Results 21 to 30 of about 1,409,521 (314)

Origin Recognition Complex Subunit 4 [PDF]

Definitions, 2020
National Cancer Institute
semanticscholar   +3 more sources

Phosphorylation of ORC2 protein dissociates origin recognition complex from chromatin and replication origins. [PDF]

J Biol Chem, 2012
Background: Origin recognition complex (ORC) binds to the replication origin for initiation of eukaryotic chromosome replication. Results: Phosphorylation of human ORC2 in the S phase dissociates ORC from chromatin and replication origins.
Lee KY, Bang SW, Yoon SW, Lee SH, Yoon JB, Hwang DS.   +5 more
europepmc   +5 more sources

Origin recognition complex subunit 6 (ORC6) is a key mediator of LPS-induced NFκB activation and the pro-inflammatory response [PDF]

Cell Communication and Signaling
Lipopolysaccharide (LPS)-activated pro-inflammatory responses play a critical role in sepsis, a life-threatening condition. This study investigates the role of origin recognition complex subunit 6 (ORC6) in LPS responses in macrophages and monocytes ...
Zichen Xie, Haisu Lu, Jiayi Zheng, Jianfeng Song, Keyu Sun   +4 more
doaj   +4 more sources

Depletion of the Origin Recognition Complex Subunits Delays Aging in Budding Yeast [PDF]

Cells, 2022
Precise DNA replication is pivotal for ensuring the accurate inheritance of genetic information. To avoid genetic instability, each DNA fragment needs to be amplified only once per cell cycle.
Karolina Stępień, Adrianna Skoneczna, Monika Kula-Maximenko, Łukasz Jurczyk, Mateusz Mołoń   +4 more
doaj   +2 more sources

Structural insight into the assembly and conformational activation of human origin recognition complex. [PDF]

Cell Discov, 2020
The function of the origin recognition complex (ORC) in DNA replication is highly conserved in recognizing and marking the initiation sites. The detailed molecular mechanisms by which human ORC is reconfigured into a state competent for origin ...
Cheng J, Li N, Wang X, Hu J, Zhai Y, Gao N.   +5 more
europepmc   +2 more sources

Novel candidate biomarkers of origin recognition complex 1, 5 and 6 for survival surveillance in patients with hepatocellular carcinoma. [PDF]

J Cancer, 2020
Background: Hepatocellular carcinoma (HCC) has high morbidity and mortality and lacks effective biomarkers for early diagnosis and survival surveillance.
Wang XK, Wang QQ, Huang JL, Zhang LB, Zhou X, Liu JQ, Chen ZJ, Liao XW, Huang R, Yang CK, Zhu GZ, Han CY, Ye XP, Peng T.   +13 more
europepmc   +2 more sources

Rethinking origin licensing [PDF]

eLife, 2017
Human cells that lack a subunit in their origin recognition complex are viable, which suggests the existence of alternative mechanisms to initiate DNA replication.
Stephen P Bell
doaj   +3 more sources

Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro [PDF]

, 2000
An interaction between the origin recognition complex (ORC) and Cdc6p is the first and a key step in the initiation of chromosomal DNA replication.
Mizushima, T., Takahashi, N., Stillman, B.   +2 more
core   +3 more sources

Conformational control and DNA-binding mechanism of the metazoan origin recognition complex. [PDF]

Proc Natl Acad Sci U S A, 2018
Significance The onset of chromosomal DNA replication relies on dedicated initiator proteins to chaperone ring-shaped helicases onto DNA. In most eukaryotes, initiators are multisubunit protein complexes that require ATP to bind DNA and to aid helicase ...
Bleichert F, Leitner A, Aebersold R, Botchan MR, Berger JM.   +4 more
europepmc   +2 more sources

Influence of Origin Recognition Complex Proteins on the Copy Numbers of Three Chromosomes in Haloferax volcanii. [PDF]

J Bacteriol, 2018
The core origins of archaea are comprised of a repeat region and an adjacent gene for an origin recognition complex (ORC) protein, which is homologous to eukaryotic ORC proteins.
Ludt K, Soppa J.
europepmc   +2 more sources