Results 71 to 80 of about 35,273 (228)

LUCID: An Integrative Approach for Target Discovery and dsRNA Design in Plant Fungal Pathogens

Plant Biotechnology Journal, EarlyView.
LUCID: A computational pipeline for RNAi‐based biofungicide design. ABSTRACT Phytopathogenic fungi pose an escalating threat to global food security and ecosystem stability, as resistance and environmental concerns diminish the effectiveness of conventional fungicides.
Lucía Jiménez‐Castro, Alba López‐Laguna, Dolores Férnandez‐Ortuño, Alejandro Pérez‐García, Álvaro Polonio   +4 more
wiley   +1 more source

Orotic Aciduria [PDF]

, 2018
Orotic acid is an intermediate found in the pathway for pyrimidine synthesis. The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes the production of orotic acid by the conversion of the compound dihydroorotate to orotic acid.
Fonteh, Aliah L
core   +1 more source

Endosymbiosis in trypanosomatids: the genomic cooperation between bacterium and host in the synthesis of essential amino acids is heavily influenced by multiple horizontal gene transfers [PDF]

, 2013
Background Trypanosomatids of the genera Angomonas and Strigomonas live in a mutualistic association characterized by extensive metabolic cooperation with obligate endosymbiotic Betaproteobacteria.
Alves, João M.P., Buck, Gregory A., Camargo, Erney P., Costa-Martins, André G., da Silva, Flávia Maia, Klein, Cecilia C., Motta, Maria Cristina M., Sagot, Marie-France, Serrano, Myrna G., Teixeira, Marta M.G., Vasconcelos, Ana Tereza R.   +10 more
core   +5 more sources

Pharmacological Approaches to Antitrypanosomal Chemotherapy

Memorias do Instituto Oswaldo Cruz, 1999
There is an urgent need for new drugs for the chemotherapy of human African trypanosomiasis, Chagas disease and leishmaniasis. Progress has been made in the identification and characterization of novel drug targets for rational chemotherapy and ...
Simon L Croft
doaj   +1 more source

ALOX15‐Derived Oxylipins Attenuate Macrophage Inflammatory Signaling Via a Gαq–PLC–PKC Pathway

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
ALOX15 expression and its downstream oxylipins, including 12‐HETE and 13‐HODE, are induced in intestinal epithelial and lamina propria immune cells during the early and middle phases of experimental colitis. These endogenous lipid mediators suppress lipopolysaccharide‐induced TNF‐α and IL‐6 production in macrophages without affecting cell viability ...
Adrian Hilman, Yoshiki Ishii, Bambang Dwi Wijatniko, Dina Mustika Rini, Takuya Suzuki   +4 more
wiley   +1 more source

Does hyperprolactinemia affect hepatic regeneration independent of sex steroids? [PDF]

, 1988
Prolactin, administered exogeneously, has been shown to be trophic to the liver, causing increases in the liver weight-to-body weight ratio, in ornithine decarboxylase activity, and in thymidine kinase activity.
Casavilla, A, Chapchap, P, Eagon, PK, Gavaler, JS, Kahn, D, Makowka, L, Mazzaferro, V, Porter, L, Smith, MS, Starzl, TE, Van Thiel, DH   +10 more
core  

Effects of Amino Acid Decarboxylase Genes and pH on the Amine Formation of Enteric Bacteria From Chinese Traditional Fermented Fish (Suan Yu)

Frontiers in Microbiology, 2020
The formation of biogenic amines (BAs) is an important potential risk in Suan yu. This study investigated the amine production abilities of 97 strains of enteric bacteria screened from Suan yu.
Qin Yang, Qin Yang, Qin Yang, Ju Meng, Ju Meng, Ju Meng, Wei Zhang, Lu Liu, Lu Liu, Lu Liu, Laping He, Laping He, Laping He, Li Deng, Li Deng, Li Deng, Xuefeng Zeng, Xuefeng Zeng, Xuefeng Zeng, Chun Ye, Chun Ye, Chun Ye   +21 more
doaj   +1 more source

A Pathway‐Based Metabolomics Approach Reveals Metabolic Strategies and Reprogramming in Drought‐Tolerant Soybean Genotypes

Legume Science, Volume 8, Issue 1, March 2026.
ABSTRACT Soybean (Glycine max) is a globally important crop, yet its productivity is highly susceptible to drought stress, particularly in rainfed systems. To better understand the biochemical basis of drought tolerance, this study employed pathway‐based metabolomics to characterize differentially expressed metabolites between drought‐tolerant and ...
Namhee Lee, Donna K. Harris, Zenglu Li, Joon Hyuk Suh   +3 more
wiley   +1 more source

Effect of an antiandrogenic H2 receptor antagonist on hepatic regeneration in rats [PDF]

, 1988
Because biochemical 'feminization' of the liver in males is observed with hepatic regeneration and because the hepatic regenerative response in females is greater than that in males, the posibility that antiandrogens might potentiate liver regeneration ...
Chapchap, P, Eagon, PK, Kahn, D, Makowka, L, Podesta, L, Starzl, TE, Svanas, GW, Van Thiel, DH   +7 more
core  

ODC1 Polyamine Metabolism Drives Prostate Cancer via AKT and Splicing

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Prostate cancer is an aggressive disease with limited quantifiable biomarkers. One gene of interest is ODC1, which encodes ornithine decarboxylase, the rate‐limiting enzyme converting ornithine to putrescine in polyamine metabolism. Although ODC1 is known to be involved in prostate cancer development, exactly how it drives the disease ...
Jian Ma, Ting Pan, Shengli Sun, Musitapa Mutalifu, Wei Yang, Yue Niu, Peng Chen   +6 more
wiley   +1 more source