Results 171 to 180 of about 1,409,521 (314)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Temporal control of human DNA replication licensing by CDK4/6-RB signalling and chemical genetics

Nature Communications
Cyclin-dependent kinases (CDKs) coordinate DNA replication and cell division, and play key roles in tissue homeostasis, genome stability and cancer development.
Anastasia Sosenko Piscitello, Ann-Sofie Nilsson, Michael Hawgood, Abid H. Sayyid, Vasilis S. Dionellis, Giovanni Giglio, Bruno Urién, Pratikiran Bajgain, Sotirios G. Ntallis, Jiri Bartek, Thanos D. Halazonetis, Bennie Lemmens   +11 more
doaj   +1 more source

Expression and Clinical Significance of Origin Recognition Complex Subunit 6 in Breast Cancer - A Comprehensive Bioinformatics Analysis. [PDF]

Int J Gen Med, 2021
Chen S, Jin Z, Xin L, Lv L, Zhang X, Gong Y, Liu J.   +6 more
europepmc   +1 more source

Xenopus origin recognition complex (ORC) initiates DNA replication preferentially at sequences targeted by Schizosaccharomyces pombe ORC [PDF]

, 2003
Dong Kong
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Evolution of the Eukaryotic Origin Recognition Complex [PDF]

Biophysical Journal, 2020
Bik-Kwoon Tye, Shuk Kwan C. Lee, Wai Hei H. Lam, Yuanliang Zhai   +3 more
openaire   +1 more source

Identification and in silico analysis of the origin recognition complex in the human fungal pathogen Candida albicans. [PDF]

MicroPubl Biol, 2021
Padmanabhan S, Sanyal K, Dubey D.
europepmc   +1 more source

Activation of Replication Origins in ϕ29-related Phages Requires the Recognition of Initiation Proteins to Specific Nucleoprotein Complexes [PDF]

, 1996
Raimundo Freire, Manuel Serrano, Margarita Salas, José M. Hermoso   +3 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Origin recognition complex 1 regulates phospholipase Cδ1 to inhibit cell proliferation, migration and epithelial-mesenchymal transition in lung adenocarcinoma. [PDF]

Oncol Lett, 2022
Jian Y, Qiao Q, Tang J, Qin X.
europepmc   +1 more source