, Avrami, Avrami, Ben-Naim, Bensimon, Berezney, Blow, Blow, Blow, Blow, Blumenthal, Brewer, Buongiorno-Nardelli, Cahn, Cairns, Christian, Coverley, Friedman, Gilbert, Gomez, Hand, Herrick, Herrick, Huberman, Hyrien, Jackson, Jasny, Johnson, Kolmogorov, Laskey, Lu, Lucas, Mahbubani, Marheineke, Michalet, Mills, Pasero, Pierron, Plischke, Press, Raghuraman, Rowles, Sekimoto, Shinomiya, Shivashankar, Simon, Walter, Wu   +47 more
core   +1 more source

Avoiding chromosome pathology when replication forks collide [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2013 Macmillan Publishers Limited.Chromosome duplication normally initiates through the assembly of replication fork complexes at defined ...
Lloyd, RG, Nieduszynski, CA, Stockum, A, Upton, AL   +3 more
core   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Horizontal transfer between loose compartments stabilizes replication of fragmented ribozymes

, 2019
The emergence of replicases that can replicate themselves is a central issue in the origin of life. Recent experiments suggest that such replicases can be realized if an RNA polymerase ribozyme is divided into fragments short enough to be replicable by ...
Kamimura, Atsushi, Kaneko, Kunihiko, Matsubara, Yoshiya J., Takeuchi, Nobuto   +3 more
core   +2 more sources

The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2. [PDF]

, 2016
The origin recognition complex (ORC) coordinates a series of events that lead to initiation of DNA strand duplication. As a nuclear double stranded DNA plasmid, the papillomavirus (PV) genome resembles a mini-chromosome in infected cells.
Androphy, Elliot J., DeSmet, Marsha, Kanginakudru, Sriramana, Rietz, Anne, Roden, Richard, Wu, Wai-Hong   +5 more
core   +3 more sources

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source