Results 201 to 210 of about 203,895 (232)

Characterization of a Goose-Origin Avian Orthoreovirus with Interferon Suppression Activity. [PDF]

open access: yesViruses
Liu Y   +10 more
europepmc   +1 more source

The metazoan origin recognition complex [PDF]

open access: yesFrontiers in Bioscience - Landmark, 1999
Regulated initiation of DNA replication relies on the firing of initiator proteins that bind specifically to origin DNA. The discovery of the first eukaryotic initiator, the Saccharomyces cerevisiae Origin Recognition Complex (ORC) has allowed us to discern some aspects of how the onset of replication is regulated.
Anindya Dutta, David G Quintana
exaly   +3 more sources
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Structure of the origin recognition complex bound to DNA replication origin

Nature, 2018
The six-subunit origin recognition complex (ORC) binds to DNA to mark the site for the initiation of replication in eukaryotes. Here we report a 3 Å cryo-electron microscopy structure of the Saccharomyces cerevisiae ORC bound to a 72-base-pair origin DNA sequence that contains the ARS consensus sequence (ACS) and the B1 element.
Tye Bik Kwoon   +2 more
exaly   +4 more sources

Multiple Functions of the Origin Recognition Complex

International Review of Cytology, 2007
The origin recognition complex (ORC), a heteromeric six-subunit protein, is a central component for eukaryotic DNA replication. The ORC binds to DNA at replication origin sites in an ATP-dependent manner and serves as a scaffold for the assembly of other key initiation factors. Sequence rules for ORC-DNA binding appear to vary widely.
exaly   +3 more sources

The many faces of the origin recognition complex

Current Opinion in Cell Biology, 2007
The hetero-hexameric origin recognition complex (ORC) is well known for its separable roles in DNA replication and heterochromatin assembly. However, ORC and its individual subunits have been implicated in diverse cellular activities in both the nucleus and the cytoplasm.
Takayo, Sasaki, David M, Gilbert
openaire   +2 more sources

ADP-binding to Origin Recognition Complex of Saccharomyces cerevisiae

Journal of Molecular Biology, 2004
The origin recognition complex (ORC), a possible initiator of chromosomal DNA replication in eukaryotes, binds to ATP through its subunits Orc1p and Orc5p. Orc1p possesses ATPase activity. As for DnaA, the Escherichia coli initiator, the ATP-DnaA complex is active but the ADP-DnaA complex is inactive for DNA replication and, therefore, the ATPase ...
Hitomi, Takenaka   +5 more
openaire   +2 more sources

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