Results 61 to 70 of about 11,507 (279)

ENDEMIC ORTHOPOXVIRUS CIRCULATING IN PROCYONIDS IN MEXICO [PDF]

Journal of Wildlife Diseases, 2016
Limited serosurveillance studies suggested that orthopoxviruses (OPXV) are widespread in the US (e.g., Raccoonpox virus, Skunkpox virus, Volepox virus) and Brazil (Vaccinia virus); however, their animal reservoir(s) remain unconfirmed. Mexican mammal diversity includes several species related to those in which evidence for OPXV infections has been ...
Lilia María Gama-Campillo, Alvaro Aguilar-Setién, Nadia F. Gallardo-Romero, Ginny L. Emerson, Jeffrey B. Doty, Claudia Villanueva-García, Darin S. Carroll, Emilio Rendón-Franco, Fernando Gual-Sill, Fernando Gual-Sill, Citlali Ramírez-Cid, Yoshinori J. Nakazawa, Claudia I. Muñoz-García, Nidia Aréchiga-Ceballos, Flor Olivia Martínez-Martínez   +14 more
openaire   +3 more sources

Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans

Frontiers in Public Health, 2018
Monkeypox is an emerging zoonotic disease recognized as the most important orthopoxvirus infection in humans in the smallpox post-eradication era. The clinical presentation of monkeypox is similar to the one of smallpox.
Nikola Sklenovská, M. Van Ranst
semanticscholar   +1 more source

Diagnosis of Imported Monkeypox, Israel, 2018

Emerging Infectious Diseases, 2019
We report a case of monkeypox in a man who returned from Nigeria to Israel in 2018. Virus was detected in pustule swabs by transmission electron microscopy and PCR and confirmed by immunofluorescence assay, tissue culture, and ELISA.
Noam Erez, Hagit Achdout, Elad Milrot, Yuval Schwartz, Yonit Wiener-Well, Nir Paran, Boaz Politi, Hadas Tamir, Tomer Israely, Shay Weiss, Adi Beth-Din, Ohad Shifman, Ofir Israeli, Shmuel Yitzhaki, Shmuel C. Shapira, Sharon Melamed, Eli Schwartz   +16 more
doaj   +1 more source

A Glance at the Development and Patent Literature of Tecovirimat: The First-in-Class Therapy for Emerging Monkeypox Outbreak

Viruses, 2022
Monkeypox disease (MPX) is currently considered a global threat after COVID-19. European Medicines Agency (EMA) approved Tecovirimat in capsule dosage form (200 mg) as the first treatment for MPX in January 2022.
Mazen Almehmadi, Mamdouh Allahyani, Ahad Amer Alsaiari, Mohammed Kanan Alshammari, Abrar Saleh Alharbi, Khansa Hamza Hussain, Lojain Ibrahim Alsubaihi, Mehnaz Kamal, Shahad Saleh Alotaibi, Atheer Nasser Alotaibi, Afeefah Awaid Aldhafeeri, Mohd Imran   +11 more
doaj   +1 more source

Genomic Sequencing and Analysis of a Novel Human Cowpox Virus With Mosaic Sequences From North America and Old World Orthopoxvirus

Frontiers in Microbiology, 2022
Orthopoxviruses (OPXVs) not only infect their natural hosts, but some OPXVs can also cause disease in humans. Previously, we partially characterized an OPXV isolated from an 18-year-old male living in Northern Norway.
Diana Diaz-Cánova, U. Moens, A. Brinkmann, A. Nitsche, M. I. Okeke   +4 more
semanticscholar   +1 more source

Vaccinia Virus Serpin-1 Deletion Mutant Exhibits a Host Range Defect Characterized by Low Levels of Intermediate and Late mRNAs [PDF]

, 1999
Orthopoxviruses encode three serpin homologs—SPI-1, SPI-2 and SPI-3—of which SPI-2 has been well characterized as an inhibitor of ICE-like proteases. A rabbitpox virus SPI-1 deletion mutant exhibited a host range restriction in human lung A549 and pig ...
Isaacs, Stuart N., Moss, Bernard, Shisler, Joanna L.   +2 more
core   +1 more source

Priming stroma with a vitamin D analog to optimize viroimmunotherapy for pancreatic cancer

Molecular Therapy: Oncolytics, 2022
Pancreatic cancer resistance to immunotherapies is partly due to deficits in tumor-infiltrating immune cells and stromal density. Combination therapies that modify stroma and recruit immune cells are needed.
Sang-In Kim, Shyambabu Chaurasiya, Venkatesh Sivanandam, Seonah Kang, Anthony K. Park, Jianming Lu, Annie Yang, Zhifang Zhang, Isabella A. Bagdasarian, Yanghee Woo, Joshua T. Morgan, Zhirong Yin, Yuman Fong, Susanne G. Warner   +13 more
doaj  

Hazard Characterization of Modified Vaccinia Virus Ankara Vector: What Are the Knowledge Gaps?

Viruses, 2017
Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo.
Malachy I. Okeke, Arinze S. Okoli, Diana Diaz, Collins Offor, Taiwo G. Oludotun, Morten Tryland, Thomas Bøhn, Ugo Moens   +7 more
doaj   +1 more source

Rapid and high-throughput pan-Orthopoxvirus detection and identification using PCR and mass spectrometry. [PDF]

PLoS ONE, 2009
The genus Orthopoxvirus contains several species of related viruses, including the causative agent of smallpox (Variola virus). In addition to smallpox, several other members of the genus are capable of causing human infection, including monkeypox ...
Mark W Eshoo, Chris A Whitehouse, Aysegul Nalca, Scott Zoll, Joseph A Ecker, Thomas A Hall, Thuy-Trang D Pennella, David D Duncan, Anjali Desai, Emily K Moradi, Karl Rudnick, Brian Libby, Raymond Ranken, Rangarajan Sampath, Steven A Hofstadler, David J Ecker, Lawrence B Blyn   +16 more
doaj   +1 more source

Seasonality of human orthopoxvirus infections

, 2022
Variola infections (smallpox) showed seasonality in temperate climates. This sharp seasonality (peaking in the Winter-Spring) may have important ramifications for control and elimination of human monkeypox (MPX) and should be considered in planning public health response.
Andrew Lover, Andrew Noymer
openaire   +1 more source