Results 31 to 40 of about 203,895 (232)
The remarkable gymnastics of ORC
eLife, 2022 As a cell prepares to divide, a molecular actor known as the Origin Recognition Complex makes intricate ATP-driven movements to recruit proteins required to duplicate DNA.
Bruce Stillman
doaj +1 more source
The origin recognition complex: from simple origins to complex functions [PDF]
Genes & Development, 2002 Eukaryotic DNA replication is an intricate process that requires the coordinate and tightly regulated action of numerous molecular machines. Eukaryotic cells must choose hundreds if not thousands of origins of replication and assemble multiple proteins or protein complexes at these sites. During S phase, these complexes are activated in a reproducible,
openaire +2 more sources
RNA‐dependent recruitment of the origin recognition complex [PDF]
The EMBO Journal, 2008 The origin recognition complex (ORC) has an important function in determining the initiation sites of DNA replication. In higher eukaryotes, ORC lacks sequence-specific DNA binding, and the mechanisms of ORC recruitment and origin determination are poorly understood.
Julie, Norseen +5 more
openaire +2 more sources
Nature Communications, 2023 The dynamics of DNA replication factors is crucial for cell cycle progression. Arabidopsis encode two origin recognition complex 1 proteins, ORC1a and ORC1b, with distinct roles in DNA replication and deposition of heterochromatic H3K27me1, respectively.
Zaida Vergara +10 more
doaj +1 more source
eLife, 2013 In eukaryotes, DNA replication requires the origin recognition complex (ORC), a six-subunit assembly that promotes replisome formation on chromosomal origins.
Franziska Bleichert +5 more
doaj +1 more source
Nucleosome-directed replication origin licensing independent of a consensus DNA sequence
Nature Communications, 2022 Most eukaryotes do not use a consensus DNA sequence as binding sites for the origin recognition complex (ORC) to initiate DNA replication, however budding yeast do. Here the authors show S. cerevisiae ORC can bind nucleosomes near nucleosome-free regions
Sai Li +5 more
doaj +1 more source
International Journal of General Medicine, 2021 Shaohua Chen,1,2 Ziyao Jin,3 Linfeng Xin,4 Lv Lv,2 Xuemei Zhang,3 Yizhen Gong,5 Jianlun Liu1 1Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nangning, People’s Republic of China; 2Department of Breast and Thyroid Surgery ...
Chen S +6 more
doaj
Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure. [PDF]
PLoS Genetics, 2010 Eukaryotic DNA replication origins differ both in their efficiency and in the characteristic time during S phase when they become active. The biological basis for these differences remains unknown, but they could be a consequence of chromatin structure ...
Nicolas M Berbenetz +2 more
doaj +1 more source
The role of adenosine triphosphate in the function of human origin recognition complex 4 protein [PDF]
Journal of the Serbian Chemical Society, 2010 Human origin recognition complex 4 (ORC4) protein, a subunit of the origin recognition complex, belongs to the AAA+ superfamily of adenosine triphosphate (ATP) ases.
ALEKSANDRA DIVAC +2 more
doaj
Abnormally proximal aortic origin of the brachiocephalic artery: Surgical implications
Annals of Pediatric Cardiology, 2022 Abnormal proximal aortic origin of the brachiocephalic artery is a very rare condition. It can occur in isolation or associated with complex congenital heart disease affecting the right ventricular outflow tract. Its recognition carries relevant surgical
Sudesh Prabhu +5 more
doaj +1 more source