Results 61 to 70 of about 7,538 (211)

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, Volume 58, Issue 11, November 2025.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Potential Risk of Local Transmission of Mpox in Nepal: An Emerging Public Health Concern

Health Science Reports, Volume 8, Issue 9, September 2025.
ABSTRACT Background and Aims Monkeypox (Mpox) is a zoonotic disease caused by the monkeypox virus, a double‐stranded DNA virus of the Orthopoxvirus genus with two major clades (Clades I and II), with Clade IIb responsible for most global cases reported during 2022–2024.
Yogendra Shah, Ankit Kumar Singh, Bipin Kumar Acharya, Mandira Lamichhane, Ram Singh Dhami, Kishor Pandey, Shyam Prakash Dumre, Kouichi Morita, Basu Dev Pandey, Meghnath Dhimal   +9 more
wiley   +1 more source

Orthopoxvirus infection transmitted by a domestic cat

Journal of the American Academy of Dermatology, 2006
The variola virus was declared eradicated by the World Health Organization in 1980 but human infections by cowpox virus, another member of the genus Orthopoxvirus, are still observed, mainly in European countries. We report a woman who presented with two umbilicated vesicles surrounded by an indurated erythematous edema within cat scratch injuries on ...
Haenssle, Holger Andreas, Kiessling, J., Kempf, Volkhard A. J., Fuchs, Tina, Neumann, C., Emmert, Steffen   +5 more
openaire   +3 more sources

Co-Circulating Monkeypox and Swinepox Viruses, Democratic Republic of the Congo, 2022

Emerging Infectious Diseases
In September 2022, deaths of pigs manifesting pox-like lesions caused by swinepox virus were reported in Tshuapa Province, Democratic Republic of the Congo. Two human mpox cases were found concurrently in the surrounding community.
Thierry Kalonji, Emile Malembi, Jean Paul Matela, Toutou Likafi, Eddy Kinganda-Lusamaki, Emmanuel Hasivirwe Vakaniaki, Nicole A. Hoff, Amuri Aziza, Francisca Muyembe, Joelle Kabamba, Tine Cooreman, Béatrice Nguete, Danae Witte, Ahidjo Ayouba, Nicolas Fernandez-Nuñez, Stijn Roge, Martine Peeters, Sydney Merritt, Steve Ahuka-Mundeke, Eric Delaporte, Elisabeth Pukuta, Joachim Mariën, Eugene Bangwen, Steven Lakin, Charles Lewis, Jeffrey B. Doty, Laurens Liesenborghs, Lisa E. Hensley, Andrea McCollum, Anne W. Rimoin, Jean Jacques Muyembe-Tamfum, Robert Shongo, Didine Kaba, Placide Mbala-Kingebeni   +33 more
doaj   +1 more source

A Pyrido‐Quinoxaline Derivative That Downregulates Reticulon 3 Protein Exhibits Potent Antiviral Activity Against Zika Virus

Journal of Medical Virology, Volume 97, Issue 9, September 2025.
ABSTRACT In the wake of the COVID‐19 pandemic, awareness of emerging pathogens has significantly increased, prompting greater investment in research and preparedness. In this context, arboviral diseases are recognized as unmet medical challenges due to their rapid spread. Notably, the geographical range of several flaviviral diseases is expanding: Zika
Erika Plicanti, Andrea Deiana, Silvia Nottoli, Giulia Lottini, Roberta Ibba, Sandra Piras, Carlo Di Marzo, Silvia Vegni, Michele Lai, Mauro Pistello, Antonio Carta, Giulia Freer   +11 more
wiley   +1 more source

Diagnostic electron microscopy in human infectious diseases – Methods and applications

Journal of Microscopy, Volume 299, Issue 3, Page 186-205, September 2025.
Abstract Diagnostic electron microscopy (EM) is indispensable in all cases of infectious diseases which deserve or profit from the detection of the entire pathogen (i.e. the infectious unit). The focus of its application has shifted during the last decades from routine diagnostics to diagnostics of special cases, emergencies and the investigation of ...
Michael Laue
wiley   +1 more source

Orthopoxvirus Infections: Epidemiology, Clinical Picture, and Diagnostics (Scientific Review)

Проблемы особо опасных инфекций, 2013
Lack of immunity among the population against pathogenic orthopoxviruses and an increased number of these infections human cases testify to the need of development of the rapid high-sensitive methods for species-specific orthopoxvirus diagnostics.
E. V. Gavrilova, R. A. Maksyutov, S. N. Shchelkunov   +2 more
doaj   +1 more source

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, Volume 12, Issue 26, July 10, 2025.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

Short-Lived Neutralizing Antibody Responses to Monkeypox Virus in Smallpox Vaccine–Naive Persons after JYNNEOS Vaccination

Emerging Infectious Diseases
JYNNEOS, a third-generation smallpox vaccine, is integral to monkeypox virus (MPXV) control efforts, but the durability of this modified vaccinia Ankara–Bavarian Nordic (MVA-BN) vaccine’s effectiveness is undefined.
Kara Phipps, Jennifer Yates, Jessica Pettit, Sean Bialosuknia, Danielle Hunt, Alan P. DuPuis, Anne Payne, William Lee, Kathleen A. McDonough   +8 more
doaj   +1 more source

Low Specific T‐Cell Immunity Against Mpox Elicited in People With HIV‐1 and PrEP Users After Subcutaneous Vaccination Compared to Natural Infection

Journal of Medical Virology, Volume 97, Issue 7, July 2025.
ABSTRACT In August 2024, the World Health Organization declared mpox infection a Public Health Emergency of International Concern for second time since 2022 and recommended vaccinating all people at‐risk, such as people with HIV‐1 (PWH) and prophylaxis pre‐exposition (PrEP) users.
Olivia de la Calle‐Jiménez, Guiomar Casado‐Fernández, Inés Armenteros‐Yeguas, Luis Lemus‐Aguilar, Begoña Baza, Jorge Alfredo Pérez‐García, Javier Rodríguez‐Añover, Elena Mateos, Reynaldo Homen, Eva Orviz‐García, Noemí Cabello, Anabel Negredo, María Paz Sánchez Seco, Jorge del Romero, Vicente Estrada, Montserrat Torres, Mayte Coiras   +16 more
wiley   +1 more source