Results 21 to 30 of about 13,277 (283)

Comparative pathogenicity of vaccinia virus and mpox virus infections in CAST/EiJ mice: Exploring splenomegaly and transcriptomic profiles. [PDF]

Animal Model Exp Med
We successfully constructed CAST/EiJ mice models infected with low‐dose vaccinia virus (VACV‐L), high‐dose VACV (VACV‐H), and mpox virus (MPXV), demonstrating that VACV‐L and MPXV infections induced splenomegaly in mice, and VACV‐H infection caused mortality in mice.
Hou Y, Ma J, Huang B, Li N, Zhu L, Jia Z, Yang J, Zhang J, Tan W, Xue J.   +9 more
europepmc   +2 more sources

Two noncompeting human neutralizing antibodies targeting MPXV B6 show protective effects against orthopoxvirus infections [PDF]

Nature Communications
The recent outbreak of mpox epidemic, caused by monkeypox virus (MPXV), poses a new threat to global public health. Here, we initially assessed the preexisting antibody level to the MPXV B6 protein in vaccinia vaccinees born before the end of the ...
Runchu Zhao, Lili Wu, Junqing Sun, Dezhi Liu, Pu Han, Yue Gao, Yi Zhang, Yanli Xu, Xiao Qu, Han Wang, Yan Chai, Zhihai Chen, George F. Gao, Qihui Wang   +13 more
openalex   +2 more sources

Mpox multi-antigen mRNA vaccine candidates by a simplified manufacturing strategy afford efficient protection against lethal orthopoxvirus challenge

Emerging Microbes and Infections, 2023
Current unprecedented mpox outbreaks in non-endemic regions represent a global public health concern. Although two live-attenuated vaccinia virus (VACV)-based vaccines have been urgently approved for people at high risk for mpox, a safer and more ...
Jiawei Zeng, Yao Li, Linrui Jiang, Ling Luo, Yue Wang, Hao Wang, X. Han, Jian-Juan Zhao, Guanglei Gu, Min Fang, Qingrui Huang, Jielu Yan   +11 more
semanticscholar   +1 more source

Therapeutic and Prophylactic Drugs to Treat Orthopoxvirus Infections [PDF]

Future Virology, 2008
With the global eradication of smallpox in 1979, the causative agent, variola, no longer circulates in human populations. Other human poxvirus infections, such as those caused by vaccinia, cowpox virus and molluscum, are usually relatively benign in immunocompetent individuals.
Scott Parker, Lauren Handley, R. Mark L. Buller   +2 more
openalex   +3 more sources

Novel Orthopoxvirus and Lethal Disease in Cat, Italy [PDF]

Emerging Infectious Diseases, 2018
We report detection and full-genome characterization of a novel orthopoxvirus (OPXV) responsible for a fatal infection in a cat. The virus induced skin lesions histologically characterized by leukocyte infiltration and eosinophilic cytoplasmic inclusions. Different PCR approaches were unable to assign the virus to a defined OPXV species.
Gianvito Lanave, Giulia Dowgier, Nicola Decaro, Francesco Albanese, Elisa Brogi, Antonio Parisi, Michele Losurdo, Antonio Lavazza, Vito Martella, Canio Buonavoglia, Gabriella Elia   +10 more
openalex   +5 more sources

Orthopoxvirus targets for the development of new antiviral agents [PDF]

Antiviral Research, 2012
Investments in the development of new drugs for orthopoxvirus infections have fostered new avenues of research, provided an improved understanding of orthopoxvirus biology and yielded new therapies that are currently progressing through clinical trials.
Mark N. Prichard, Earl R. Kern
openalex   +4 more sources

Monkeypox Virus in Pregnancy, the Placenta and Newborn: An Emerging Poxvirus with Similarities to Smallpox and Other Orthopoxvirus Agents Causing Maternal and Fetal Disease.

Archives of Pathology & Laboratory Medicine, 2023
CONTEXT. – Before its eradication, the smallpox virus was a significant cause of poor obstetrical outcomes, including maternal and fetal morbidity and mortality.
D. Schwartz, Sandy Ha, P. Dashraath, D. Baud, P. Pittman, K. Waldorf   +5 more
semanticscholar   +1 more source

Gene duplication, gene loss, and recombination events with variola virus shaped the complex evolutionary path of historical American horsepox-based smallpox vaccines

mBio, 2023
Vaccinia virus is the active component of all modern smallpox vaccines after the mid-20th century, but it is uncertain to what extent cowpox, vaccinia, and horsepox viruses were used to produce vaccines before then.
Aline R. V. Souza, Annika Brinkmann, José Esparza, Andreas Nitsche, Clarissa R. Damaso   +4 more
doaj   +1 more source

Priming stroma with a vitamin D analog to optimize viroimmunotherapy for pancreatic cancer

Molecular Therapy: Oncolytics, 2022
Pancreatic cancer resistance to immunotherapies is partly due to deficits in tumor-infiltrating immune cells and stromal density. Combination therapies that modify stroma and recruit immune cells are needed.
Sang-In Kim, Shyambabu Chaurasiya, Venkatesh Sivanandam, Seonah Kang, Anthony K. Park, Jianming Lu, Annie Yang, Zhifang Zhang, Isabella A. Bagdasarian, Yanghee Woo, Joshua T. Morgan, Zhirong Yin, Yuman Fong, Susanne G. Warner   +13 more
doaj   +1 more source

Unexpectedly higher levels of anti-orthopoxvirus neutralizing antibodies are observed among gay men than general adult population

BMC Medicine, 2023
Background The confirmed cases in the current outbreak of Monkeypox are predominantly identified in the networks of men who have sex with men (MSM). The preexisting antibodies may profoundly impact the transmission of monkeypox virus (MPXV), however the ...
Yanmeng Feng, Yifan Zhang, Sheng-ya Liu, Meng Guo, Haojie Huang, Cuiyuan Guo, Wan-Hai Wang, Wen Zhang, Heng Tang, Y. Wan   +9 more
semanticscholar   +1 more source