Results 41 to 50 of about 10,116 (169)

Efficacy and safety of orlistat in male patients with overweight/obesity and hyperuricemia: results of a randomized, double-blind, placebo-controlled trial

Lipids in Health and Disease
Background Obesity is associated with elevated serum uric acid (SUA) levels and frequent gout flares. Losing weight can reduce the SUA level and gout flares.
Shuang Liu, Xiaojing Lin, Minghao Tao, Qi Chen, Hang Sun, Yali Han, Shaoling Yang, Yining Gao, Shen Qu, Haibing Chen   +9 more
doaj   +1 more source

Investigating the Hepatic Response to Orlistat and White Tea in Rats on a High-Fat Diet

Life
High-fat diets have detrimental health impacts that increase the likelihood of developing obesity and metabolic syndrome. This study aimed to examine the potential antioxidant and anti-inflammatory effects of orlistat and white tea in rats fed a high-fat
Serpil Ciftel, Aleksandra Klisic, Enver Ciftel, Tolga Mercantepe, Adnan Yilmaz, Sedat Ciftel, Esra Pinarbas, Merve Nur Toraman, Filiz Mercantepe   +8 more
doaj   +1 more source

Inhibition of fatty acid metabolism reduces human myeloma cells proliferation. [PDF]

PLoS ONE, 2012
Multiple myeloma is a haematological malignancy characterized by the clonal proliferation of plasma cells. It has been proposed that targeting cancer cell metabolism would provide a new selective anticancer therapeutic strategy.
José Manuel Tirado-Vélez, Insaf Joumady, Ana Sáez-Benito, Irene Cózar-Castellano, Germán Perdomo   +4 more
doaj   +1 more source

Prevalence and Factors Associated With Symptom Profiles of Disorders of Gut‐Brain Interaction in Obesity Before and After Treatment

Neurogastroenterology &Motility, EarlyView.
DGBI symptoms are common in obesity and have the potential to exacerbate negative health outcomes. In general, the prevalence of DGBI symptoms decreases after obesity treatment, but patients can also shift from one GI symptom profile to another. ABSTRACT Background & Aims Disorders of gut‐brain interaction (DGBI) in obesity could impair health outcomes.
Esther Colomier, Janita Halminen, Malin Björck, Gudrún Höskuldsdóttir, Karin Mossberg, My Engström, Björn Eliasson, Ville Wallenius, Lars Fändriks, Jan Tack, Hans Törnblom, Magnus Simrén   +11 more
wiley   +1 more source

Inflammatory Bowel Disease in Children and Young People Living With Overweight or Obesity: A Critical Narrative Review

Obesity Reviews, EarlyView.
ABSTRACT Inflammatory bowel disease is a chronic inflammatory disorder affecting the gastrointestinal tract. It mainly comprises of Crohn's disease and ulcerative colitis. Its global prevalence has risen simultaneously with overweight and obesity among children and young people over the last decades.
Razan Algarni, Efstathia Papada, Adrian Brown   +2 more
wiley   +1 more source

Beneficial effects of training at the anaerobic threshold in addition to pharmacotherapy on weight loss, body composition, and exercise performance in women with obesity

Patient Preference and Adherence, 2015
Oguz Ozcelik,1 Yusuf Ozkan,2 Sermin Algul,1 Ramis Colak2,3 1Department of Physiology, 2Department of Endocrinology and Metabolic Disease, Faculty of Medicine, Firat University, Elazig, 3Department of Endocrinology and Metabolic Disease, Faculty of ...
Ozcelik O, Ozkan Y, Algul S, Colak R
doaj  

Orlistat facilitates immunotherapy via AKT-FOXO3a-FOXM1-mediated PD-L1 suppression

Journal for ImmunoTherapy of Cancer
Background The immunotherapy targeting cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death ligand-1 (PD-L1) has achieved significant breakthroughs, but further improvements are still needed in cancer treatment.Methods We ...
Jie Li, Shiming Yang, Liting Wang, Xiaoyan Zhao, Changjiang Hu, Qingyun Tang, Lianhua Zhang, Shuo Zeng, Qiyu Bao, Weichao Hu, Lijiao He, Guiping Huang, Yunyi Liu   +12 more
doaj   +1 more source

Orlistat after initial dietary/behavioural treatment: changes in body weight and dietary maintenance in subjects with sleep related breathing disorders

Nutrition Journal, 2011
Background Sleep related breathing disorders (SRBD) are associated with increased morbidity and mortality and weight loss is recommended to overweight or obese patients with SRBD. However, maintenance of weight loss is difficult to achieve and strategies
Tonstad Serena, Svendsen Mette
doaj   +1 more source

Multidisciplinary Therapy to Target Obesity and Its Complications in Adult Population: A Narrative Review

Obesity Reviews, EarlyView.
ABSTRACT Obesity as a chronic and multifactorial disease requires a multidisciplinary team acting together in a holistic multitarget intervention. Multidisciplinary therapy targeting obesity and its complications includes physical exercise, nutritional, and behavior counseling.
Ana Raimunda Dâmaso, Flávia Campos Corgosinho, Deborah Cristina Landi Masquio, Nayra Figueiredo, Fabiana Kattah, Cintia Cercato, Lian Tock, Raquel Munhoz da Silveira Campos   +7 more
wiley   +1 more source

Integrated fecal microbiota and metabolomics analysis of the orlistat intervention effect on polycystic ovary syndrome rats induced by letrozole combined with a high-fat diet

Journal of Ovarian Research, 2023
Background This study aimed to compare the characteristics of the gut microbiota and their metabolite profiles between polycystic ovary syndrome (PCOS) and orlistat-treated PCOS rats (ORL-PCOS), which could help to better understand the underlying ...
Jianmei Yang, Enli Wang, Mingmin Jiang, Yujun Tan, Fangfang Yao, Chenghong Sun, Lihong Pan, Ling Gao, Jingchun Yao   +8 more
doaj   +1 more source