Results 31 to 40 of about 1,431,470 (343)

Prebiotic competition and evolution in self-replicating polynucleotides can explain the properties of DNA/RNA in modern living systems

BMC Evolutionary Biology, 2020
Background We hypothesize prebiotic evolution of self-replicating macro-molecules (Alberts, Molecular biology of the cell, 2015; Orgel, Crit Rev Biochem Mol Biol 39:99-123, 2004; Hud, Nat Commun 9:5171) favoured the constituent nucleotides and ...
Hemachander Subramanian, Joel Brown, Robert Gatenby   +2 more
doaj   +1 more source

The origin of compression influences geometric instabilities in bilayers [PDF]

, 2018
Geometric instabilities in bilayered structures control the surface morphology in a wide range of biological and technical systems. Depending on the application, different mechanisms induce compressive stresses in the bilayer.
Andres, Sebastian, Budday, Silvia, Steinmann, Paul   +2 more
core   +1 more source

The building blocks and origins of life

HTS Teologiese Studies/Theological Studies, 2020
The building blocks and origins of life have fascinated scientists since the earliest of times. What is required for life to work in terms of building blocks?
Dirk U. Bellstedt
doaj   +1 more source

Thermodynamic origin of life [PDF]

, 2010
Abstract. Understanding the thermodynamic function of life may shed light on its origin. Life, as are all irreversible processes, is contingent on entropy production. Entropy production is a measure of the rate of the tendency of Nature to explore available microstates.
openaire   +2 more sources

Magnetism, FeS colloids, and Origins of Life

, 2010
A number of features of living systems: reversible interactions and weak bonds underlying motor-dynamics; gel-sol transitions; cellular connected fractal organization; asymmetry in interactions and organization; quantum coherent phenomena; to name some ...
A Ahniyaz, A Engel, A Etxeberria, A Nagya, A Preisinger, A Pross, A Yethiraj, AD Patel, AD Patel, AD Patel, AG Cairns-Smith, AJ Boyce, AJ Boyce, AL Buchachenko, AM Selvam, AM Tishin, AP Roberts, AS Keys, AY Zubarev, AY Zubarev, B-O Küppers, BA Grzybowski, C Bustamante, C Huber, C Jaryznski, C Tenailleau, C Viedma, CR Vestal, D Abel, D Abel, D Rickard, D Rickard, D Rickard, den Hollander WThF, DG Drubin, DI Khomskii, DJ Vaughan, DJ Vaughan, DL Stein, DS Kelley, E Schroedinger, EJ Milner-White, EJ Milner-White, ET Degens, EV Koonin, F Heylighen, FJ Dyson, FM Harold, G Mitra-Delmotte, G Nicolis, G Wächtershäuser, GL Früh-Green, GN Ling, GO Arrhenius, GS Engel, H Frohlich, H Frohlich, H Ohfuji, H Ohfuji, H Ohldag, HH Pattee, HH Pattee, HM Palmer, I Adler, I Kant, IK Kominis, J Al-Khalili, J Breivik, J Charnock, J Cheon, J Dyment, J Hemberger, J Higo, J Hoffmeyer, J Li, J McFadden, J Spitzer, J Torbet, JC Weaver, JD Bernal, JK Jain, JL Kirschvink, JL Kirschvink, JL Kirschvink, JM McBride, JP Ferris, JS Ban, JS Beard, JT Trevors, K Hatori, K Matsuno, K Righter, KA Michie, KM Doll, LE Orgel, LE Orgel, LE Orgel, LS Levitov, M Haw, M Jibu, M Mostovoy, M Polyani, M Winkelhofer, M Wolthers, M Wu, MF Chaplin, MF Chaplin, Mitra-Delmotte, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MO Goerbig, MP Pileni, NE Mavromatos, NJ Cerf, P Baaske, P Bak, P Galland, P Wasilewski, PCW Davies, PCW Davies, PCW Davies, PW Anderson, R Hazen, R Kopelman, R Lifshitz, R Palm, R Pastor-Satorras, R Phillips, R Shapiro, R Skomski, RA Dunlap, RCL Larter, RD Astumian, RD Astumian, RE Rosensweig, RT Wilkin, RW Chantrell, S Hagan, S Itoh, S Kauffman, S Lloyd, S Odenbach, S Sun, S Taketomi, S Traverso, SA Newman, T Schroeder, V Fritsch, V Hoffmann, VK Mer La, VM Goldschmidt, VN Manoharan, VTh Marteinsson, VV Korolev, W Cruz da, W Martin, W Martin, WH Zurek, Y Kwon, Y Lalatonne, Y Min, Z Merali, Z Sawlowicz, Z Sawlowicz, Z Wang   +172 more
core   +1 more source

Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways

BMC Cancer, 2018
Background Cancer cells require increased levels of nutrients such as amino acids to sustain their rapid growth. In particular, leucine and glutamine have been shown to be important for growth and proliferation of some breast cancers, and therefore ...
Michelle van Geldermalsen, Lake-Ee Quek, Nigel Turner, Natasha Freidman, Angel Pang, Yi Fang Guan, James R. Krycer, Renae Ryan, Qian Wang, Jeff Holst   +9 more
doaj   +1 more source

Prospective Cohort Study of Emergency Department Visit Frequency and Diagnoses Before and During COVID-19 Pandemic in Urban, Low-Income, US- and Foreign-Born Mothers in Boston, MA

Western Journal of Emergency Medicine, 2023
Background: The coronavirus 2019 (COVID-19) pandemic fundamentally changed how populations interface with the healthcare system. Despite historical spikes in US mortality during the pandemic, emergency department (ED) visits were paradoxically low.
Valerie Osula, Serena Rusk, Lingxin Hao, Bhakti Hansoti, Alison Gemmill, Xiumei Hong, Guoying Wang, Colleen Pearson, William G. Adams, Xiaobin Wang   +9 more
doaj   +1 more source

Growth, current size and the role of the 'reversal paradox' in the foetal origins of adult disease: an illustration using vector geometry [PDF]

, 2006
BACKGROUND Numerous studies have reported inverse associations between birth weight and a range of diseases in later life. These have led to the development of the 'foetal origins of adult disease hypothesis'. However, many such studies have only been
Ellison, G.T.H., Gilthorpe, M.S., Tu, Y-K.   +2 more
core   +3 more sources

Evidence of Late Miocene Peri-Tibetan Aridification From the Oldest Asian Species of Sandgrouse (Aves: Pteroclidae)

Frontiers in Ecology and Evolution, 2020
The partial skeleton of a new extinct taxon, Linxiavis inaquosus, from the Liushu Formation (6–9 Ma) at the edge of the Tibetan Plateau in Gansu Province, China is the most substantial known fossil record of sandgrouse (Pteroclidae).
Zhiheng Li, Zhiheng Li, Thomas A. Stidham, Thomas A. Stidham, Thomas A. Stidham, Tao Deng, Tao Deng, Zhonghe Zhou, Zhonghe Zhou   +8 more
doaj   +1 more source

Prebiotic Synthesis of Aspartate Using Life’s Metabolism as a Guide

Life, 2023
A protometabolic approach to the origins of life assumes that the conserved biochemistry of metabolism has direct continuity with prebiotic chemistry. One of the most important amino acids in modern biology is aspartic acid, serving as a nodal metabolite
Stuart A. Harrison, William L. Webb, Hanadi Rammu, Nick Lane   +3 more
doaj   +1 more source