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Characterisation of Xenopus Origin Recognition Complex

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The many faces of the origin recognition complex

Current Opinion in Cell Biology, 2007
The hetero-hexameric origin recognition complex (ORC) is well known for its separable roles in DNA replication and heterochromatin assembly. However, ORC and its individual subunits have been implicated in diverse cellular activities in both the nucleus and the cytoplasm.
Takayo, Sasaki, David M, Gilbert
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Structure of the origin recognition complex bound to DNA replication origin

Nature, 2018
The six-subunit origin recognition complex (ORC) binds to DNA to mark the site for the initiation of replication in eukaryotes. Here we report a 3 Å cryo-electron microscopy structure of the Saccharomyces cerevisiae ORC bound to a 72-base-pair origin DNA sequence that contains the ARS consensus sequence (ACS) and the B1 element.
Li, Ningning, Lam, Wai Hei, Zhai, Yuanliang, Cheng, Jiaxuan, Cheng, Erchao, Zhao, Yongqian, Gao, Ning, Tye Yeung, Bik Kwoon   +7 more
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ADP-binding to Origin Recognition Complex of Saccharomyces cerevisiae

Journal of Molecular Biology, 2004
The origin recognition complex (ORC), a possible initiator of chromosomal DNA replication in eukaryotes, binds to ATP through its subunits Orc1p and Orc5p. Orc1p possesses ATPase activity. As for DnaA, the Escherichia coli initiator, the ATP-DnaA complex is active but the ADP-DnaA complex is inactive for DNA replication and, therefore, the ATPase ...
Hitomi, Takenaka, Masaki, Makise, Wakako, Kuwae, Naoko, Takahashi, Tomofusa, Tsuchiya, Tohru, Mizushima   +5 more
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Separation of Origin Recognition Complex Functions by Cross-Species Complementation

Science, 1995
Transcriptional silencing at the HMR a locus of Saccharomyces cerevisiae requires the function of the origin recognition complex (ORC), the replication initiator of yeast. Expression of a Drosophila melanogaster Orc2 complementary DNA in the yeast orc2-1
Ehrenhofer-Murray, Ann, Gossen, Manfred, Pak, Daniel T. S., Botchan, Michael R., Rine, Jasper   +4 more
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A Drosophila Homolog of the Yeast Origin Recognition Complex

Science, 1995
Genes from Drosophila melanogaster have been identified that encode proteins homologous to Orc2p and Orc5p of the Saccharomyces cerevisiae origin recognition complex (ORC). The abundance of the Drosophila Orc2p homolog DmORC2 is developmentally regulated and is ...
M, Gossen, D T, Pak, S K, Hansen, J K, Acharya, M R, Botchan   +4 more
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Multiple Functions of the Origin Recognition Complex

2007
The origin recognition complex (ORC), a heteromeric six-subunit protein, is a central component for eukaryotic DNA replication. The ORC binds to DNA at replication origin sites in an ATP-dependent manner and serves as a scaffold for the assembly of other key initiation factors. Sequence rules for ORC-DNA binding appear to vary widely.
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Yeast Origin Recognition Complex Functions in Transcription Silencing and DNA Replication

Science, 1993
The genes encoding two of the subunits of the Saccharomyces cerevisiae origin recognition complex (ORC) have been isolated. Characterization of a temperature-sensitive mutation in the gene encoding the 72-kD subunit of ORC ( ORC2 ) indicates that this protein complex functions early in the ...
S P, Bell, R, Kobayashi, B, Stillman
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Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome

Nature Genetics, 2011
Meier-Gorlin syndrome is a rare autosomal recessive genetic condition whose primary clinical hallmarks include small stature, small external ears and small or absent patellae. Using marker-assisted mapping in multiple families from a founder population and traditional coding exon sequencing of positional candidate genes, we identified three different ...
Duane L, Guernsey, Makoto, Matsuoka, Haiyan, Jiang, Susan, Evans, Christine, Macgillivray, Mathew, Nightingale, Scott, Perry, Meghan, Ferguson, Marissa, LeBlanc, Jean, Paquette, Lysanne, Patry, Andrea L, Rideout, Aidan, Thomas, Andrew, Orr, Chris R, McMaster, Jacques L, Michaud, Cheri, Deal, Sylvie, Langlois, Duane W, Superneau, Sandhya, Parkash, Mark, Ludman, David L, Skidmore, Mark E, Samuels   +22 more
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Replication Origin Recognition and Deformation by a Heterodimeric Archaeal Orc1 Complex

Science, 2007
The faithful duplication of genetic material depends on essential DNA replication initiation factors. Cellular initiators form higher-order assemblies on replication origins, using adenosine triphosphate (ATP) to locally remodel duplex DNA and facilitate proper loading of synthetic replisomal components.
Erin L Cunningham, Dueber, Jacob E, Corn, Stephen D, Bell, James M, Berger   +3 more
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