Results 121 to 130 of about 1,024,488 (281)

Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus [PDF]

, 2001
Aloys Schepers
openalex   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Kaplan's Sloppy Thinker and the Demonstrative Origine of Indeicals [PDF]

, 2017
In this paper we give some suggestions from etymology on the contrast between Kaplan’s direct reference theory and a neo-Fregean view on indexicals.
Borghi, Guido, Penco, Carlo
core  

Delayed recognition of complex staphylococcal infection in pyrexia of unknown origin

The Indian Anaesthetists' Forum, 2020
Vanita Ahuja, Kavita Ramakrishna Bhagwat, Pawanpreet Kaur, Karanjot Gill   +3 more
doaj   +1 more source

Temporal control of human DNA replication licensing by CDK4/6-RB signalling and chemical genetics

Nature Communications
Cyclin-dependent kinases (CDKs) coordinate DNA replication and cell division, and play key roles in tissue homeostasis, genome stability and cancer development.
Anastasia Sosenko Piscitello, Ann-Sofie Nilsson, Michael Hawgood, Abid H. Sayyid, Vasilis S. Dionellis, Giovanni Giglio, Bruno Urién, Pratikiran Bajgain, Sotirios G. Ntallis, Jiri Bartek, Thanos D. Halazonetis, Bennie Lemmens   +11 more
doaj   +1 more source

Assembly of the Human Origin Recognition Complex [PDF]

, 2001
Sanjay Vashee, Pamela Simancek, M D Challberg, Thomas J. Kelly   +3 more
openalex   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

The Common European Asylum System: Inconsistent, incoherent and lacking credibility [PDF]

, 2018
There are two distinct but related issues here: the diverse probabilities of receiving protection in the EU depending on the country in which one makes a claim, and the credibility of decisions that are made.
Schuster, L.
core  

Expression and Clinical Significance of Origin Recognition Complex Subunit 6 in Breast Cancer - A Comprehensive Bioinformatics Analysis. [PDF]

Int J Gen Med, 2021
Chen S, Jin Z, Xin L, Lv L, Zhang X, Gong Y, Liu J.   +6 more
europepmc   +1 more source