Results 31 to 40 of about 1,409,521 (314)

The origin recognition complex: a biochemical and structural view. [PDF]

Subcell Biochem, 2012
The origin recognition complex (ORC) was first discovered in the baker's yeast in 1992. Identification of ORC opened up a path for subsequent molecular level investigations on how eukaryotic cells initiate and control genome duplication each cell cycle.
Li H, Stillman B.
europepmc   +5 more sources

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

eLife, 2013
In eukaryotes, DNA replication requires the origin recognition complex (ORC), a six-subunit assembly that promotes replisome formation on chromosomal origins.
Franziska Bleichert, Maxim Balasov, Igor Chesnokov, Eva Nogales, Michael R Botchan, James M Berger   +5 more
doaj   +2 more sources

Multi-omics analysis reveals the involvement of origin recognition complex subunit 6 in tumor immune regulation and malignant progression [PDF]

Frontiers in Immunology, 2023
BackgroundOrigin recognition complex 6 (ORC6) is one of the six highly conserved subunit proteins required for DNA replication and is essential for maintaining genome stability during cell division.
Jinfeng Zhu, Jinfeng Zhu, Qitong Chen, Qitong Chen, Liyun Zeng, Liyun Zeng, Hongyu Gao, Hongyu Gao, Tong Wu, Tong Wu, Yeqing He, Yeqing He, Jiachi Xu, Jiachi Xu, Jian Pang, Jian Pang, Jing Peng, Jing Peng, Yueqiong Deng, Yueqiong Deng, Yi Han, Yi Han, Wenjun Yi, Wenjun Yi   +23 more
doaj   +2 more sources

Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p [PDF]

BMC Biology, 2007
Background Histone modifications have been implicated in the regulation of transcription and, more recently, in DNA replication and repair. In yeast, a major conserved histone acetyltransferase, Hat1p, preferentially acetylates lysine residues 5 and 12 ...
Greenblatt Jack F, Lewis Peter, Krogan Nevan, Guo Xinghua, Pogoutse Oxana, Suter Bernhard, Rine Jasper, Emili Andrew   +7 more
doaj   +2 more sources

Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome

Nature Genetics, 2011
Louise S. Bicknell, Sarah Walker, Anna Klingseisen, Tom Stiff, Andrea Leitch, Claudia Kerzendorfer, Carol-Anne Martin, Patricia L. Yeyati, Nouriya Al Sanna, Michael B. Bober, Diana Johnson, Carol A. Wise, Andrew P. Jackson, Mark O’Driscoll, Penny A. Jeggo   +14 more
semanticscholar   +5 more sources

Origin recognition complex subunit 1 functions as an oncogenic driver and therapeutic target in cancer [PDF]

Discover Oncology
ORC1 is a core protein governing DNA replication initiation and cell cycle regulation, exhibiting significant overexpression in multiple malignancies where it correlates with advanced disease stage and poor prognosis.
Yixuan Ding, Shiwei Cai, Jinzhou Cai, Zhanpeng Wang, Zigui Zhu   +4 more
doaj   +2 more sources

The Cdc45·Mcm2–7·GINS Protein Complex in Trypanosomes Regulates DNA Replication and Interacts with Two Orc1-like Proteins in the Origin Recognition Complex [PDF]

Journal of Biological Chemistry, 2011
Accurate DNA replication requires a complex interplay of many regulatory proteins at replication origins. The CMG (Cdc45·Mcm2–7·GINS) complex, which is composed of Cdc45, Mcm2–7, and the GINS (Go-Ichi-Ni-San) complex consisting of Sld5 and Psf1 to Psf3 ...
Hung Quang Dang, Ziyin Li
openalex   +2 more sources

Elevated origin recognition complex subunit 6 expression promotes non-small cell lung cancer cell growth [PDF]

Cell Death and Disease
Exploring novel targets for non-small cell lung cancer (NSCLC) remains of utmost importance. This study focused on ORC6 (origin recognition complex subunit 6), investigating its expression and functional significance within NSCLC.
Yong-hua Sang, Chun-ying Luo, Bing-tao Huang, Siyang Wu, Jian Shu, Chang-gong Lan, Fuquan Zhang   +6 more
doaj   +2 more sources

ATP dependent assembly of the human origin recognition complex [PDF]

Journal of Biological Chemistry, 2007
The Origin Recognition Complex (ORC) was initially discovered in budding yeast extracts as a protein complex that binds with high affinity to Autonomously Replicating Sequences (ARS) in an ATP dependent manner.
Siddiqui, K., Stillman, B.
core   +4 more sources

Orc1 Binding to Mitotic Chromosomes Precedes Spatial Patterning during G1 Phase and Assembly of the Origin Recognition Complex in Human Cells. [PDF]

J Biol Chem, 2015
Background: Orc1 is the largest subunit of the origin recognition complex that promotes genome duplication. Results: We studied the dynamics of Orc1 during the cell division cycle. Conclusion: Orc1 binds to mitotic chromosomes, and during G1 phase in the
Kara N, Hossain M, Prasanth SG, Stillman B.   +3 more
europepmc   +2 more sources