Results 41 to 50 of about 2,711,207 (206)

System‐Local Axes and Metabolic Reprogramming From Health to Response in House Dust Mite‐Specific Subcutaneous Immunotherapy for Allergic Rhinitis

iMetaMed, EarlyView.
This study delineated nasal‐plasma metabolic reprogramming in house dust mite‐allergic rhinitis (HDM‐AR) and subcutaneous immunotherapy (SCIT) response, showing compartment‐specific signatures dominated by nasal lipid‐redox and plasma nucleotide‐NAD+ axes and across the HC–HDM‐AR–SCIT response continuum, dual‑compartment metabolites exhibited ...
Bixing Fang, Fei Pan, Yachun Li, Yimeng Wang, Ze Wang, Zhiheng Huang, Ming Chen, Yun Li, Mengli Huang, Cheng Guo, Chubo Xie, Lina Dong, Yadong Gao, Zhuohang Yu   +13 more
wiley   +1 more source

Studies relevant to the biosynthesis of orotic acid. [PDF]

, 2018
The biosynthesis of orotic acid is briefly reviewed. This investigation is concerned with elucidating the stereo-chemical requirements of dihydro-orotic dehydrogenases the enzyme involved in the final stage of the biosynthesiss, with respect to the ...
Atkinson, Michael.
core  

Hepatocyte‐Centered Regulation of MASH Fibrosis: From Animal Models to Molecular Mechanisms and Targeted Therapies

iNew Medicine, EarlyView.
This review highlights hepatocytes as active regulators of MASH fibrosis through secreted proteins, metabolites, and extracellular vesicles that modulate hepatic stellate cell activation. These hepatocyte–stellate cell communication pathways provide a mechanistic framework for developing targeted antifibrotic therapies, including hepatocyte‐directed ...
Eui Jung Jung, Xiaobo Wang
wiley   +1 more source

Orotic Acid in Yoghurt

Journal of Dairy Science, 1969
Abstract During the preparation of commercial yoghurt from milk, the mean concentration of orotic acid decreased from 8.2 to 4.6 mg/100ml. This decrease was attributed to the metabolic activity of the Lactobacillus species used in preparation of the yoghurt.
P. Okonkwo, J.E. Kinsella
openaire   +1 more source

DataSheet1_Hereditary orotic aciduria identified by newborn screening.docx

, 2023
Introduction: Hereditary orotic aciduria is an extremely rare, autosomal recessive disease caused by deficiency of uridine monophosphate synthase.
Elena Dumin (14786797), Nava Shaul Lotan (14786812), Stanley H. Korman (14786824), Suha Daas (14786791), Ronen Spiegel (3993077), Rachel Rock (13826170), Talya Saraf-Levy (14786809), Igor Ulanovsky (14786818), Ortal Barel (6526067), Tzipora C. Falik-Zaccai (9526539), Yuval Landau (5700371), Galit Tal (14786815), Shlomo Almashanu (6987575), Eli Hershkovitz (15254), Aviva Fattal-Valevski (6018473), Tally Lerman-Sagie (14786803), Hanna Mandel (190906), Yael Wilnai (14786821), Yair Anikster (349974), Nira Rostami (14786806), Nadirah S. Damseh (14786788), Sagi Josefsberg (14786800), Orna Staretz-Chacham (3131892), Nasser Abu Salah (14786794)   +23 more
core   +1 more source

Diaqua(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-3-ide-4-carboxylato-κ2N3,O4)(1,10-phenanthroline-κ2N,N′)manganese(II)

Acta Crystallographica Section E, 2008
The title compound, [Mn(C5H2N2O4)(C12H8N2)(H2O)2], was synthesized by the reaction of manganese(II) acetate and orotic acid in the presence of 1,10-phenanthroline.
Zebao Zheng, Jikun Li, Yanmin Huo, Rentao Wu   +3 more
doaj   +1 more source

Changes of Microbial and Component Composition of Giraffe Milk During Mid‐ to Late Lactation

Zoo Biology, EarlyView.
Giraffe milk – graphical abstract text, Giraffe: late lactation milk, Involution at approximately 15 months of lactation, Content of saccharides and fat decrease, Protein content increases, Content of minerals increase, Microbiological quality high ABSTRACT The proximate, mineral and microbiological composition of milk from five giraffes from mid ...
G. Osthoff, C. J Hugo, S Van der Merwe, A Hugo, F Deacon   +4 more
wiley   +1 more source

A neonate with ornithine aminotransferase deficiency; insights on the hyperammonemia-associated biochemical phenotype of gyrate atrophy

Molecular Genetics and Metabolism Reports, 2022
Gyrate atrophy of the choroid and retina (GACR) secondary to deficiency of ornithine aminotransferase (OAT) is a rare autosomal recessive metabolic disorder usually diagnosed in childhood when patients develop myopia and a characteristic retinal ...
Aneta Kaczmarczyk, Mark Baker, Julianna Diddle, Tatiana Yuzyuk, David Valle, Kristin Lindstrom   +5 more
doaj   +1 more source

DIETARY ADENINE ALLEVIATES FATTY LIVER INDUCED BY OROTIC ACID

Indonesian Journal of Chemistry, 2010
The effects of dietary adenine in fatty liver induced by orotic acid (OA) were studied. Rats were paired-fed 1% OA-supplemented diets with/or without 0.25% adenine or a diet without OA for 10 days.
Yohanes Buang
doaj   +1 more source

Novel Amino Acid Changes Increase Phosphoenolpyruvate Carboxylase Output in planta

Plant, Cell &Environment, Volume 49, Issue 11, Page 8306-8321, November 2026.
ABSTRACT Characterization of previously reported Arabidopsis mutants with increased aluminum (Al) resistance (alr) resulting from greater release of Al‐chelating malate identified three unique amino acid substitutions that each impacts PHOSPHOENOLPYRUVATE CARBOXYLASE 1, a key anaplerotic carbon fixation enzyme.
Jinrui Sheng, Kevin Frausto, Sarah Haesaerts, Taylor J. Meyer, Maruša Prolič‐Kalinšek, Seán E. O'Leary, Remy Loris, Paul B. Larsen   +7 more
wiley   +1 more source