Results 31 to 40 of about 207,238 (265)
Origin Recognition Complex (ORC) Evolution Is Influenced by Global Gene Duplication/Loss Patterns in Eukaryotic Genomes. [PDF]
Genome Biol Evol, 2020 Ocaña-Pallarès E +8 more
europepmc +2 more sources
Conformational control and DNA-binding mechanism of the metazoan origin recognition complex. [PDF]
Proc Natl Acad Sci U S A, 2018 Bleichert F +4 more
europepmc +2 more sources
Crystal structure of the eukaryotic origin recognition complex. [PDF]
Nature, 2015 Initiation of cellular DNA replication is tightly controlled to sustain genomic integrity. In eukaryotes, the heterohexameric origin recognition complex (ORC) is essential for coordinating replication onset. Here we describe the crystal structure of Drosophila ORC at 3.5 Å resolution, showing that the 270 kilodalton initiator core complex comprises a ...
Bleichert F, Botchan MR, Berger JM.
europepmc +4 more sources
The origin recognition complex in human diseases. [PDF]
Biosci Rep, 2013 ORC (origin recognition complex) serves as the initiator for the assembly of the pre-RC (pre-replication complex) and the subsequent DNA replication. Together with many of its non-replication functions, ORC is a pivotal regulator of various cellular processes.
Shen Z.
europepmc +4 more sources
Assembly of the Human Origin Recognition Complex [PDF]
Journal of Biological Chemistry, 2001 The six-subunit origin recognition complex (ORC) was originally identified in the yeast Saccharomyces cerevisiae. Yeast ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors, such as Cdc6 and the Mcm proteins.
S, Vashee +3 more
openaire +2 more sources
The origin recognition complex protein family [PDF]
Genome Biology, 2009 Origin recognition complex (ORC) proteins were first discovered as a six-subunit assemblage in budding yeast that promotes the initiation of DNA replication. Orc1-5 appear to be present in all eukaryotes, and include both AAA+ and winged-helix motifs.
Duncker, Bernard P +2 more
openaire +2 more sources
Nature Communications, 2023 Chromatin replication involves the assembly and activity of the replisome within the nucleosomal landscape. At the core of the replisome is the Mcm2-7 complex (MCM), which is loaded onto DNA after binding to the Origin Recognition Complex (ORC). In yeast,
Humberto Sánchez +5 more
doaj +1 more source
The remarkable gymnastics of ORC
eLife, 2022 As a cell prepares to divide, a molecular actor known as the Origin Recognition Complex makes intricate ATP-driven movements to recruit proteins required to duplicate DNA.
Bruce Stillman
doaj +1 more source
Structural insight into the assembly and conformational activation of human origin recognition complex. [PDF]
Cell Discov, 2020 The function of the origin recognition complex (ORC) in DNA replication is highly conserved in recognizing and marking the initiation sites. The detailed molecular mechanisms by which human ORC is reconfigured into a state competent for origin ...
Cheng J +5 more
europepmc +2 more sources
Mathematical modelling of whole chromosome replication [PDF]
, 2010 All chromosomes must be completely replicated prior to cell division, a requirement that demands the activation of a sufficient number of appropriately distributed DNA replication origins.
de Moura, Alessandro P.S. +4 more
core +1 more source