Systemic analysis of the DNA replication regulator origin recognition complex in lung adenocarcinomas identifies prognostic and expression significance [PDF]
Cancer Medicine, 2023 Background DNA replication alteration is a hallmark of patients with lung adenocarcinoma (LUAD) and is frequently observed in LUAD progression. Origin recognition complex (ORC) 1, ORC2, ORC3, ORC4, ORC5, and ORC6 form a replication–initiator complex to ...
Min Tang +6 more
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The origin recognition complex: a biochemical and structural view. [PDF]
Subcell Biochem, 2012 The origin recognition complex (ORC) was first discovered in the baker's yeast in 1992. Identification of ORC opened up a path for subsequent molecular level investigations on how eukaryotic cells initiate and control genome duplication each cell cycle ...
Li H, Stillman B.
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Origin recognition complex subunit 1 functions as an oncogenic driver and therapeutic target in cancer [PDF]
Discover OncologyORC1 is a core protein governing DNA replication initiation and cell cycle regulation, exhibiting significant overexpression in multiple malignancies where it correlates with advanced disease stage and poor prognosis.
Yixuan Ding +4 more
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Elevated origin recognition complex subunit 6 expression promotes non-small cell lung cancer cell growth [PDF]
Cell Death and DiseaseExploring novel targets for non-small cell lung cancer (NSCLC) remains of utmost importance. This study focused on ORC6 (origin recognition complex subunit 6), investigating its expression and functional significance within NSCLC.
Yong-hua Sang +6 more
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ATP dependent assembly of the human origin recognition complex [PDF]
Journal of Biological Chemistry, 2007 The Origin Recognition Complex (ORC) was initially discovered in budding yeast extracts as a protein complex that binds with high affinity to Autonomously Replicating Sequences (ARS) in an ATP dependent manner.
Stillman, B., Siddiqui, K.
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An Orc1 initiator-specific motif (ISM)-related region limits ORC–ssDNA binding and promotes replication origin specificity in budding yeast [PDF]
Frontiers in MicrobiologySingle-stranded DNA (ssDNA) is an essential intermediate of genome duplication but can also arise in the genome, including at highly transcribed loci. Although the origin recognition complex (ORC), a eukaryotic replication initiator, has been reported to
Hironori Kawakami +8 more
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The role of adenosine triphosphate in the function of human origin recognition complex 4 protein [PDF]
Journal of the Serbian Chemical Society, 2010 Human origin recognition complex 4 (ORC4) protein, a subunit of the origin recognition complex, belongs to the AAA+ superfamily of adenosine triphosphate (ATP) ases.
ALEKSANDRA DIVAC +2 more
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Origin recognition complex subunit 6 (ORC6) is a key mediator of LPS-induced NFκB activation and the pro-inflammatory response [PDF]
Cell Communication and SignalingLipopolysaccharide (LPS)-activated pro-inflammatory responses play a critical role in sepsis, a life-threatening condition. This study investigates the role of origin recognition complex subunit 6 (ORC6) in LPS responses in macrophages and monocytes ...
Zichen Xie +4 more
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A Drosophila homolog of the yeast origin recognition complex
Science, 1995 Genes from Drosophila melanogaster have been identified that encode proteins homologous to Orc2p and Orc5p of the Saccharomyces cerevisiae origin recognition complex (ORC). The abundance of the Drosophila Orc2p homolog DmORC2 is developmentally regulated
Hansen, S.K. +4 more
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Separation of origin recognition complex functions by cross-species complementation
Science, 1995 Transcriptional silencing at the HMRa locus of Saccharomyces cerevisiae requires the function of the origin recognition complex (ORC), the replication initiator of yeast.
Ehrenhofer-Murray, A.E. +4 more
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