Results 91 to 100 of about 1,409,521 (314)

Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins [PDF]

Proceedings of the National Academy of Sciences, 2008
In all eukaryotic cells, origins of DNA replication are characterized by the binding of the origin recognition complex (ORC). How ORC is positioned to sites where replication initiates is unknown, because metazoan ORC binds DNA without apparent sequence specificity. Thus, additional factors might be involved in ORC positioning.
Andreas W, Thomae, Dagmar, Pich, Jan, Brocher, Mark-Peter, Spindler, Christian, Berens, Robert, Hock, Wolfgang, Hammerschmidt, Aloys, Schepers   +7 more
openaire   +2 more sources

Structural basis of DNA replication origin recognition by human Orc6 protein binding with DNA

Nucleic Acids Research, 2020
The six-subunit origin recognition complex (ORC), a DNA replication initiator, defines the localization of the origins of replication in eukaryotes. The Orc6 subunit is the smallest and the least conserved among ORC subunits.
Naining Xu, Y. You, Changdong Liu, M. Balasov, Lee Tung Lun, Y. Geng, Chun Po Fung, Haitao Miao, Honglei Tian, To To Choy, Xiao Shi, Zhuming Fan, Bo Zhou, Katarina Akhmetova, R. Din, Hongyu Yang, Q. Hao, Peiyuan Qian, I. Chesnokov, G. Zhu   +19 more
semanticscholar   +1 more source

Financial Burden Associated With Hospitalisation Among Families of Childhood Brain Tumours in Australia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Families of children with cancer experience significant financial strain, even with universal healthcare. Indirect costs, such as productivity losses and non‐medical expenses, are rarely included in economic evaluations, and little is known about how effectively financial aid programmes alleviate this burden. Childhood brain tumours
Megumi Lim, Natalie Bradford, David Brain, Sameera Senanayake, Sanjeewa Kularatna, Kate Young, Christine Cashion, Tim Hassall, Susanna Cramb   +8 more
wiley   +1 more source

Architecture of the Yeast Origin Recognition Complex Bound to Origins of DNA Replication [PDF]

Molecular and Cellular Biology, 1997
In many organisms, the replication of DNA requires the binding of a protein called the initiator to DNA sites referred to as origins of replication. Analyses of multiple initiator proteins bound to their cognate origins have provided important insights into the mechanism by which DNA replication is initiated.
D G, Lee, S P, Bell
openaire   +2 more sources

An Orc1 initiator-specific motif (ISM)-related region limits ORC–ssDNA binding and promotes replication origin specificity in budding yeast

Frontiers in Microbiology
Single-stranded DNA (ssDNA) is an essential intermediate of genome duplication but can also arise in the genome, including at highly transcribed loci. Although the origin recognition complex (ORC), a eukaryotic replication initiator, has been reported to
Hironori Kawakami, Hironori Kawakami, Takeaki Chichibu, Ryuya Muraoka, Shota Kanamoto, Kanako Asada, Eiji Ohashi, Takuya Kurihara, Tsutomu Katayama   +8 more
doaj   +1 more source

Iridium complex, a phosphorescent light-emitting diode material, serves as a novel chemical probe for imaging hypoxic tumor tissues [PDF]

, 2007
Iridium complex, a promising organic light-emitting diode for next generation television displays, emits phosphorescence. Phosphorescence is quenched by oxygen. We used this oxygen-quenching feature for imaging tumor hypoxia.
Keigo Endo, Masahiro Hosaka, Seiji Tobita, Shaojuan Zhang, Toshitada Yoshihara, Toshiyuki Takeuchi, Yasuhiko Iida   +6 more
core   +1 more source

Systemic Analysis of the Dna Replication Regulators Origin Recognition Complex in Lung Adenocarcinomas Identifies Prognostic and Expression Significance [PDF]

, 2021
Yunbo Deng, Juan Chen, Xianyu Luo, Tian Zeng, Dongmei Ye, Yukun Li, Min Tang, Yu-ping Zhang   +7 more
openalex   +1 more source

Defining Roles in Pediatric Palliative Care: Perspectives From Oncology and Palliative Care Teams

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Early integration of pediatric palliative care (PPC) is associated with improved symptom management, quality of life, and healthcare utilization for children with cancer. Despite this, variation persists in how PPC is understood, operationalized, and integrated within pediatric oncology programs. In particular, ambiguity surrounding
Leeat Granek, Lori Wiener, Stephanie Veldhuijzen van Zanten, Donna Johnston, Fyeza Hasan, Adam Rapoport, Nathasha Datoo, Kimberley Widger, Sumit Gupta, Karen Fergus, Anthony K. C. Chan, Alisha Kassam, Emily McCullogh, Dave Lysecki   +13 more
wiley   +1 more source

Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

eLife, 2021
Eukaryotic DNA replication initiates during S phase from origins that have been licensed in the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, Mcm3, and Mcm7 with gene expression, replication timing, and fork ...
Nina Kirstein, Alexander Buschle, Xia Wu, Stefan Krebs, Helmut Blum, Elisabeth Kremmer, Ina M Vorberg, Wolfgang Hammerschmidt, Laurent Lacroix, Olivier Hyrien, Benjamin Audit, Aloys Schepers   +11 more
doaj   +1 more source

Protein import into chloroplasts: new aspects of a well-known topic [PDF]

, 2007
Protein import into plant chloroplasts is a fascinating topic that is being investigated by many research groups. Since the majority of chloroplast proteins are synthesised as precursor proteins in the cytosol, they have to be posttranslationally ...
Bölter, Bettina, Soil, Juergen, Stengel, Anna   +2 more
core   +1 more source