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Orphan nuclear receptors in T lymphocyte development
Journal of Leukocyte Biology, 2002AbstractLymphocyte development is initiated from hematopoietic stem cells and can be divided into multiple phenotypically distinct stages. Transcription factors play important roles in programming the developmental process of lymphocytes. Recent studies have identified key roles of several orphan nuclear receptors in T lymphocyte development.
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Orphan Nuclear Receptor Promotes Retinoid Signals
Science's STKE, 2000Retinoids have multiple biological effects, including inhibition of proliferation of certain cancer cells. The retinoids often act through heterodimers of two nuclear receptors, retinoic acid receptors (RARs) and the retinoid X receptors (RXRs).
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Orphan Nuclear Receptors, Excellent Targets of Drug Discovery
Combinatorial Chemistry & High Throughput Screening, 2006To date, the pharmaceutical industry has placed a considerable amount of interest in the discovery of drug targets and diagnostics. One of the most challenging areas of drug discovery today is the search for novel receptor-ligand pairs. Nuclear receptors comprise a large superfamily of ligand-dependent transcription factors that regulate the expression
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The orphan nuclear receptors in cancer and diabetes
Journal of Receptors and Signal Transduction, 2013The orphan nuclear receptors (ONRs) are a vital class of transcriptional regulators belonging to the larger nuclear receptors (NRs) superfamily in higher eukaryotes. As a result of non-identification of endogenous physiological ligands for this class of NRs, they are designated as "orphans".
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[Pharmacological importance of orphan nuclear receptors].
Ceskoslovenska fysiologie, 2015The orphan nuclear receptors belong to the family of ligand-activated transcription factors localized in the nucleus or cytoplasm. Through them, many biological processes such as metabolism of glucose, lipids and bile acids, inflammation, tumour growth, or differentiation of cells, are controlled.
M, Sima, O, Slanar
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Orphan Nuclear Receptors and Their Ligands
1998Nuclear hormone receptors constitute a superfamily of related transcription factors that mediate the actions of nuclear-acting hormones including glucocorticoids, mineralocorticoids, estrogens, progestins, androgens, thyroid hormones, vitamin D, and retinoic acid (Mangelsdorf and Evans 1995).
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