Results 91 to 100 of about 1,024,488 (281)

Transcendence over Diversity: black women in the academy [PDF]

, 2006
Universities, like many major public institutions have embraced the notion of ‘diversity’ virtually uncritically- it is seen as a moral ‘good in itself’.
Ahmed S., Ahmed S., Back L., Bhavnani R., Blanden J., Brah A., Brah A., Carter J., Casey K., Castells M., Collins P.H., Collins P.H., Connor H., Equality Challenge Unit (ECU) &, Fraser N., Freire P., Hall S., Hall S., Higher Education Funding Council for England (HEFCE), Hooks B., Hooks B., Housee S., Law I., Lopez I.H., Metcalf H., Mirza H.S., Mirza H.S., Mirza H.S., Mirza H.S., Mirza H.S., Modood T., Mohanty C.T., Morrison T., National Audit Office (NAO), Office Cabinet, Puwar N., Razack S., Reay D., Schneider-Ross, Simmonds F., Society Fawcett, Spivak G., Williams P.J., Women &, Young R.J.C.   +44 more
core   +2 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Chromatin’s Influence on Pre-Replication Complex Assembly and Function

Biology
In all eukaryotes, the initiation of DNA replication requires a stepwise assembly of factors onto the origins of DNA replication. This is pioneered by the Origin Recognition Complex, which recruits Cdc6.
Hina Ahmad, Neha Chetlangia, Supriya G. Prasanth   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Diagnostic value of serum origin recognition complex protein 1 in the progression of HBVrelated liver fibrosis

Guangxi Yike Daxue xuebao
Objective To explore the diagnostic value and significance of human serum origin recognition complex protein 1 (ORC1) in the degree of hepatitis B (HBV)-related liver fibrosis. Methods A total of 269 patients with HBV infection admitted to the Department
LIANG Hongqian, HUANG Long, REN Aoli, SU Minghua, HU Bobin, LI Qingmei, SU Tumei, YIN Qianbing, LI Aining, JIANG Jianning   +9 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. [PDF]

, 1999
The heterodimeric CD94/NKG2A receptor, expressed by mouse natural killer (NK) cells, transduces inhibitory signals upon recognition of its ligand, Qa-1(b), a nonclassical major histocompatibility complex class Ib molecule.
Jamieson, AM, Raulet, DH, Vance, RE
core   +1 more source

BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication

Nature Communications
Mono-methylation of histone H4 lysine 20 (H4K20me1) regulates DNA replication, cell cycle progression and DNA damage repair. How exactly H4K20me1 regulates these biological processes remains unclear.
Dongxu Li, Zhi-Min Zhang, Liu Mei, Yao Yu, Yiran Guo, Samuel G. Mackintosh, Jianbin Chen, David F. Allison, Arum Kim, Aaron J. Storey, Ricky D. Edmondson, Stephanie D. Byrum, Alan J. Tackett, Ling Cai, Jeanette G. Cook, Jikui Song, Gang Greg Wang   +16 more
doaj   +1 more source