Results 51 to 60 of about 2,711,207 (206)

MAGNESIUM-CONTAINING DRUGS IN CARDIOVASCULAR DISEASES

Рациональная фармакотерапия в кардиологии, 2015
At present experimental and clinical data confirming efficacy of magnesium-containing drugs in different cardiovascular diseases are obtained. Physiological significance of magnesium is determined by its intracellular fraction.
A. V. Govorin, A. P. Filev
doaj   +3 more sources

Apolipoproteins of the orotic acid fatty liver: implications for the biogenesis of plasma lipoproteins.

Journal of Lipid Research, 1988
Rats fed orotic acid develop fatty livers characterized by triglyceride-laden, membrane-bounded vesicles designated ''liposomes.'' We have measured the levels of apolipoproteins in isolated liposomes and other subcellular fractions by SDS-polyacrylamide ...
R Hay, R Fleming, W O'Connell, J Kirschner, W Oppliger   +4 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, Volume 16, Issue 10, Page 1911-1924, October 2026.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Nascent high density lipoproteins from liver perfusates of orotic acid-fed rats.

Journal of Lipid Research, 1990
Uniformly fatty livers from orotic acid-fed rats secreted almost no very low density lipoproteins (VLDL) but normal amounts of nascent high density lipoproteins (HDL) accumulated in perfusates.
R L Hamilton, L S Guo, T E Felker, Y S Chao, R J Havel   +4 more
doaj   +1 more source

Liver metabolic perturbations of heat-stressed lactating dairy cows [PDF]

Asian-Australasian Journal of Animal Sciences, 2018
Objective The objective of the present study was to elucidate the mechanism underlying liver metabolic perturbations in dairy cows exposed to heat stress (HS).
Caiyun Fan, Di Su, He Tian, Xiaojiao Li, Yu Li, Lei Ran, Ruiting Hu, Jianbo Cheng   +7 more
doaj   +1 more source

Phenotype‐guided etiologic workup in a prospective cohort of 144 adults with developmental and epileptic encephalopathy

Epilepsia Open, Volume 11, Issue 5, Page 1635-1650, October 2026.
Abstract Objectives Adults with developmental and epileptic encephalopathies (DEEs) often enter adult neurology care without etiologic clarification because of incomplete transition from pediatric services, outdated investigations, and attenuation of childhood electro‐clinical features over time.
Giuseppe d’Orsi, Umberto Costantino, Maria Teresa Di Claudio, Carmela Pia Ferro, Pietro Palumbo, Mario Benvenuto, Massimiliano Copetti, Leonardo D'Agruma, Massimo Carella, Marco Castori, Orazio Palumbo   +10 more
wiley   +1 more source

Stable isotope dilution analysis of orotic acid and uracil in amniotic fluid [PDF]

, 1984
Rapid, sensitive and accurate stable isotope dilution assays were developed for the measurement of orotic acid and uracil in amniotic fluid. The method utilizes [15N2]orotic acid and [15N2]uracil as internal standards, isolation by liquid partition ...
Gruenke, L., Jakobs, C., Nyhan, W.L., Craig, J.C., Sweetman, L., Wadman, S.K.   +5 more
core  

An Optimized Diagnostic Approach for Adults With Suspected Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
A multidisciplinary strategy that integrates deep phenotyping with expert genetic interpretation substantially increases the likelihood of reaching a diagnosis in adults suspected of having an IMD. ABSTRACT Inherited metabolic disorders (IMDs) arise from defects in metabolic pathways essential for normal biochemical function.
Machteld M. Oud, Elise A. Ferreira, Clara D. M. van Karnebeek, Robin Wijngaard, Nicole I. Wolf, Marc Engelen, Mareen Datema, Sacha Ferdinandusse, André B. P. van Kuilenburg, Laura Steinbusch, Saskia N. van der Crabben, Mirjam Langeveld, on behalf of the ZOEMBA Study Group   +12 more
wiley   +1 more source

Orotic acid salts as sources of orotic acid and various minerals added for nutritional purposes to food supplements

, 2009
The petitioners have submitted only few data concerning the toxicity of orotic acid and none on the salts. Orotic acid has a low acute toxicity. In repeated doses orotic acid induces fatty livers in the rat, but not in other species tested.
J. Gilbert, P. Tobback, T. Verguieva, D. M. Gott, A. Mortensen, I. Pratt, B. Dusemund, F. Aguilar, J. C. Leblanc, GRILLI, SANDRO, R. A. Woutersen, I. Stankovic, C. Lambré, D. Parent Massin, I. M. C. M. Rietjens, G. E. N. Kass, R. Gürtler, J. König, J. C. Larsen, U. R. Charrondiere, P. Galtier   +20 more
core   +1 more source

Safety of magnesium orotate dihydrate as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of magnesium from this source in the context of Directive 2002/46/EC

EFSA Journal
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of magnesium orotate dihydrate as a novel food (NF) pursuant to Regulation (EU) 2015/2283 ...
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, María de la Montaña Cámara Hurtado, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige Mcnulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Francesco Cubadda, Thomas Frenzel, Ursula Gundert‐Remy, Francesca Marcon, Miguel Prieto Maradona, Monika Neuhäuser‐Berthold, Alexandros Siskos, Matt Wright, Leonard Matijević, Harry McArdle   +24 more
doaj   +1 more source