Results 21 to 30 of about 203,895 (232)
Origin recognition complex subunit 6 (ORC6) is a key mediator of LPS-induced NFκB activation and the pro-inflammatory response [PDF]
Cell Communication and SignalingLipopolysaccharide (LPS)-activated pro-inflammatory responses play a critical role in sepsis, a life-threatening condition. This study investigates the role of origin recognition complex subunit 6 (ORC6) in LPS responses in macrophages and monocytes ...
Zichen Xie +4 more
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Origin Recognition Complex (ORC) Evolution Is Influenced by Global Gene Duplication/Loss Patterns in Eukaryotic Genomes. [PDF]
Genome Biol Evol, 2020 Ocaña-Pallarès E +8 more
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Crystal structure of the eukaryotic origin recognition complex. [PDF]
Nature, 2015 Initiation of cellular DNA replication is tightly controlled to sustain genomic integrity. In eukaryotes, the heterohexameric origin recognition complex (ORC) is essential for coordinating replication onset. Here we describe the crystal structure of Drosophila ORC at 3.5 Å resolution, showing that the 270 kilodalton initiator core complex comprises a ...
Bleichert F, Botchan MR, Berger JM.
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Conformational control and DNA-binding mechanism of the metazoan origin recognition complex. [PDF]
Proc Natl Acad Sci U S A, 2018 Bleichert F +4 more
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Architecture of the Human Origin Recognition Complex [PDF]
Journal of Biological Chemistry, 2001 All the human homologs of the six subunits of Saccharomyces cerevisiae origin recognition complex have been reported so far. However, not much has been reported on the nature and the characteristics of the human origin recognition complex. In an attempt to purify recombinant human ORC from insect cells infected with baculoviruses expressing HsORC ...
S K, Dhar, L, Delmolino, A, Dutta
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Assembly of the Human Origin Recognition Complex [PDF]
Journal of Biological Chemistry, 2001 The six-subunit origin recognition complex (ORC) was originally identified in the yeast Saccharomyces cerevisiae. Yeast ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors, such as Cdc6 and the Mcm proteins.
S, Vashee +3 more
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The origin recognition complex protein family. [PDF]
Genome Biol, 2009 Origin recognition complex (ORC) proteins were first discovered as a six-subunit assemblage in budding yeast that promotes the initiation of DNA replication. Orc1-5 appear to be present in all eukaryotes, and include both AAA+ and winged-helix motifs.
Duncker BP, Chesnokov IN, McConkey BJ.
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The origin recognition complex: a biochemical and structural view. [PDF]
Subcell Biochem, 2012 The origin recognition complex (ORC) was first discovered in the baker's yeast in 1992. Identification of ORC opened up a path for subsequent molecular level investigations on how eukaryotic cells initiate and control genome duplication each cell cycle.
Li H, Stillman B.
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Origin recognition complex binding to a metazoan replication origin [PDF]
Current Biology, 2001 The initiation of DNA replication in eukaryotic cells at the onset of S phase requires the origin recognition complex (ORC) [1]. This six-subunit complex, first isolated in Saccharomyces cerevisiae [2], is evolutionarily conserved [1]. ORC participates in the formation of the prereplicative complex [3], which is necessary to establish replication ...
Bielinsky, Anja-Katrin +6 more
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Nature Communications, 2023 Chromatin replication involves the assembly and activity of the replisome within the nucleosomal landscape. At the core of the replisome is the Mcm2-7 complex (MCM), which is loaded onto DNA after binding to the Origin Recognition Complex (ORC). In yeast,
Humberto Sánchez +5 more
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