Results 111 to 120 of about 13,277 (283)

Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics

Advanced Healthcare Materials, Volume 14, Issue 14, May 28, 2025.
This study investigates the potential of nanohybridized niclosamide as a therapeutic agent for Mpox, focusing on enhanced bioavailability, improved antiviral efficacy, and controlled drug release achieved through nanoengineering. The research emphasizes significant advancements in formulation strategies, mechanistic insights, and therapeutic outcomes ...
N. Sanoj Rejinold, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication. [PDF]

, 2013
Myxoma virus (MYXV)-encoded protein M029 is a member of the poxvirus E3 family of dsRNA-binding proteins that antagonize the cellular interferon signaling pathways.
Chan, Winnie M, Liu, Jia, McFadden, Grant, Rahman, Masmudur M, Rothenburg, Stefan   +4 more
core   +1 more source

Recombinant Orthopoxvirus Primes Colon Cancer for Checkpoint Inhibitor and Cross-Primes T Cells for Antitumor and Antiviral Immunity

Molecular Cancer Therapeutics, 2020
Although it is known that oncolytic viruses can inflame and recruit immune cells to otherwise immunosuppressed tumor microenvironments, the influence of the antiviral immune response on antitumor immunity is less clear across viral platforms and tumor ...
Sang-In Kim, Anthony K. Park, S. Chaurasiya, Seonah Kang, Jianming Lu, A. Yang, Venkatesh Sivanandam, Zhifang Zhang, Y. Woo, S. Priceman, Y. Fong, S. Warner   +11 more
semanticscholar   +1 more source

Orthopoxvirus species and strain differences in cell entry

Virology, 2012
Vaccinia virus (VACV) enters cells by a low pH endosomal route or by direct fusion with the plasma membrane. We previously found differences in entry properties of several VACV strains: entry of WR was enhanced by low pH, reduced by bafilomycin A1 and relatively unaffected by heparin, whereas entry of IHD-J, Copenhagen and Elstree were oppositely ...
Zain Bengali, P. S. Satheshkumar, Bernard Moss   +2 more
openaire   +3 more sources

Identification of Novel Cetacean Poxviruses in Cetaceans Stranded in South West England [PDF]

, 2015
Poxvirus infections in marine mammals have been mainly reported through their clinical lesions and electron microscopy (EM). Poxvirus particles in association with such lesions have been demonstrated by EM and were previously classified as two new ...
Barnett, J, Dastjerdi, A, Davison, N, Deaville, R, Everest, D, Finnegan, C, Jepson, P, Peake, J, Steinbach, F   +8 more
core  

Sporotrichosis caused by sporothrix mexicana, Portugal [PDF]

, 2011
Sporotrichosis is a subcutaneous fungal infection present worldwide that is caused by traumatic inoculation or inhalation of spores of the dimorphic fungus Sporothrix schenckii complex (1-3). However, molecular studies have shown that the S.
Dias, Nicolina, Lima, Nelson, Oliveira, M. M. E., Portela, M., Santos, C., Zancope-Oliveira, R. M.   +5 more
core   +3 more sources

New chemical agents based on adamantane-monoterpene conjugates against orthopoxvirus infections.

RSC Medicinal Chemistry, 2020
Currently, the spectrum of agents against orthopoxviruses, in particular smallpox, is very narrow. Despite the fact that smallpox is well controlled, there is, for many reasons, a real threat of epidemics associated with this or a similar virus. In order
E. Suslov, Evgenii S Mozhaytsev, D. Korchagina, N. I. Bormotov, O. Yarovaya, K. Volcho, O. Serova, A. Agafonov, R. Maksyutov, L. Shishkina, N. Salakhutdinov   +10 more
semanticscholar   +1 more source

Viral metagenomic analysis reveals potential biological hazards in non‐human primates in a zoo

Animal Research and One Health, Volume 3, Issue 2, Page 217-228, May 2025.
The investigation identifies the presence of Encephalomyocarditis virus (EMCV), Baboon endogenous virus (BAV), Human endogenous retrovirus (HERV), and Baboon endogenous virus (BaEV) in non‐human primates (NHPs) at the Zoo, indicating potential zoonotic threats.
Ruiying Liang, Xinming Tang, Lin Liang, Jiabo Ding, Ye Tian, Yixian Qin, Sufen Zhao, Lixia Zhang, Tianchun Pu, Xuefeng Liu, Jinpeng Liu, Chenglin Zhang, Zibin Li, Ting Jia   +13 more
wiley   +1 more source

Insights into poxviruses: virology and vaccines

Acta Virologica
Due to the successful eradication of smallpox worldwide and the cessation of smallpox vaccination campaign in 1980, the human population seems to be more susceptible to poxvirus infection.
Adriana Manuka, Irsida Mehmeti, Antonia Radaelli, Eduart Hashorva, Carlo Zanotto, Carlo De Giuli Morghen   +5 more
doaj   +1 more source

Orthopoxvirus Infections: Epidemiology, Clinical Picture, and Diagnostics (Scientific Review)

Проблемы особо опасных инфекций, 2013
Lack of immunity among the population against pathogenic orthopoxviruses and an increased number of these infections human cases testify to the need of development of the rapid high-sensitive methods for species-specific orthopoxvirus diagnostics.
E. V. Gavrilova, R. A. Maksyutov, S. N. Shchelkunov   +2 more
doaj   +1 more source