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Validated analytical workflow for quantifying proline metabolism related amino acids in HaCaT cells with LC-Q-TOF-MS. [PDF]
Sci RepPlewa S +5 more
europepmc +1 more source
Pflügers Archiv - European Journal of Physiology, 2000 The fate of ornithine in the nephron of the female OF-1 Swiss mouse remains unknown. The aim of the present study was to identify the nephron segments containing the key enzymes involved in ornithine metabolism: ornithine decarboxylase (ODC) and ornithine aminotransferase (OAT).
Levillain, O. +3 more
core +6 more sources
Biochimica Et Biophysica Acta - General Subjects, 1986 Ornithine decarboxylase was present in a cryptic, complexed form in an amount approximately equivalent to that of free ornithine decarboxylase activity in adult rat heart.
Claudio Stefanelli +2 more
exaly +2 more sources
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Ornithine phenylacetate revisited
Metabolic Brain Disease, 2013In patients with liver failure hyperammonemia is associated with the development of hepatic encephalopathy (HE) and immune impairment. Treatment of hyperammonemia is an unmet clinical need. Ornithine phenylacetate (OP) is a novel drug that is targeted at reducing ammonia concentration in patients with liver disease and therefore a potential treatment ...
Maria, Jover-Cobos +3 more
openaire +2 more sources
Ornithine aminotransferase of fishes
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1973Abstract 1. 1. The activity of ornithine aminotransferase was measured in liver and other tissues from a number of species of fish. 2. 2. Significant levels of the enzymes were detected in many of the species investigated. 3. 3. The fish enzyme appears to be similar to the enzyme found in higher animals. 4. 4.
M M, Wekell, G W, Brown
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Crystalline ornithine transcarbamylase
Biochimica et Biophysica Acta (BBA) - Enzymology, 1967Abstract Ornithine transcarbamylase (carbamoyl phosphate: l -ornithine carbamoyl transferase, EC 2.1.2.2) from arginine grown Streptococcus D10 cells was purified to homogeneity by acid, solvent, heat, and salt fractionation. The enzyme was then crystallized from an ammonium sulfate solution. Some molecular properties of the enzyme are described.
S H, Bishop, S, Grisolia
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Ornithine decarboxylase and ornithine decarboxylase‐inhibiting activity in rat thymocytes
Cell Biochemistry and Function, 1992AbstractIsolation of thymocytes from rat thymus resulted in the disappearance of the high activity of ornithine decarboxylase (ODC) that characterizes the thymus of young rats, together with the appearance of an antizyme‐like ODC inhibiting activity, which showed a chromatographic profile that resembled that of dexamethasone‐treated rat thymus ...
C, Stefanelli +4 more
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Separation of Ornithine and Lysine Activities of the Ornithine-Transcarbamylase-Catalyzed Reaction
Enzyme, 2017Several lines of evidence are presented that an entity is present in mitochondria which converts lysine and carbamylphosphate to homocitrulline, distinct from the ornithine transcarbamylase (OTC): lack of inhibition by lysine of OTC with ornithine as substrate at the pH of the mitochondrial matrix, a K(m) for lysine of 6.3 mmol/l in the crude ...
F A, Hommes +3 more
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Ornithine aminotransferase activity, tissue ornithine concentrations and polyamine metabolism
International Journal of Biochemistry, 19891. Inactivation of L-ornithine:2-oxoacid aminotransferase (OAT) by 5-fluoromethylornithine (5FMOrn), a specific inactivator of OAT, causes a great elevation of tissue ornithine (Orn) concentrations. 2. Inhibition of L-ornithine decarboxylase (ODC) by 2-difluoromethylornithine (DFMO) had no effect on Orn concentrations. 3. The combined administration of
N, Seiler +3 more
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