Results 51 to 60 of about 207,238 (265)
eLife, 2015 Heterochromatic domains are enriched with repressive histone marks, including histone H3 lysine 9 methylation, written by lysine methyltransferases (KMTs).
Sumanprava Giri +10 more
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Architecture of the Yeast Origin Recognition Complex Bound to Origins of DNA Replication [PDF]
Molecular and Cellular Biology, 1997 In many organisms, the replication of DNA requires the binding of a protein called the initiator to DNA sites referred to as origins of replication. Analyses of multiple initiator proteins bound to their cognate origins have provided important insights into the mechanism by which DNA replication is initiated.
D G, Lee, S P, Bell
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eLife, 2017 Human cells that lack a subunit in their origin recognition complex are viable, which suggests the existence of alternative mechanisms to initiate DNA replication.
Stephen P Bell
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DNA replication origins retain mobile licensing proteins
Nature Communications, 2021 Eukaryotic DNA replication is regulated to ensure copying of the genome (only) once per cell cycle. Here the authors, using optical trapping and confocal microscopy, demonstrate the dynamics of the origin recognition complex and subsequent intermediates ...
Humberto Sánchez +7 more
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Target Recognition of SAR Image Based on CN-GAN and CNN in Complex Environment
IEEE Access, 2021 In recent years, with the rapid development of deep learning, the research of radar image automatic target recognition (ATR) has made great progress. However, because of the complex environments and special imaging principles, Synthetic Aperture Radar ...
Cong Mao +4 more
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The origin recognition complex is dispensable for endoreplication in Drosophila [PDF]
Proceedings of the National Academy of Sciences, 2008 The origin recognition complex (ORC) is an essential component of the prereplication complex (pre-RC) in mitotic cell cycles. The role of ORC as a foundation to assemble the pre-RC is conserved from yeast to human. Furthermore, in metazoans ORC plays a key role in determining the timing of replication initiation and origin usage ...
So Young, Park, Maki, Asano
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Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation. [PDF]
Nucleic Acids Res, 2016 Initiation of DNA replication depends upon recognition of genomic sites, termed origins, by AAA+ ATPases. In prokaryotes a single factor binds each origin, whereas in eukaryotes this role is played by a six-protein origin recognition complex (ORC).
Marques CA +7 more
europepmc +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker +11 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa +8 more
wiley +1 more source
BMC Biology, 2007 Background Histone modifications have been implicated in the regulation of transcription and, more recently, in DNA replication and repair. In yeast, a major conserved histone acetyltransferase, Hat1p, preferentially acetylates lysine residues 5 and 12 ...
Greenblatt Jack F +7 more
doaj +1 more source