Results 21 to 30 of about 7,923,921 (265)

The metazoan origin recognition complex [PDF]

Frontiers in Bioscience - Landmark, 1999
Regulated initiation of DNA replication relies on the firing of initiator proteins that bind specifically to origin DNA. The discovery of the first eukaryotic initiator, the Saccharomyces cerevisiae Origin Recognition Complex (ORC) has allowed us to discern some aspects of how the onset of replication is regulated.
Anindya Dutta, David G Quintana
exaly   +3 more sources

Origin recognition complex 6 overexpression promotes growth of glioma cells [PDF]

Cell Death and Disease
The discovery of novel oncotargets for glioma is of immense significance. We here explored the expression patterns, biological functions, and underlying mechanisms associated with ORC6 (origin recognition complex 6) in glioma.
Wen-lei Yang, Wei-feng Zhang, Yin Wang, Yue Lou, Yu Cai, Jun Zhu   +5 more
doaj   +2 more sources

Origin recognition complex binding to a metazoan replication origin [PDF]

Current Biology, 2001
The initiation of DNA replication in eukaryotic cells at the onset of S phase requires the origin recognition complex (ORC) [1]. This six-subunit complex, first isolated in Saccharomyces cerevisiae [2], is evolutionarily conserved [1]. ORC participates in the formation of the prereplicative complex [3], which is necessary to establish replication ...
Bielinsky, Anja-Katrin, Blitzblau, Hannah, Beall, Eileen L., Ezrokhi, Michael, Smith, Heidi S., Botchan, Michael R., Gerbi, Susan A.   +6 more
openaire   +4 more sources

Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6 [PDF]

Nature Communications, 2020
The origin recognition complex (ORC) is essential for loading the Mcm2–7 replicative helicase onto DNA during DNA replication initiation. Here, the authors describe several cryo-electron microscopy structures of Drosophila ORC bound to DNA and its ...
Jan Marten Schmidt, Franziska Bleichert
doaj   +2 more sources

Multi-omics analysis reveals the involvement of origin recognition complex subunit 6 in tumor immune regulation and malignant progression [PDF]

Frontiers in Immunology, 2023
BackgroundOrigin recognition complex 6 (ORC6) is one of the six highly conserved subunit proteins required for DNA replication and is essential for maintaining genome stability during cell division.
Jinfeng Zhu, Jinfeng Zhu, Qitong Chen, Qitong Chen, Liyun Zeng, Liyun Zeng, Hongyu Gao, Hongyu Gao, Tong Wu, Tong Wu, Yeqing He, Yeqing He, Jiachi Xu, Jiachi Xu, Jian Pang, Jian Pang, Jing Peng, Jing Peng, Yueqiong Deng, Yueqiong Deng, Yi Han, Yi Han, Wenjun Yi, Wenjun Yi   +23 more
doaj   +2 more sources

Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex [PDF]

Nature Communications
In eukaryotes, the origin recognition complex (ORC) faciliates the assembly of pre-replicative complex (pre-RC) at origin DNA for replication licensing.
Yue Wu, Qiongdan Zhang, Yuhan Lin, Wai Hei Lam, Yuanliang Zhai   +4 more
doaj   +2 more sources

Identification of ORC1/CDC6-interacting factors in Trypanosoma brucei reveals critical features of origin recognition complex architecture. [PDF]

PLoS ONE, 2012
DNA replication initiates by formation of a pre-replication complex on sequences termed origins. In eukaryotes, the pre-replication complex is composed of the Origin Recognition Complex (ORC), Cdc6 and the MCM replicative helicase in conjunction with ...
Calvin Tiengwe, Lucio Marcello, Helen Farr, Catarina Gadelha, Richard Burchmore, J David Barry, Stephen D Bell, Richard McCulloch   +7 more
doaj   +2 more sources

Origin recognition complex subunit 1 functions as an oncogenic driver and therapeutic target in cancer [PDF]

Discover Oncology
ORC1 is a core protein governing DNA replication initiation and cell cycle regulation, exhibiting significant overexpression in multiple malignancies where it correlates with advanced disease stage and poor prognosis.
Yixuan Ding, Shiwei Cai, Jinzhou Cai, Zhanpeng Wang, Zigui Zhu   +4 more
doaj   +2 more sources

Crystal structure of the eukaryotic origin recognition complex. [PDF]

Nature, 2015
Initiation of cellular DNA replication is tightly controlled to sustain genomic integrity. In eukaryotes, the heterohexameric origin recognition complex (ORC) is essential for coordinating replication onset. Here we describe the crystal structure of Drosophila ORC at 3.5 Å resolution, showing that the 270 kilodalton initiator core complex comprises a ...
Bleichert F, Botchan MR, Berger JM.
europepmc   +4 more sources

Systemic analysis of the DNA replication regulator origin recognition complex in lung adenocarcinomas identifies prognostic and expression significance [PDF]

Cancer Medicine, 2023
Background DNA replication alteration is a hallmark of patients with lung adenocarcinoma (LUAD) and is frequently observed in LUAD progression. Origin recognition complex (ORC) 1, ORC2, ORC3, ORC4, ORC5, and ORC6 form a replication–initiator complex to ...
Min Tang, Juan Chen, Tian Zeng, Dong‐mei Ye, Yu‐kun Li, Juan Zou, Yu‐ping Zhang   +6 more
doaj   +2 more sources