Results 71 to 80 of about 207,238 (265)

Inhibitory effects of acidic phospholipids on the binding of origin-recognition complex to origin DNA [PDF]

Biochemical Journal, 2002
Origin-recognition complex (ORC), a candidate initiator of chromosomal DNA replication in eukaryotes, shares certain biochemical characteristics with DnaA, the initiator of chromosomal DNA replication in prokaryotes. These similarities include origin-specific DNA binding, ATP binding and ATPase activity.
Jong-Ryul, Lee, Masaki, Makise, Hitomi, Takenaka, Naoko, Takahashi, Yoshihiro, Yamaguchi, Tomofusa, Tsuchiya, Tohru, Mizushima   +6 more
openaire   +2 more sources

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

CISAPS: Complex Informational Spectrum for the Analysis of Protein Sequences [PDF]

, 2015
Complex informational spectrum analysis for protein sequences (CISAPS) and its web-based server are developed and presented. As recent studies show, only the use of the absolute spectrum in the analysis of protein sequences using the informational ...
Chrysostomou, Charalambos, H. Seker (7665395), N. Aydin (7665398), Seker, Huseyin, Aydin, Nizamettin, Charalambos Chrysostomou (5236139)   +5 more
core   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Initiation of DNA replication from non-canonical sites on an origin-depleted chromosome. [PDF]

PLoS ONE, 2014
Eukaryotic DNA replication initiates from multiple sites on each chromosome called replication origins (origins). In the budding yeast Saccharomyces cerevisiae, origins are defined at discrete sites.
Naomi L Bogenschutz, Jairo Rodriguez, Toshio Tsukiyama   +2 more
doaj   +1 more source

Degradation of origin recognition complex large subunit by the anaphase-promoting complex in Drosophila [PDF]

The EMBO Journal, 2003
The initiation of DNA synthesis is thought to occur at sites bound by a heteromeric origin recognition complex (ORC). Previously, we have shown that in Drosophila, the level of the large subunit, ORC1, is modulated during cell cycle progression and that changes in ORC1 concentration alter origin utilization during development.
Marito, Araki, Robin P, Wharton, Zhanyun, Tang, Hongtao, Yu, Maki, Asano   +4 more
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The dynamics of genome replication using deep sequencing [PDF]

, 2014
Peer ...
Blythe, Martin J., Nieduszynski, Conrad A, de Moura, Alessandro P. S., Nakato, Ryuichiro, Shirahige, Katsuhiko, de Moura, Alessandro P S, Malla, Sunir, Nieduszynski, Conrad A., Hawkins, Michelle, Müller, Carolin A, M�ller, Carolin A., Müller, Carolin A., de Moura, Alessandro P.S., Retkute, Renata, Wilson, Ray, Komata, Makiko, Blythe, Martin J   +16 more
core   +1 more source

Kinetics of ATP Binding to the Origin Recognition Complex of Saccharomyces cerevisiae [PDF]

Journal of Biological Chemistry, 2003
Origin recognition complex (ORC), a candidate initiator of chromosomal DNA replication in eukaryotes, binds specifically to ATP through two of its subunits (Orc1p and Orc5p). In this study, we investigated the kinetics of ATP binding to ORC by a filter binding assay.
Masaki, Makise, Hitomi, Takenaka, Wakako, Kuwae, Naoko, Takahashi, Tomofusa, Tsuchiya, Tohru, Mizushima   +5 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source