Results 41 to 50 of about 7,142 (165)

Mpox (Monkeypox) in Pregnancy Updates

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Mpox is a zoonotic viral disease caused by the monkeypox virus, with potential for significant morbidity across all population groups, including pregnant individuals and neonates. Pregnancy represents an immunologically vulnerable state, rendering affected mothers more susceptible to severe disease progression.
Yeshey Dorjey, Deep Kiran Chhetri
wiley   +1 more source

Mpox Outbreak in the East Africa Region: Current Status, Containment Measures, Challenges, and Future Direction

Public Health Challenges, Volume 5, Issue 1, March 2026.
The WHO declares the Mpox outbreak a Public Health Emergency of International Concern, with the DRC as the epicenter in the EAC. DRC, Uganda, and Burundi experience extensive transmission; Kenya and Uganda show higher case fatality rates. Containment measures include surveillance, public awareness, infection prevention training, and vaccination (>73 ...
Reuben Sindayiheba, Noel Gahamanyi, Jerome Ndayisenga, Edouard Ntagwabira, Emmanuel Nsengiyumva, Emmanuel Kabalisa, Gashegu Misbah, Isabelle Mukagatare, Leon Mutesa, Claude Mambo Muvunyi   +9 more
wiley   +1 more source

Genesis of Monkeypox

Journal of Pure and Applied Microbiology, 2022
A zoonotic orthopoxvirus known as monkeypox inadvertently produces a smallpox-like illness in humans but with far fewer fatalities. This infection is indigenous to most parts of the African continent, with outbreaks throughout the Western World linked to
Abdul Basit, Jasni Mohamad Zain, Hafiza Zoya Mojahid, Mushtaq Ali   +3 more
doaj   +1 more source

Ensemble Docking of FDA‐Approved and Peruvian Phytochemicals Against Monkeypox Virus Telomere‐Binding Protein

ChemistrySelect, Volume 11, Issue 9, 5 March 2026.
ABSTRACT Monkeypox is a reemerging zoonotic disease that has been spreading worldwide. Different approaches are being conducted to find effective treatments for this disease. To accelerate therapeutic discovery, we propose telomere‐binding protein (TBP) as a potential drug target because of its important role during virus maturation.
Edinson Gervacio‐Villarreal, Georcki Ropón‐Palacios, Claudina Sancho, Jhon Pérez‐Silva, Kewin Otazu, Gustavo E. Olivos‐Ramirez, Karolyn Vega‐Chozo, Yaritza L. Ramirez‐Díaz, Manuel E. Chenet‐Zuta, Ivonne Navarro del Aguila, Mario De la Cruz Flores, Cinthia Aguiar, Ihosvany Camps   +12 more
wiley   +1 more source

Seasonality of human orthopoxvirus infections

, 2022
Variola infections (smallpox) showed seasonality in temperate climates. This sharp seasonality (peaking in the Winter-Spring) may have important ramifications for control and elimination of human monkeypox (MPX) and should be considered in planning public health response.
Andrew Lover, Andrew Noymer
openaire   +1 more source

Novel Orthopoxvirus Infection in an Alaska Resident [PDF]

Clinical Infectious Diseases, 2017
Human infection by orthopoxviruses is being reported with increasing frequency, attributed in part to the cessation of smallpox vaccination and concomitant waning of population-level immunity. In July 2015, a female resident of interior Alaska presented to an urgent care clinic with a dermal lesion consistent with poxvirus infection. Laboratory testing
Springer, Yuri P., Hsu, Christopher H., Werle, Zachary R., Olson, Link E., Cooper, Michael P., Castrodale, Louisa J., Fowler, Nisha, McCollum, Andrea M., Goldsmith, Cynthia S., Emerson, Ginny L., Wilkins, Kimberly, Doty, Jeffrey B., Burgado, Jillybeth, Gao, JinXin, Patel, Nishi, Mauldin, Matthew R., Reynolds, Mary G., Satheshkumar, Panayampalli S., Davidson, Whitni, Li, Yu, McLaughlin, Joseph B.   +20 more
openaire   +2 more sources

An mRNA Vaccine Based on Antigens From Conserved Regions of Monkeypox Virus A35R and M1R With a Dimer‐Like Conformation Confers Protection Against Both Monkeypox Virus and Vaccinia Virus Infections in Mice

MedComm, Volume 7, Issue 2, February 2026.
We developed four candidate mRNA vaccine antigens based on conserved sequences of MPXV A35R and M1R proteins. Our findings demonstrate that the MV2 vaccine possesses favorable immunogenicity and prophylactic potential against MPXV and VACV infections, positioning it as a promising clinical candidate for MPXV prevention.
Cong Tang, Longhai Yuan, Yun Xie, Yun Yang, Yanan Zhou, Junbing Wang, Hao Yang, Rui Peng, Jiali Xu, Wenhai Yu, Qing Huang, Wenqi Quan, Baisheng Li, Youchun Wang, Shuaiyao Lu   +14 more
wiley   +1 more source

Ophthalmic Features and Implications of Poxviruses: Lessons from Clinical and Basic Research

Microorganisms, 2022
Amidst the ongoing monkeypox outbreak, global awareness has been directed towards the prevention of viral transmission and case management, with the World Health Organization declaring the outbreak a public health emergency of international concern ...
Tolulope Fashina, Ye Huang, Joanne Thomas, Christopher D. Conrady, Steven Yeh   +4 more
doaj   +1 more source

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
wiley   +1 more source

Smallpox, Monkeypox and Other Human Orthopoxvirus Infections

Viruses, 2022
Considering that vaccination against smallpox with live vaccinia virus led to serious adverse effects in some cases, the WHO, after declaration of the global eradication of smallpox in 1980, strongly recommended to discontinue the vaccination in all countries.
Galina A. Shchelkunova, Sergei N. Shchelkunov   +1 more
openaire   +3 more sources