Elevated origin recognition complex subunit 6 expression promotes non-small cell lung cancer cell growth [PDF]
Cell Death and DiseaseExploring novel targets for non-small cell lung cancer (NSCLC) remains of utmost importance. This study focused on ORC6 (origin recognition complex subunit 6), investigating its expression and functional significance within NSCLC.
Yong-hua Sang +6 more
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The origin recognition complex: a biochemical and structural view. [PDF]
Subcell Biochem, 2012 The origin recognition complex (ORC) was first discovered in the baker's yeast in 1992. Identification of ORC opened up a path for subsequent molecular level investigations on how eukaryotic cells initiate and control genome duplication each cell cycle.
Li H, Stillman B.
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RNA‐dependent recruitment of the origin recognition complex [PDF]
The EMBO Journal, 2008 The origin recognition complex (ORC) has an important function in determining the initiation sites of DNA replication. In higher eukaryotes, ORC lacks sequence-specific DNA binding, and the mechanisms of ORC recruitment and origin determination are poorly understood.
Julie, Norseen +5 more
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Structure of the active form of human origin recognition complex and its ATPase motor module [PDF]
eLife, 2017 Binding of the Origin Recognition Complex (ORC) to origins of replication marks the first step in the initiation of replication of the genome in all eukaryotic cells.
Ante Tocilj +7 more
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ATP-dependent Assembly of the Human Origin Recognition Complex [PDF]
Journal of Biological Chemistry, 2007 The origin recognition complex (ORC) was initially discovered in budding yeast extracts as a protein complex that binds with high affinity to autonomously replicating sequences in an ATP-dependent manner. We have cloned and expressed the human homologs of the ORC subunits as recombinant proteins. In contrast to other eukaryotic initiators examined thus
Khalid, Siddiqui, Bruce, Stillman
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An Orc1 initiator-specific motif (ISM)-related region limits ORC–ssDNA binding and promotes replication origin specificity in budding yeast [PDF]
Frontiers in MicrobiologySingle-stranded DNA (ssDNA) is an essential intermediate of genome duplication but can also arise in the genome, including at highly transcribed loci. Although the origin recognition complex (ORC), a eukaryotic replication initiator, has been reported to
Hironori Kawakami +8 more
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A dual role for the chromatin reader ORCA / LRWD1 in targeting the origin recognition complex to chromatin [PDF]
EMBO Journal, 2023 Babatunde Ekundayo +2 more
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Origin recognition complex subunit 6 (ORC6) is a key mediator of LPS-induced NFκB activation and the pro-inflammatory response [PDF]
Cell Communication and SignalingLipopolysaccharide (LPS)-activated pro-inflammatory responses play a critical role in sepsis, a life-threatening condition. This study investigates the role of origin recognition complex subunit 6 (ORC6) in LPS responses in macrophages and monocytes ...
Zichen Xie +4 more
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Origin recognition complex harbors an intrinsic nucleosome remodeling activity [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 Michael O'Donnell, Lu Bai, Shixin Liu
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Origin Recognition Complex (ORC) Evolution Is Influenced by Global Gene Duplication/Loss Patterns in Eukaryotic Genomes [PDF]
Genome Biology and Evolution, 2020 Eduard Ocaña-Pallarès +2 more
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