Results 91 to 100 of about 1,311,722 (333)

Oscillating on Borrowed Time: Diffusible Signals from Immortalized Suprachiasmatic Nucleus Cells Regulate Circadian Rhythmicity in Cultured Fibroblasts [PDF]

The Journal of Neuroscience, 2001
The capacity to generate circadian rhythms endogenously and to confer this rhythmicity to other cells was compared in immortalized cells derived from the suprachiasmatic nucleus (SCN) and a fibroblast line to differentiate SCN pacemaker properties from the oscillatory behavior of non-clock tissues.
G, Allen, J, Rappe, D J, Earnest, V M, Cassone   +3 more
openaire   +2 more sources

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Remodeling of calcium signaling and store operated calcium entry as a consequence of human neural progenitor cell differentiation

Scientific Reports
The differentiation of neural progenitor cells into glial and neuronal lineages is a fundamental process in neurodevelopment. This complex process is tightly regulated by several signaling pathways, including calcium signaling. Calcium signaling not only
Silke B. Chalmers, Mélanie Robitaille, Francisco Sadras, Sarah J. Roberts-Thomson, Gregory R. Monteith   +4 more
doaj   +1 more source

Oscillatory Ca2+ Signaling in the Isolated Caenorhabditis elegans Intestine

The Journal of General Physiology, 2005
Defecation in the nematode Caenorhabditis elegans is a readily observable ultradian behavioral rhythm that occurs once every 45–50 s and is mediated in part by posterior body wall muscle contraction (pBoc).
M. Espelt, A. Estevez, Xiaoyan Yin, K. Strange   +3 more
semanticscholar   +1 more source

Design Principles of Pancreatic Islets: Glucose-dependent Coordination of Hormone Pulses

, 2015
Pancreatic islets are functional units involved in glucose homeostasis. The multicellular system comprises three main cell types; $\beta$ and $\alpha$ cells reciprocally decrease and increase blood glucose by producing insulin and glucagon pulses, while ...
Hara, Manami, Hoang, Danh-Tai, Jo, Junghyo   +2 more
core   +3 more sources

Neurosystems: brain rhythms and cognitive processing [PDF]

, 2013
Neuronal rhythms are ubiquitous features of brain dynamics, and are highly correlated with cognitive processing. However, the relationship between the physiological mechanisms producing these rhythms and the functions associated with the rhythms remains ...
Börgers, Christoph, Cannon, Jonathan, Kopell, Nancy, Lee, Jung, Lee, Shane, McCarthy, Michelle M., Whittington, Miles A.   +6 more
core   +1 more source

Repetitive mitochondrial Ca 2+ signals synchronize with cytosolic Ca 2+ oscillations in the pancreatic beta-cell line, MIN6 [PDF]

Diabetologia, 1998
We examined the relationship between cytosolic Ca2+ concentration ([Ca2+]c) and mitochondrial matrix Ca2+ concentration ([Ca2+]m) in the pancreatic beta-cell line, MIN6. [Ca2+]c was monitored in a single or a group (30 cells) of fura-2-loaded MIN6 cells, and [Ca2+]m was measured in a group (1 x 10[6] cells) of MIN6 cells stably transfected with ...
M, Nakazaki, H, Ishihara, M, Kakei, K, Inukai, T, Asano, J I, Miyazaki, H, Tanaka, M, Kikuchi, T, Yada, Y, Oka   +9 more
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Regulation of molecular clock oscillations and phagocytic activity via muscarinic Ca2+ signaling in human retinal pigment epithelial cells [PDF]

Scientific Reports, 2017
AbstractVertebrate eyes are known to contain circadian clocks, however, the intracellular mechanisms regulating the retinal clockwork remain largely unknown. To address this, we generated a cell line (hRPE-YC) from human retinal pigmental epithelium, which stably co-expressed reporters for molecular clock oscillations (Bmal1-luciferase) and ...
Rina Ikarashi, Honami Akechi, Yuzuki Kanda, Alsawaf Ahmad, Kouhei Takeuchi, Eri Morioka, Takashi Sugiyama, Takashi Ebisawa, Masaaki Ikeda, Masayuki Ikeda   +9 more
openaire   +2 more sources

Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes

The Journal of General Physiology, 1994
Stimulation through the antigen receptor (TCR) of T lymphocytes triggers cytosolic calcium ([Ca2+]i) oscillations that are critically dependent on Ca2+ entry across the plasma membrane.
R. Dolmetsch, R. Lewis
semanticscholar   +1 more source