Nonreplicative functions of the origin recognition complex. [PDF]
Nucleus, 2018 Origin recognition complex (ORC), a heteromeric six-subunit complex, is the central component of the eukaryotic pre-replication complex. Recent data from yeast, frogs, flies and mammals present compelling evidence that ORC and its individual subunits have nonreplicative functions as well.
Popova VV +3 more
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Origin recognition complex harbors an intrinsic nucleosome remodeling activity. [PDF]
Proc Natl Acad Sci U S A, 2022 Eukaryotic DNA replication is initiated at multiple chromosomal sites known as origins of replication that are specifically recognized by the origin recognition complex (ORC) containing multiple ATPase sites. In budding yeast, ORC binds to specific DNA sequences known as autonomously replicating sequences (ARSs) that are mostly ...
Li S +5 more
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Multi-omics analysis reveals the involvement of origin recognition complex subunit 6 in tumor immune regulation and malignant progression [PDF]
Frontiers in Immunology, 2023 BackgroundOrigin recognition complex 6 (ORC6) is one of the six highly conserved subunit proteins required for DNA replication and is essential for maintaining genome stability during cell division.
Jinfeng Zhu +23 more
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Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex [PDF]
Nature CommunicationsIn eukaryotes, the origin recognition complex (ORC) faciliates the assembly of pre-replicative complex (pre-RC) at origin DNA for replication licensing.
Yue Wu +4 more
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Origin recognition complex subunit 1 functions as an oncogenic driver and therapeutic target in cancer [PDF]
Discover OncologyORC1 is a core protein governing DNA replication initiation and cell cycle regulation, exhibiting significant overexpression in multiple malignancies where it correlates with advanced disease stage and poor prognosis.
Yixuan Ding +4 more
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Systemic analysis of the DNA replication regulator origin recognition complex in lung adenocarcinomas identifies prognostic and expression significance [PDF]
Cancer Medicine, 2023 Background DNA replication alteration is a hallmark of patients with lung adenocarcinoma (LUAD) and is frequently observed in LUAD progression. Origin recognition complex (ORC) 1, ORC2, ORC3, ORC4, ORC5, and ORC6 form a replication–initiator complex to ...
Min Tang +6 more
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Elevated origin recognition complex subunit 6 expression promotes non-small cell lung cancer cell growth [PDF]
Cell Death and DiseaseExploring novel targets for non-small cell lung cancer (NSCLC) remains of utmost importance. This study focused on ORC6 (origin recognition complex subunit 6), investigating its expression and functional significance within NSCLC.
Yong-hua Sang +6 more
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Structure of the active form of human origin recognition complex and its ATPase motor module [PDF]
eLife, 2017 Binding of the Origin Recognition Complex (ORC) to origins of replication marks the first step in the initiation of replication of the genome in all eukaryotic cells.
Ante Tocilj +7 more
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An Orc1 initiator-specific motif (ISM)-related region limits ORC–ssDNA binding and promotes replication origin specificity in budding yeast [PDF]
Frontiers in MicrobiologySingle-stranded DNA (ssDNA) is an essential intermediate of genome duplication but can also arise in the genome, including at highly transcribed loci. Although the origin recognition complex (ORC), a eukaryotic replication initiator, has been reported to
Hironori Kawakami +8 more
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A dual role for the chromatin reader ORCA/LRWD1 in targeting the origin recognition complex to chromatin. [PDF]
EMBO J, 2023 Sahu S +3 more
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