Results 71 to 80 of about 1,502,375 (350)
Frontiers in Cell and Developmental Biology, 2019 The mammalian target of rapamycin (mTOR) is an evolutionarily conserved kinase which assembles a signaling network that integrates diverse biochemical and mechanical cues to coordinate cell growth and proliferation.
Shan-Shan Lin, Ya-Wen Liu, Ya-Wen Liu
doaj +1 more source
Human iNKT Cells Promote Protective Inflammation by Inducing Oscillating Purinergic Signaling in Monocyte-Derived DCs [PDF]
Cell Reports, 2016 Invariant natural killer T (iNKT) cells are innate T lymphocytes that promote host defense against a variety of microbial pathogens. Whether microbial ligands are required for their protective effects remains unclear. Here, we show that iNKT cells stimulate human-monocyte-derived dendritic cells (DCs) to produce inflammatory mediators in a manner that ...
Nathan M. Sherer +11 more
openaire +4 more sources
The role of calcium oscillations in the phenotype selection in endothelial cells
Scientific Reports, 2021 Angiogenesis is an important process in the formation and maintenance of tissues which is driven by a complex system of intracellular and intercellular signaling mechanisms.
Birses Debir +3 more
doaj +1 more source
, 2012 Unveiling the mechanisms through which the somitogenesis regulatory network exerts spatiotemporal control of the somitic patterning has required a combination of experimental and mathematical modeling strategies.
Santillán, Moisés, Zavala, Eder
core +1 more source
Noise control and utility: From regulatory network to spatial patterning [PDF]
, 2020 Stochasticity (or noise) at cellular and molecular levels has been observed extensively as a universal feature for living systems. However, how living systems deal with noise while performing desirable biological functions remains a major mystery ...
Nie, Qing +4 more
core +1 more source
Cell Cycle, 2012 Most physiological and biological processes are regulated by endogenous circadian rhythms under the control of both a master clock, which acts systemically and individual cellular clocks, which act at the single cell level. The cellular clock is based on
Stefano Rossetti +4 more
semanticscholar +1 more source
Signaling oscillations: molecular mechanisms and functional roles [PDF]
arXiv, 2022 Mounting evidence shows that oscillatory activity is widespread in cell signaling. Here we review some of this recent evidence, focusing on both the molecular mechanisms that potentially underlie such dynamical behavior, and the potential advantages that signaling oscillations might have in cell function.
arxiv
Inherent rhythm of smooth muscle cells in rat mesenteric arterioles: an eigensystem formulation [PDF]
Phys. Rev. E 93, 042415 (2016), 2016 On the basis of experimental data and mathematical equations in the literature, we remodel the ionic dynamics of smooth muscle cells (SMCs) as an eigensystem formulation, which is valid for investigating finite variations of variables from the equilibrium like in common experimental operations.
arxiv +1 more source
A mathematical model coupling polarity signaling to cell adhesion explains diverse cell migration patterns [PDF]
, 2016 Cells crawling through tissues migrate inside a complex fibrous environment called the extracellular matrix (ECM), which provides signals regulating motility. Here we investigate one such well-known pathway, involving mutually antagonistic signalling molecules (small GTPases Rac and Rho) that control the protrusion and contraction of the cell edges ...
arxiv +1 more source
Parametric modeling of mechanical effects on circadian oscillators [PDF]
arXiv, 2023 Circadian rhythms are archetypical examples of nonlinear oscillations. While these oscillations are usually attributed to circuits of biochemical interactions among clock genes and proteins, recent experimental studies reveal that they are also affected by the cell's mechanical environment.
arxiv