Results 71 to 80 of about 50,029 (292)

Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β

Advanced Biology, EarlyView.
This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer, Markus Michael Kramer, Miguel Baños, Merlin Moritz Grimm, Manfred Fliegauf, Bodo Grimbacher, Gerald Radziwill, Sven Rahmann, Wilfried Weber   +8 more
wiley   +1 more source

Epilepsy protein myoclonin1 interacts with inositol 1,4,5-trisphosphate receptor and reduces calcium ions stored in endoplasmic reticulum [PDF]

Exploration of Neuroscience
Aim: Mutations in the EFHC1 gene have been identified in patients with various epilepsies, including juvenile myoclonic epilepsy (JME). Mice with Efhc1 deficiency also exhibit epileptic phenotypes.
Toshimitsu Suzuki, Kripamoy Aguan, Hideaki Mizuno, Ikuyo Inoue, Katsuhiko Mikoshiba, Atsushi Miyawaki, Kazuhiro Yamakawa   +6 more
doaj   +1 more source

Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase [PDF]

, 2012
Cilia of olfactory sensory neurons are the primary sensory organelles for olfaction. The detection of odorants by the main olfactory epithelium (MOE) depends on coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) in olfactory cilia.
Chen, Xuanmao, Storm, Daniel R., Xia, Zhengui   +2 more
core   +2 more sources

Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts – from General Tissue Engineering to Cellular Agriculture

Advanced Biology, EarlyView.
Using supramolecular monomers, various hydrogel culture systems were formulated to culture protoplasts; including 2D, 2.5D, and 3D hydrogels. Depending on the culture platform, bioactive functionalization led to protoplast enlargement (2D and 2.5D) or plasmolysis (3D). This work shows the potential to modularly engineer synthetic platforms for cellular
Maritza M. Rovers, Erik J. Slootweg, Ferdinand C. O. Los, Patricia Y. W. Dankers   +3 more
wiley   +1 more source

Sequential pattern formation governed by signaling gradients

, 2016
Rhythmic and sequential segmentation of the embryonic body plan is a vital developmental patterning process in all vertebrate species. However, a theoretical framework capturing the emergence of dynamic patterns of gene expression from the interplay of ...
Jörg, David J., Jülicher, Frank, Oates, Andrew C.   +2 more
core   +1 more source

Neurosystems: brain rhythms and cognitive processing [PDF]

, 2013
Neuronal rhythms are ubiquitous features of brain dynamics, and are highly correlated with cognitive processing. However, the relationship between the physiological mechanisms producing these rhythms and the functions associated with the rhythms remains ...
Börgers, Christoph, Cannon, Jonathan, Kopell, Nancy, Lee, Jung, Lee, Shane, McCarthy, Michelle M., Whittington, Miles A.   +6 more
core   +1 more source

Ag Cluster‐Modified K0.5Na0.5NbO3 Piezocatalyst for Enhanced Electrochemical Dinitrogen Reduction Reaction

Advanced Engineering Materials, EarlyView.
Ag cluster‐modified K0.5Na0.5NbO3 acts as an efficient piezocatalyst for electrochemical N2 reduction, enhanced by built‐in electric fields under mechanical actuation. Comparative studies between static and actuated electrodes reveal improved performance under dynamic conditions.
Benedict Witulski, Naina Goyal, David Patrun, Fabio Pires, Ziyaad Aytuna, Hamed Alaei, Olav Schiemann, Sanjay Mathur   +7 more
wiley   +1 more source

Ultrahigh Piezoelectricity in Truss‐Based Ferroelectric Ceramics Metamaterials

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
By leveraging the unique combination of polarization direction and loading state, ultrahigh piezoelectricity is achieved through careful tuning of the relative density and scaling ratio in truss‐based ferroelectric metamaterials. This approach enables the simultaneous realization of extremely high piezoelectric constants and ultralow dielectric ...
Jiahao Shi, Kang Ju, Haoyu Chen, Valérie Orsat, Agus P. Sasmito, Ali Ahmadi, Abdolhamid Akbarzadeh   +6 more
wiley   +1 more source

Formation of transient lamellipodia. [PDF]

PLoS ONE, 2014
Cell motility driven by actin polymerization is pivotal to the development and survival of organisms and individual cells. Motile cells plated on flat substrates form membrane protrusions called lamellipodia. The protrusions repeatedly appear and retract
Juliane Zimmermann, Martin Falcke
doaj   +1 more source

Engineering the Hierarchical Porosity of Granular Hydrogel Scaffolds Using Porous Microgels to Improve Cell Recruitment and Tissue Integration

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
By fabricating and covalently assembling gelatin methacryloyl (GelMA) porous microgels, a new class of granular hydrogel scaffolds with hierarchical porosity is developed. These scaffolds have a significantly higher void fraction than their counterparts made up of nonporous microgels, enhancing cell recruitment and tissue integration. This research may
Alexander Kedzierski, Sina Kheirabadi, Arian Jaberi, Zaman Ataie, Catherine L. Mojazza, Marisa L. Williamson, Anton M. Hjaltason, Aneesh Risbud, Yuanhui Xiang, Amir Sheikhi   +9 more
wiley   +1 more source