Results 241 to 250 of about 207,238 (265)

The metazoan origin recognition complex [PDF]

Frontiers in Bioscience - Landmark, 1999
Regulated initiation of DNA replication relies on the firing of initiator proteins that bind specifically to origin DNA. The discovery of the first eukaryotic initiator, the Saccharomyces cerevisiae Origin Recognition Complex (ORC) has allowed us to discern some aspects of how the onset of replication is regulated.
David G Quintana, Anindya Dutta
exaly   +3 more sources

Expression and characterization of human malaria parasite Plasmodium falciparum origin recognition complex subunit 1

Biochemical and Biophysical Research Communications, 2005
In eukaryotes, the origin recognition complex (ORC) is essential for the initiation of DNA replication. The largest subunit of this complex (ORC1) has a regulatory role in origin activation.
Parul Mehra, Ashish Gupta, Samudrala Gourinath   +2 more
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Multiple Functions of the Origin Recognition Complex

International Review of Cytology, 2007
The origin recognition complex (ORC), a heteromeric six-subunit protein, is a central component for eukaryotic DNA replication. The ORC binds to DNA at replication origin sites in an ATP-dependent manner and serves as a scaffold for the assembly of other key initiation factors. Sequence rules for ORC-DNA binding appear to vary widely.
exaly   +3 more sources

The many faces of the origin recognition complex

Current Opinion in Cell Biology, 2007
The hetero-hexameric origin recognition complex (ORC) is well known for its separable roles in DNA replication and heterochromatin assembly. However, ORC and its individual subunits have been implicated in diverse cellular activities in both the nucleus and the cytoplasm.
Takayo, Sasaki, David M, Gilbert
openaire   +2 more sources

ADP-binding to Origin Recognition Complex of Saccharomyces cerevisiae

Journal of Molecular Biology, 2004
The origin recognition complex (ORC), a possible initiator of chromosomal DNA replication in eukaryotes, binds to ATP through its subunits Orc1p and Orc5p. Orc1p possesses ATPase activity. As for DnaA, the Escherichia coli initiator, the ATP-DnaA complex is active but the ADP-DnaA complex is inactive for DNA replication and, therefore, the ATPase ...
Hitomi, Takenaka, Masaki, Makise, Wakako, Kuwae, Naoko, Takahashi, Tomofusa, Tsuchiya, Tohru, Mizushima   +5 more
openaire   +2 more sources

Replication Origin Recognition and Deformation by a Heterodimeric Archaeal Orc1 Complex

Science, 2007
The faithful duplication of genetic material depends on essential DNA replication initiation factors. Cellular initiators form higher-order assemblies on replication origins, using adenosine triphosphate (ATP) to locally remodel duplex DNA and facilitate proper loading of synthetic replisomal components.
Erin L Cunningham, Dueber, Jacob E, Corn, Stephen D, Bell, James M, Berger   +3 more
openaire   +2 more sources

The Origin Recognition Complex in the Initiation of DNA Replication

2016
The origin recognition complex (ORC) is the six-subunit heteromeric protein complex that binds directly to the positions on eukaryotic chromosomes where the protein-DNA complex required for the activation of DNA replication origins assembles. This protein-DNA complex, named the MCM complex, contains the replicative helicases and performs the actual ...
Timothy Hoggard, Catherine A. Fox
openaire   +1 more source

Investigation of the Interaction of Human Origin Recognition Complex Subunit 1 with G-Quadruplex DNAs of Human c-myc Promoter and Telomere Regions

International Journal of Molecular Sciences, 2021
Yudai Yamaoki, Keiko Kondo, Shou Waga
exaly  

Origin Recognition Complex

2011
openaire   +1 more source

Replication | DNA Replication: Eukaryotic Origins and the Origin Recognition Complex

2021
Igor Chesnokov, Katarina Akhmetova
openaire   +1 more source