Structure of the active form of human origin recognition complex and its ATPase motor module [PDF]
eLife, 2017 Binding of the Origin Recognition Complex (ORC) to origins of replication marks the first step in the initiation of replication of the genome in all eukaryotic cells.
Ante Tocilj +7 more
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Nonreplicative functions of the origin recognition complex. [PDF]
Nucleus, 2018 Origin recognition complex (ORC), a heteromeric six-subunit complex, is the central component of the eukaryotic pre-replication complex. Recent data from yeast, frogs, flies and mammals present compelling evidence that ORC and its individual subunits have nonreplicative functions as well.
Popova VV +3 more
europepmc +5 more sources
A dual role for the chromatin reader ORCA/LRWD1 in targeting the origin recognition complex to chromatin. [PDF]
EMBO J, 2023 Eukaryotic cells use chromatin marks to regulate the initiation of DNA replication. The origin recognition complex (ORC)-associated protein ORCA plays a critical role in heterochromatin replication in mammalian cells by recruiting the initiator ORC, but ...
Sahu S +3 more
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Origin recognition complex harbors an intrinsic nucleosome remodeling activity. [PDF]
Proc Natl Acad Sci U S A, 2022 Eukaryotic DNA replication is initiated at multiple chromosomal sites known as origins of replication that are specifically recognized by the origin recognition complex (ORC) containing multiple ATPase sites. In budding yeast, ORC binds to specific DNA sequences known as autonomously replicating sequences (ARSs) that are mostly nucleosome ...
Li S +5 more
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Architecture of the human origin recognition complex [PDF]
Journal of Biological Chemistry, 2001 All the human homologs of the six subunits of Saccharomyces cerevisiae origin recognition complex have been reported so far. However, not much has been reported on the nature and the characteristics of the human origin recognition complex.
Delmolino, Laurie +2 more
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Origin recognition complex binding to a metazoan replication origin [PDF]
Current Biology, 2001 The initiation of DNA replication in eukaryotic cells at the onset of S phase requires the origin recognition complex (ORC) [1]. This six-subunit complex, first isolated in Saccharomyces cerevisiae[2], is evolutionarily conserved [1]. ORC participates in
Botchan, Michael R. +6 more
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RNA-dependent recruitment of the origin recognition complex. [PDF]
The EMBO Journal, 2008 The origin recognition complex (ORC) has an important function in determining the initiation sites of DNA replication. In higher eukaryotes, ORC lacks sequence-specific DNA binding, and the mechanisms of ORC recruitment and origin determination are ...
Sridharan, V. +5 more
core +3 more sources
Influence of Origin Recognition Complex Proteins on the Copy Numbers of Three Chromosomes in Haloferax volcanii. [PDF]
J Bacteriol, 2018 The core origins of archaea are comprised of a repeat region and an adjacent gene for an origin recognition complex (ORC) protein, which is homologous to eukaryotic ORC proteins.
Ludt K, Soppa J.
europepmc +3 more sources
Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex [PDF]
Nature CommunicationsIn eukaryotes, the origin recognition complex (ORC) faciliates the assembly of pre-replicative complex (pre-RC) at origin DNA for replication licensing.
Yue Wu +4 more
doaj +2 more sources
Identification of ORC1/CDC6-interacting factors in Trypanosoma brucei reveals critical features of origin recognition complex architecture. [PDF]
PLoS ONE, 2012 DNA replication initiates by formation of a pre-replication complex on sequences termed origins. In eukaryotes, the pre-replication complex is composed of the Origin Recognition Complex (ORC), Cdc6 and the MCM replicative helicase in conjunction with ...
Calvin Tiengwe +7 more
doaj +2 more sources