Nonreplicative functions of the origin recognition complex. [PDF]
Nucleus, 2018 Origin recognition complex (ORC), a heteromeric six-subunit complex, is the central component of the eukaryotic pre-replication complex. Recent data from yeast, frogs, flies and mammals present compelling evidence that ORC and its individual subunits ...
Popova VV +3 more
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Crystal structure of the eukaryotic origin recognition complex. [PDF]
Nature, 2015 Initiation of cellular DNA replication is tightly controlled to sustain genomic integrity. In eukaryotes, the heterohexameric origin recognition complex (ORC) is essential for coordinating replication onset.
Bleichert F, Botchan MR, Berger JM.
europepmc +7 more sources
Origin recognition complex harbors an intrinsic nucleosome remodeling activity. [PDF]
Proc Natl Acad Sci U S A, 2022 Significance Nucleosomes package the entire eukaryotic genome, yet enzymes need access to the DNA for numerous metabolic activities, such as replication and transcription.
Li S +5 more
europepmc +4 more sources
The Origin Recognition Complex: From Origin Selection to Replication Licensing in Yeast and Humans [PDF]
Biology, 2023 Understanding human DNA replication through the study of yeast has been an extremely fruitful journey. The minichromosome maintenance (MCM) 2–7 genes that encode the catalytic core of the eukaryotic replisome were initially identified through forward ...
Bik-Kwoon Tye, Yuanliang Zhai
doaj +5 more sources
Origin recognition complex 6 overexpression promotes growth of glioma cells [PDF]
Cell Death and DiseaseThe discovery of novel oncotargets for glioma is of immense significance. We here explored the expression patterns, biological functions, and underlying mechanisms associated with ORC6 (origin recognition complex 6) in glioma.
Wen-lei Yang +5 more
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The origin recognition complex in human diseases. [PDF]
Biosci Rep, 2013 ORC (origin recognition complex) serves as the initiator for the assembly of the pre-RC (pre-replication complex) and the subsequent DNA replication.
Shen Z.
europepmc +5 more sources
Reinventing heterochromatin in budding yeasts: Sir2 and the origin recognition complex take center stage. [PDF]
Eukaryot Cell, 2011 The transcriptional silencing of the cryptic mating-type loci in Saccharomyces cerevisiae is one of the best-studied models of repressive heterochromatin.
Hickman MA, Froyd CA, Rusche LN.
europepmc +3 more sources
Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex [PDF]
Nature CommunicationsIn eukaryotes, the origin recognition complex (ORC) faciliates the assembly of pre-replicative complex (pre-RC) at origin DNA for replication licensing.
Yue Wu +4 more
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Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2010 The origin recognition complex (ORC) is a DNA replication initiator protein also known to be involved in diverse cellular functions including gene silencing, sister chromatid cohesion, telomere biology, heterochromatin localization, centromere and ...
Prasanth, S. G. +3 more
core +4 more sources
Origin Recognition Complex Subunit 3 [PDF]
Definitions, 2020 National Cancer Institute
semanticscholar +3 more sources