Results 111 to 120 of about 196,060 (141)

Multiple Functions of the Origin Recognition Complex

2007
The origin recognition complex (ORC), a heteromeric six-subunit protein, is a central component for eukaryotic DNA replication. The ORC binds to DNA at replication origin sites in an ATP-dependent manner and serves as a scaffold for the assembly of other key initiation factors. Sequence rules for ORC-DNA binding appear to vary widely.
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Yeast Origin Recognition Complex Functions in Transcription Silencing and DNA Replication

Science, 1993
The genes encoding two of the subunits of the Saccharomyces cerevisiae origin recognition complex (ORC) have been isolated. Characterization of a temperature-sensitive mutation in the gene encoding the 72-kD subunit of ORC ( ORC2 ) indicates that this protein complex functions early in the ...
S P, Bell, R, Kobayashi, B, Stillman
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Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome

Nature Genetics, 2011
Meier-Gorlin syndrome is a rare autosomal recessive genetic condition whose primary clinical hallmarks include small stature, small external ears and small or absent patellae. Using marker-assisted mapping in multiple families from a founder population and traditional coding exon sequencing of positional candidate genes, we identified three different ...
Duane L, Guernsey, Makoto, Matsuoka, Haiyan, Jiang, Susan, Evans, Christine, Macgillivray, Mathew, Nightingale, Scott, Perry, Meghan, Ferguson, Marissa, LeBlanc, Jean, Paquette, Lysanne, Patry, Andrea L, Rideout, Aidan, Thomas, Andrew, Orr, Chris R, McMaster, Jacques L, Michaud, Cheri, Deal, Sylvie, Langlois, Duane W, Superneau, Sandhya, Parkash, Mark, Ludman, David L, Skidmore, Mark E, Samuels   +22 more
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Replication Origin Recognition and Deformation by a Heterodimeric Archaeal Orc1 Complex

Science, 2007
The faithful duplication of genetic material depends on essential DNA replication initiation factors. Cellular initiators form higher-order assemblies on replication origins, using adenosine triphosphate (ATP) to locally remodel duplex DNA and facilitate proper loading of synthetic replisomal components.
Erin L Cunningham, Dueber, Jacob E, Corn, Stephen D, Bell, James M, Berger   +3 more
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Replication | DNA Replication: Eukaryotic Origins and the Origin Recognition Complex

2021
Igor Chesnokov, Katarina Akhmetova
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Mechanism of replication origin melting nucleated by CMG helicase assembly

Nature, 2022
Jacob S Lewis, Sarah S Henrikus, Julia F Greiwe   +2 more
exaly  

Origin Recognition Complex

2011
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Origin Recognition Complex Subunit 6

2020
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Origin Recognition Complex

2006
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ORC (origin recognition complex)

2008
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