Results 41 to 50 of about 7,538 (211)

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

open access: yesAdvanced Science, Volume 13, Issue 4, 19 January 2026.
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei   +12 more
wiley   +1 more source

Overview of Diagnostic Methods, Disease Prevalence and Transmission of Mpox (Formerly Monkeypox) in Humans and Animal Reservoirs

open access: yesMicroorganisms, 2023
Mpox—formerly monkeypox—is a re-emerging zoonotic virus disease, with large numbers of human cases reported during multi-country outbreaks in 2022. The close similarities in clinical symptoms that Mpox shares with many orthopoxvirus (OPXV) diseases make ...
Ravendra P. Chauhan   +2 more
doaj   +1 more source

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

open access: yesSmall Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N   +2 more
wiley   +1 more source

Fatal Cowpox Virus Infection in Human Fetus, France, 2017

open access: yesEmerging Infectious Diseases, 2021
Cowpox virus (CPXV) has an animal reservoir and is typically transmitted to humans by contact with infected animals. In 2017, CPXV infection of a pregnant woman in France led to the death of her fetus.
Audrey Ferrier   +10 more
doaj   +1 more source

Operationalizing a Hub‐and‐Spoke Telemedicine Model for Mpox Surveillance in a High‐Alert, Zero‐Prevalence Setting: An Observational Study, Real‐World Experience From Iran

open access: yesInterdisciplinary Perspectives on Infectious Diseases, Volume 2026, Issue 1, 2026.
Background The global monkeypox (Mpox) outbreak prompted heightened surveillance in regions with significant travel links. Fars Province, Iran, implemented a structured telemedicine response to manage patients presenting with Mpox‐like symptoms. Objectives This study aimed to describe and evaluate the impact of a tiered, hub‐and‐spoke telemedicine ...
Owrang Eilami   +5 more
wiley   +1 more source

The Impact of Monkeypox Virus Infection on Pregnancy Outcome: Clinical Features and Potential Pathogenic Mechanisms

open access: yesJournal of Immunology Research, Volume 2026, Issue 1, 2026.
Monkeypox has garnered significant attention following its emergence in multiple countries and its designation as a global health emergency in 2022. There is a notable deficiency in clinical and experimental data regarding pregnancy outcomes following monkeypox infection.
Jingyi Wu   +3 more
wiley   +1 more source

Seasonality of human orthopoxvirus infections

open access: yes, 2022
Variola infections (smallpox) showed seasonality in temperate climates. This sharp seasonality (peaking in the Winter-Spring) may have important ramifications for control and elimination of human monkeypox (MPX) and should be considered in planning public health response.
Andrew Lover, Andrew Noymer
openaire   +1 more source

Novel Orthopoxvirus Infection in an Alaska Resident [PDF]

open access: yesClinical Infectious Diseases, 2017
Human infection by orthopoxviruses is being reported with increasing frequency, attributed in part to the cessation of smallpox vaccination and concomitant waning of population-level immunity. In July 2015, a female resident of interior Alaska presented to an urgent care clinic with a dermal lesion consistent with poxvirus infection. Laboratory testing
Springer, Yuri P.   +20 more
openaire   +2 more sources

Genesis of Monkeypox

open access: yesJournal of Pure and Applied Microbiology, 2022
A zoonotic orthopoxvirus known as monkeypox inadvertently produces a smallpox-like illness in humans but with far fewer fatalities. This infection is indigenous to most parts of the African continent, with outbreaks throughout the Western World linked to
Abdul Basit   +3 more
doaj   +1 more source

Susceptibility to monkeypox virus infection: seroprevalence of orthopoxvirus in 4 population samples; France, Bolivia, Laos and Mali [PDF]

open access: gold, 2022
Léa Lucıanı   +11 more
openalex   +1 more source

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