Results 41 to 50 of about 203,895 (232)
Architecture of the Yeast Origin Recognition Complex Bound to Origins of DNA Replication [PDF]
Molecular and Cellular Biology, 1997 In many organisms, the replication of DNA requires the binding of a protein called the initiator to DNA sites referred to as origins of replication. Analyses of multiple initiator proteins bound to their cognate origins have provided important insights into the mechanism by which DNA replication is initiated.
D G, Lee, S P, Bell
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eLife, 2015 Heterochromatic domains are enriched with repressive histone marks, including histone H3 lysine 9 methylation, written by lysine methyltransferases (KMTs).
Sumanprava Giri +10 more
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The origin recognition complex is dispensable for endoreplication in Drosophila [PDF]
Proceedings of the National Academy of Sciences, 2008 The origin recognition complex (ORC) is an essential component of the prereplication complex (pre-RC) in mitotic cell cycles. The role of ORC as a foundation to assemble the pre-RC is conserved from yeast to human. Furthermore, in metazoans ORC plays a key role in determining the timing of replication initiation and origin usage ...
So Young, Park, Maki, Asano
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eLife, 2017 Human cells that lack a subunit in their origin recognition complex are viable, which suggests the existence of alternative mechanisms to initiate DNA replication.
Stephen P Bell
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DNA replication origins retain mobile licensing proteins
Nature Communications, 2021 Eukaryotic DNA replication is regulated to ensure copying of the genome (only) once per cell cycle. Here the authors, using optical trapping and confocal microscopy, demonstrate the dynamics of the origin recognition complex and subsequent intermediates ...
Humberto Sánchez +7 more
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Target Recognition of SAR Image Based on CN-GAN and CNN in Complex Environment
IEEE Access, 2021 In recent years, with the rapid development of deep learning, the research of radar image automatic target recognition (ATR) has made great progress. However, because of the complex environments and special imaging principles, Synthetic Aperture Radar ...
Cong Mao +4 more
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ATP-dependent Assembly of the Human Origin Recognition Complex [PDF]
Journal of Biological Chemistry, 2007 The origin recognition complex (ORC) was initially discovered in budding yeast extracts as a protein complex that binds with high affinity to autonomously replicating sequences in an ATP-dependent manner. We have cloned and expressed the human homologs of the ORC subunits as recombinant proteins. In contrast to other eukaryotic initiators examined thus
Khalid, Siddiqui, Bruce, Stillman
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks +5 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian +13 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier +10 more
wiley +1 more source