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Dual Urea Cycle Dysfunction Caused by Coexisting Argininosuccinic Aciduria and Citrin Deficiency: Clinical, Biochemical, and Molecular Insights From an Exceptional Case. [PDF]
JIMD RepABSTRACT Dual inherited defects affecting urea cycle function are exceptionally rare. We report the first case, to our knowledge, of the coexistence of argininosuccinic aciduria (ASA) and citrin deficiency (CD). A girl born to consanguineous Tunisian parents presented at 6 months of age with recurrent seizures, vomiting, developmental delay, and severe
Zribi M +6 more
europepmc +2 more sources
The role of orotic acid in pyrimidine biosynthesis in Neurospora. [PDF]
, 1966 The role of orotic acid in pyrimidine biosynthesis in ...
R. L. Hermann, Hermann, R. L.
core +1 more source
Journal of Lipid Research, 1985 Dietary orotic acid is known to cause impaired fatty acid synthesis and increased cholesterol synthesis in rats. We found that the impaired fatty acid synthesis occurs during the first day of orotic acid feeding and, in studies with albumin-bound [1-14C ...
S D Tokmakjian, D S Haines
doaj +1 more source
Effect of Camel's Milk Processing on Orotic Acid Stability [PDF]
Journal of Food and Dairy SciencesThe objective of this study was to evaluate orotic acid stability throughout the manufacture and storage of camel milk products. The results observed that, freezing camel milk for 3 months at -18°C led to stability of orotic acid, pH and acidity did not ...
E. M. Abdeen
doaj +1 more source
Integrated Multi-Omics Analysis for Inferring Molecular Players in Inclusion Body Myositis
Antioxidants, 2023 Inclusion body myositis (IBM) is an acquired inflammatory myopathy affecting proximal and distal muscles that leads to weakness in patients over 50.
Judith Cantó-Santos +15 more
doaj +1 more source
Clinical Pathology, 2022 Objective: Hyperargininemia due to Arginase 1 deficiency is a rare inborn error of the urea cycle with an incidence estimated at 1:950 000. It has typical severe and progressive abnormal neurological features with biochemical findings of hyperargininemia
Anasufiza Habib +1 more
doaj +1 more source
Journal of Lipid Research, 1972 The levels of hepatic neutral lipids in the orotic acid-fed rat were inversely related to the dietary levels of polyunsaturated fatty acids, as in the choline-deficient rat.
L.A. Witting
doaj +1 more source
Development of an assay to simultaneously measure orotic acid, amino acids, and acylcarnitines in dried blood spots. [PDF]
Clin Chim Acta, 2014 Held PK +3 more
europepmc +2 more sources
Serum lipoprotein accumulation in the livers of orotic acid-fed rats
Journal of Lipid Research, 1971 This study provides confirmation of previous observations that showed that rats fed a diet containing 1% orotic acid for 7 days develop a fatty liver and that there is an inhibition of the secretion of low density lipoproteins without altering general ...
LAWRENCE A. POTTENGER, GODFREY S. GETZ
doaj +1 more source
Ghrelin and orotic acid increased in subclinical mastitis
, 2008 Hormone ghrelin and orotic acid accelerate wound healing as well as controlling inflammation and immunity. We have, therefore, investigated the serum and milk levels of ghrelin and orotic acid in dairy cows with (n = 21) or without (n = 21) subclinical ...
Karataş, Fikret +5 more
core +2 more sources