Results 51 to 60 of about 7,923,921 (265)
Nucleosome-directed replication origin licensing independent of a consensus DNA sequence
Nature Communications, 2022 Most eukaryotes do not use a consensus DNA sequence as binding sites for the origin recognition complex (ORC) to initiate DNA replication, however budding yeast do. Here the authors show S. cerevisiae ORC can bind nucleosomes near nucleosome-free regions
Sai Li +5 more
doaj +1 more source
International Journal of General Medicine, 2021 Shaohua Chen,1,2 Ziyao Jin,3 Linfeng Xin,4 Lv Lv,2 Xuemei Zhang,3 Yizhen Gong,5 Jianlun Liu1 1Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nangning, People’s Republic of China; 2Department of Breast and Thyroid Surgery ...
Chen S +6 more
doaj
The dynamics of replication licensing in live Caenorhabditis elegans embryos [PDF]
, 2012 Accurate DNA replication requires proper regulation of replication licensing, which entails loading MCM-2-7 onto replication origins. In this paper, we provide the first comprehensive view of replication licensing in vivo, using video microscopy of ...
Blow, J. Julian; id_orcid +10 more
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Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure. [PDF]
PLoS Genetics, 2010 Eukaryotic DNA replication origins differ both in their efficiency and in the characteristic time during S phase when they become active. The biological basis for these differences remains unknown, but they could be a consequence of chromatin structure ...
Nicolas M Berbenetz +2 more
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The role of adenosine triphosphate in the function of human origin recognition complex 4 protein [PDF]
Journal of the Serbian Chemical Society, 2010 Human origin recognition complex 4 (ORC4) protein, a subunit of the origin recognition complex, belongs to the AAA+ superfamily of adenosine triphosphate (ATP) ases.
ALEKSANDRA DIVAC +2 more
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Abnormally proximal aortic origin of the brachiocephalic artery: Surgical implications
Annals of Pediatric Cardiology, 2022 Abnormal proximal aortic origin of the brachiocephalic artery is a very rare condition. It can occur in isolation or associated with complex congenital heart disease affecting the right ventricular outflow tract. Its recognition carries relevant surgical
Sudesh Prabhu +5 more
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Architecture of the Yeast Origin Recognition Complex Bound to Origins of DNA Replication [PDF]
Molecular and Cellular Biology, 1997 In many organisms, the replication of DNA requires the binding of a protein called the initiator to DNA sites referred to as origins of replication. Analyses of multiple initiator proteins bound to their cognate origins have provided important insights into the mechanism by which DNA replication is initiated.
D G, Lee, S P, Bell
openaire +2 more sources
eLife, 2015 Heterochromatic domains are enriched with repressive histone marks, including histone H3 lysine 9 methylation, written by lysine methyltransferases (KMTs).
Sumanprava Giri +10 more
doaj +1 more source
eLife, 2017 Human cells that lack a subunit in their origin recognition complex are viable, which suggests the existence of alternative mechanisms to initiate DNA replication.
Stephen P Bell
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DNA replication origins retain mobile licensing proteins
Nature Communications, 2021 Eukaryotic DNA replication is regulated to ensure copying of the genome (only) once per cell cycle. Here the authors, using optical trapping and confocal microscopy, demonstrate the dynamics of the origin recognition complex and subsequent intermediates ...
Humberto Sánchez +7 more
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