Colorimetric sensor array combined with machine learning for discriminating the geographical origins and grape varieties of Chinese red wines. [PDF]
Meng Z +8 more
europepmc +1 more source
Geographical Origin Traceability of Tea (<i>Camellia sinensis</i>): A Comprehensive Review of Analytical Techniques, Chemometric Approaches, and Future Perspectives. [PDF]
Chen H +7 more
europepmc +1 more source
Characterization of a Goose-Origin Avian Orthoreovirus with Interferon Suppression Activity. [PDF]
Liu Y +10 more
europepmc +1 more source
The metazoan origin recognition complex [PDF]
Regulated initiation of DNA replication relies on the firing of initiator proteins that bind specifically to origin DNA. The discovery of the first eukaryotic initiator, the Saccharomyces cerevisiae Origin Recognition Complex (ORC) has allowed us to discern some aspects of how the onset of replication is regulated.
Anindya Dutta, David G Quintana
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Structure of the origin recognition complex bound to DNA replication origin
Nature, 2018The six-subunit origin recognition complex (ORC) binds to DNA to mark the site for the initiation of replication in eukaryotes. Here we report a 3 Å cryo-electron microscopy structure of the Saccharomyces cerevisiae ORC bound to a 72-base-pair origin DNA sequence that contains the ARS consensus sequence (ACS) and the B1 element.
Tye Bik Kwoon +2 more
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Multiple Functions of the Origin Recognition Complex
International Review of Cytology, 2007The origin recognition complex (ORC), a heteromeric six-subunit protein, is a central component for eukaryotic DNA replication. The ORC binds to DNA at replication origin sites in an ATP-dependent manner and serves as a scaffold for the assembly of other key initiation factors. Sequence rules for ORC-DNA binding appear to vary widely.
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The many faces of the origin recognition complex
Current Opinion in Cell Biology, 2007The hetero-hexameric origin recognition complex (ORC) is well known for its separable roles in DNA replication and heterochromatin assembly. However, ORC and its individual subunits have been implicated in diverse cellular activities in both the nucleus and the cytoplasm.
Takayo, Sasaki, David M, Gilbert
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Replication | DNA Replication: Eukaryotic Origins and the Origin Recognition Complex
2021Igor Chesnokov, Katarina Akhmetova
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ADP-binding to Origin Recognition Complex of Saccharomyces cerevisiae
Journal of Molecular Biology, 2004The origin recognition complex (ORC), a possible initiator of chromosomal DNA replication in eukaryotes, binds to ATP through its subunits Orc1p and Orc5p. Orc1p possesses ATPase activity. As for DnaA, the Escherichia coli initiator, the ATP-DnaA complex is active but the ADP-DnaA complex is inactive for DNA replication and, therefore, the ATPase ...
Hitomi, Takenaka +5 more
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