Results 41 to 50 of about 569,837 (343)

Mechanism of DNA Recognition at a Viral Replication Origin [PDF]

, 2006
Recognition of the DNA origin by the Epstein-Barr nuclear antigen 1 (EBNA1) protein is the primary event in latentphase genome replication of the Epstein-Barr virus, a model for replication initiation in eukaryotes.
de Prat Gay, Gonzalo, Frappier, Lori, Freire Espeleta, Eleonora, Oddo, Cristian   +3 more
core   +1 more source

USF binding sequences from the HS4 insulator element impose early replication timing on a vertebrate replicator [PDF]

, 2012
The nuclear genomes of vertebrates show a highly organized program of DNA replication where GC-rich isochores are replicated early in S-phase, while AT-rich isochores are late replicating.
Boggetto, N., Cadoret, J-C., Chilaka, S., Hassan-Zadeh, V., Ma, M., Prioleau, M-N., West, A. G.   +6 more
core   +9 more sources

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories [PDF]

, 2010
Replication origins are licensed by loading MCM2-7 hexamers before entry into S phase. However, only ∼10% of licensed origins are normally used in S phase, with the others remaining dormant.
Anglana, Arias, Bartek, Berezney, Blow, Blow, Blow, Bourke, Boutros, Branzei, Chung, Cseresnyes, Dijkwel, Dimitrova, Doksani, Ge, Gilbert, Gillespie, Hiratani, Ibarra, J. Julian Blow, Jackson, Kitamura, Krasinska, Kunnev, Lambert, Leonhardt, Lopes, Maya-Mendoza, Ockey, Pruitt, Sadoni, Santocanale, Santocanale, Shima, Shirahige, Sporbert, Taylor, Tercero, Thomson, Timofeev, Tuduri, Woodward, Xin Quan Ge, Zachos   +44 more
core   +4 more sources

SnapShot: Origins of DNA Replication

Cell, 2015
The fundamental unit of DNA replication, the replicon, is governed by a cis-acting replicator sequence and a trans-activating initiator factor. Despite the increased size and complexity of eukaryotic genomes, eukaryotic DNA replication continues to be guided by the fundamental principles and concepts established in the replicon model.
Creager, Rachel L., Li, Yulong, MacAlpine, David M.   +2 more
openaire   +2 more sources

Damage-induced phosphorylation of Sld3 is important to block late origin firing. [PDF]

, 2010
Origins of replication are activated throughout the S phase of the cell cycle such that some origins fire early and others fire late to ensure that each chromosome is completely replicated in a timely fashion.
Defazio-Eli, Lisa G, Jonsson, Zophonias O, Lopez-Mosqueda, Jaime, Maas, Nancy L, Toczyski, David P, Wohlschlegel, James   +5 more
core   +2 more sources

Lactococcus Ceduovirus Phages Isolated from Industrial Dairy Plants—From Physiological to Genomic Analyses

Viruses, 2020
Lactococcus Ceduovirus (formerly c2virus) bacteriophages are among the three most prevalent phage types reported in dairy environments. Phages from this group conduct a strictly lytic lifestyle and cause substantial losses during milk fermentation ...
Magdalena Chmielewska-Jeznach, Jacek K. Bardowski, Agnieszka K. Szczepankowska   +2 more
doaj   +1 more source

Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication [PDF]

, 2017
Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression.
Beckerman, Bronte, Catherine A. Vaughan, Frum, Lin, Luzhna, Olivier, Oren, Rebecca A. Frum, Shilpa Singh, Steven R. Grossman, Sumitra Deb, Swati Palit Deb, Zeman, Zuazua-Villar   +14 more
core   +2 more sources

Concurrent Replication and Methylation at Mammalian Origins of Replication [PDF]

Molecular and Cellular Biology, 1998
Observations made with Escherichia coli have suggested that a lag between replication and methylation regulates initiation of replication. To address the question of whether a similar mechanism operates in mammalian cells, we have determined the temporal relationship between initiation of replication and methylation in mammalian cells both at a ...
F D, Araujo, J D, Knox, M, Szyf, G B, Price, M, Zannis-Hadjopoulos   +4 more
openaire   +2 more sources

Synchronous Replication Initiation of Multiple Origins

PRX Life, 2023
Initiating replication synchronously at multiple origins of replication allows the bacterium Escherichia coli to divide even faster than the time it takes to replicate the entire chromosome in nutrient-rich environments. What mechanisms give rise to synchronous replication initiation remains however poorly understood.
Mareike Berger, Pieter Rein ten Wolde
openaire   +3 more sources

Chromosome I controls chromosome II replication in Vibrio cholerae.

PLoS Genetics, 2014
Control of chromosome replication involves a common set of regulators in eukaryotes, whereas bacteria with divided genomes use chromosome-specific regulators. How bacterial chromosomes might communicate for replication is not known.
Jong Hwan Baek, Dhruba K Chattoraj
doaj   +1 more source