Results 101 to 110 of about 196,060 (141)

Molecular impacts of Meier-Gorlin syndrome mutations on human origin licensing. [PDF]

J Biol Chem
Yang R, Hunker O, Kim J, Bleichert F.
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Mysterious Leishmania martiniquensis parasites and their relatives of the subgenus Mundinia: Emerging pathogens reshaping our understanding of leishmaniases. [PDF]

PLoS Pathog
Volf P, Sadlova J.
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Reducing uncertainty in assessment of occupational diseases informs prevention. [PDF]

Occup Med (Lond)
van der Molen HF, Kezic S, Heederik DJJ.
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Replication origin flexibility: a tool to mitigate the hazards of excess replication. [PDF]

Trends Genet
Fu H, Redon CE, Brenner HM, Ack MR, Aladjem MI.   +4 more
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Characterisation of Xenopus Origin Recognition Complex

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Structure of the origin recognition complex bound to DNA replication origin

Nature, 2018
The six-subunit origin recognition complex (ORC) binds to DNA to mark the site for the initiation of replication in eukaryotes. Here we report a 3 Å cryo-electron microscopy structure of the Saccharomyces cerevisiae ORC bound to a 72-base-pair origin DNA sequence that contains the ARS consensus sequence (ACS) and the B1 element.
Li, Ningning, Lam, Wai Hei, Zhai, Yuanliang, Cheng, Jiaxuan, Cheng, Erchao, Zhao, Yongqian, Gao, Ning, Tye Yeung, Bik Kwoon   +7 more
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The many faces of the origin recognition complex

Current Opinion in Cell Biology, 2007
The hetero-hexameric origin recognition complex (ORC) is well known for its separable roles in DNA replication and heterochromatin assembly. However, ORC and its individual subunits have been implicated in diverse cellular activities in both the nucleus and the cytoplasm.
Takayo, Sasaki, David M, Gilbert
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ADP-binding to Origin Recognition Complex of Saccharomyces cerevisiae

Journal of Molecular Biology, 2004
The origin recognition complex (ORC), a possible initiator of chromosomal DNA replication in eukaryotes, binds to ATP through its subunits Orc1p and Orc5p. Orc1p possesses ATPase activity. As for DnaA, the Escherichia coli initiator, the ATP-DnaA complex is active but the ADP-DnaA complex is inactive for DNA replication and, therefore, the ATPase ...
Hitomi, Takenaka, Masaki, Makise, Wakako, Kuwae, Naoko, Takahashi, Tomofusa, Tsuchiya, Tohru, Mizushima   +5 more
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Separation of Origin Recognition Complex Functions by Cross-Species Complementation

Science, 1995
Transcriptional silencing at the HMR a locus of Saccharomyces cerevisiae requires the function of the origin recognition complex (ORC), the replication initiator of yeast. Expression of a Drosophila melanogaster Orc2 complementary DNA in the yeast orc2-1
Ehrenhofer-Murray, Ann, Gossen, Manfred, Pak, Daniel T. S., Botchan, Michael R., Rine, Jasper   +4 more
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A Drosophila Homolog of the Yeast Origin Recognition Complex

Science, 1995
Genes from Drosophila melanogaster have been identified that encode proteins homologous to Orc2p and Orc5p of the Saccharomyces cerevisiae origin recognition complex (ORC). The abundance of the Drosophila Orc2p homolog DmORC2 is developmentally regulated and is ...
M, Gossen, D T, Pak, S K, Hansen, J K, Acharya, M R, Botchan   +4 more
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