Results 41 to 50 of about 14,422 (161)

Pre-Pandemic Cross-Reactive Immunity against SARS-CoV-2 among Central and West African Populations

Viruses, 2022
For more than two years after the emergence of COVID-19 (Coronavirus Disease-2019), significant regional differences in morbidity persist. These differences clearly show lower incidence rates in several regions of the African and Asian continents.
Marc Souris, Léon Tshilolo, Daniel Parzy, Line Lobaloba Ingoba, Francine Ntoumi, Rachel Kamgaing, Moussa Ndour, Destin Mbongi, Balthazar Phoba, Marie-Anasthasie Tshilolo, René Mbungu, Martin Samuel Sosso, Nadine Fainguem, Tandakha Ndiaye Dieye, Massamba Sylla, Pierre Morand, Jean-Paul Gonzalez   +16 more
doaj   +1 more source

Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic. [PDF]

, 2018
Recent outbreaks of H5, H7, and H9 influenza A viruses in humans have served as a vivid reminder of the potentially devastating effects that a novel pandemic could exert on the modern world.
Alain Gagnon, D. Ann Herring, David J. D. Earn, Enrique Acosta, Joaquin Madrenas, Kris Inwood, Lisa Y. Dillon, Matthew S. Miller, Nadine Ouellette, Robert Bourbeau, Stacey Hallman, W. Ian Lipkin   +11 more
core   +3 more sources

Heterotypic Neuraminidase Antibodies Against Different A(H1N1) Strains are Elicited after Seasonal Influenza Vaccination

Vaccines, 2019
Neuraminidase (NA) content is not standardized in current seasonal influenza vaccines; neither anti-NA antibodies (anti-NA Abs) are measured nor is it well-defined as a correlate of humoral protection. In this work, the presence of NA1 antibodies against
Jose Manuel Mendez-Legaza, Raúl Ortiz de Lejarazu, Ivan Sanz   +2 more
doaj   +1 more source

Immunogenicity of NS4b dengue 3 virus mimotope presented to the immune system as multiple antigen peptide system [PDF]

, 2013
The availability of random peptide libraries displayed on bacteriophage (RPL) has provided a powerful tool for selecting sequences that mimic binding properties of natural antigen epitopes (mimotopes). These mimotopes can be used for vaccine design, drug
Acosta, Armando, Aguilar, Alicia, Alvarez, Mayling, Amin, Nevis, Caballero, Yamira, Camacho, Frank, Díaz, Daiyana, García, Angélica, Guzmán, María Guadalupe, Pupo, Maritza, Reyes, Osvalda, Stott, David I.   +11 more
core   +2 more sources

Original antigenic sin: A comprehensive review

Journal of Autoimmunity, 2017
The concept of "original antigenic sin" was first proposed by Thomas Francis, Jr. in 1960. This phenomenon has the potential to rewrite what we understand about how the immune system responds to infections and its mechanistic implications on how vaccines should be designed.
Vatti A., Monsalve Carmona, Diana Marcela, Pacheco Y., Chang C., Anaya, Juan-Manuel, Gershwin M.E.   +5 more
openaire   +2 more sources

Cross protection to SARS-CoV-2 variants in hamsters with naturally-acquired immunity

Virology Journal, 2023
Since SARS-CoV-2 was first reported in late 2019, multiple variations of the original virus have emerged. Each variant harbors accumulations of mutations, particularly within the spike glycoprotein, that are associated with increased viral ...
Saina Beitari, Diana Duque, Jegarubee Bavananthasivam, Melissa Hewitt, Jagdeep K. Sandhu, Ita Hadžisejdić, Anh Tran   +6 more
doaj   +1 more source

Variation in dengue virus plaque reduction neutralization testing: systematic review and pooled analysis. [PDF]

, 2012
BackgroundThe plaque reduction neutralization test (PRNT) remains the gold standard for the detection of serologic immune responses to dengue virus (DENV).
Cummings, Derek AT, Lessler, Justin, Rainwater-Lovett, Kaitlin, Rodriguez-Barraquer, Isabel   +3 more
core   +3 more sources

Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. [PDF]

, 2009
BackgroundProstate stem/progenitor cells function in glandular development and maintenance. They may be targets for tumor initiation, so characterization of these cells may have therapeutic implications.
Garraway, Isla P, Goldstein, Andrew S, Hahm, Scott A, Haider, Maahum, Head, Christian S, Perner, Sven, Reiter, Robert E, Rubin, Mark A, Sun, Wenyi, Tran, Chau P, Witte, Owen N, Zhang, Bao   +11 more
core   +1 more source

Vaccine-induced neutralizing antibody responses to seasonal influenza virus H1N1 strains are not enhanced during subsequent pandemic H1N1 infection

Frontiers in Immunology, 2023
The first exposure to influenza is presumed to shape the B-cell antibody repertoire, leading to preferential enhancement of the initially formed responses during subsequent exposure to viral variants.
Petra Mooij, Daniella Mortier, Aafke Aartse, Aafke Aartse, Alexandre B. Murad, Alexandre B. Murad, Ricardo Correia, Ricardo Correia, António Roldão, António Roldão, Paula M. Alves, Paula M. Alves, Zahra Fagrouch, Dirk Eggink, Dirk Eggink, Norbert Stockhofe, Othmar G. Engelhardt, Ernst J. Verschoor, Marit J. van Gils, Marit J. van Gils, Willy M. Bogers, Manuel J. T. Carrondo, Edmond J. Remarque, Gerrit Koopman   +23 more
doaj   +1 more source

Determinants of Influenza Mortality Trends: Age-Period-Cohort Analysis of Influenza Mortality in the United States, 1959-2016. [PDF]

, 2019
This study examines the roles of age, period, and cohort in influenza mortality trends over the years 1959-2016 in the United States. First, we use Lexis surfaces based on Serfling models to highlight influenza mortality patterns as well as to identify ...
Acosta, Enrique, Bourbeau, Robert, Dillon, Lisa Y, Earn, David JD, Gagnon, Alain, Hallman, Stacey A, Herring, D Ann, Inwood, Kris, Madrenas, Joaquin, Miller, Matthew S, Ouellette, Nadine   +10 more
core   +1 more source