Results 81 to 90 of about 1,282,481 (350)

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

CDPKs CPK6 and CPK3 function in ABA regulation of guard cell S-type anion- and Ca(2+)-permeable channels and stomatal closure.

PLoS Biology, 2006
Abscisic acid (ABA) signal transduction has been proposed to utilize cytosolic Ca(2+) in guard cell ion channel regulation. However, genetic mutants in Ca(2+) sensors that impair guard cell or plant ion channel signaling responses have not been ...
Izumi C Mori, Yoshiyuki Murata, Yingzhen Yang, Shintaro Munemasa, Yong-Fei Wang, Shannon Andreoli, Hervé Tiriac, Jose M Alonso, Jeffery F Harper, Joseph R Ecker, June M Kwak, Julian I Schroeder   +11 more
doaj   +1 more source

Distinct anti-dyskinetic effects of amantadine and group II metabotropic glutamate receptor agonist LY354740 in a rodent model: An electrophysiological perspective

Neurobiology of Disease, 2020
L-DOPA-induced dyskinesia (LID) is a major complication of long-term dopamine replacement therapy in Parkinson's disease. Characteristic neural oscillation and abnormal activity of striatal projection neurons (SPNs) are typical pathological events of LID,
Cong Zheng, Yan Xu, Guiqin Chen, Yang Tan, Weiqi Zeng, Ji Wang, Chi Cheng, Xiaoman Yang, Shuke Nie, Zhentao Zhang, Xuebing Cao   +10 more
doaj   +1 more source

It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]

, 2016
The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core   +2 more sources

LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease

Arthritis Care &Research, Accepted Article.
Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla, Robert Lafyatis, Kevin F Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J Kass   +13 more
wiley   +1 more source

Lattice gas cellular automata model for rippling and aggregation in myxobacteria

, 2004
A lattice-gas cellular automaton (LGCA) model is used to simulate rippling and aggregation in myxobacteria. An efficient way of representing cells of different cell size, shape and orientation is presented that may be easily extended to model later ...
Buchard, Börner, Dworkin, Gronewold, Hagen, Hodgkin, Hodgkin, Igoshin, Jelsbak, Jelsbak, Jiang, Julien, Kim, Kim, Kim, Kim, Kim, Kroos, Kruse, Li, Lutscher, Marée, Reichenbach, Sager, Sager, Shi, Shimkets, Shimkets, Shimkets, Stevens, Vasquez, Welch, Wolgemuth   +32 more
core   +1 more source

A new multicompartmental reaction-diffusion modeling method links transient membrane attachment of E. coli MinE to E-ring formation [PDF]

, 2009
Many important cellular processes are regulated by reaction-diffusion (RD) of molecules that takes place both in the cytoplasm and on the membrane. To model and analyze such multicompartmental processes, we developed a lattice-based Monte Carlo method ...
A Minton, A Szabo, AD Dupuy, AV Popov, AV Popov, B Huang, B Treanor, C Sanford, CA Gomez-Uribe, CH Hansen, CL Woldringh, CL Woldringh, CV Rao, D Fange, D Greenfield, D Hall, D Ramos, D Ridgway, D Ridgway, DA Drew, DC Clarke, DM Morris, DM Raskin, DM Raskin, DT Gillespie, DT Gillespie, DW Adams, EN Cytrynbaum, F Tostevin, FC Collins, G Balgi, G Meacci, G Meacci, GF King, GF King, GG Szpiro, H Meinhardt, H Zhou, H Zhou, H Zhou, J Derr, J Elf, J Hattne, J Lutkenhaus, J Sung, JA Dix, JC Schaff, JS Zon van, JV Rodriguez, K Kruse, K Takahashi, K Takahashi, KC Huang, L Boulianne, L Ma, M Ander, M Fernandez-Suarez, M Gibson, M Howard, M Howard, M Loose, M Smoluchowski von, Masaru Tomita, MT Klann, N Ji, N Pavin, P Borowski, P Rangamani, RA Kerr, RJ Ellis, S Pichoff, S Schaub, S Wils, S Zimmerman, Satya Nanda Vel Arjunan, SB Albada van, SL Rowland, SNV Arjunan, SR Neves, SS Andrews, T Ideker, TG Bernhardt, U Resch-Genger, Y Shih, Y Shih, Y Zhang, Z Hu, Z Hu, Z Hu, Z Hu   +89 more
core   +3 more sources

Optimized Time–Frequency Analysis for Induction Motor Fault Detection Using Hybrid Differential Evolution and Deep Learning Techniques

International Journal of Adaptive Control and Signal Processing, EarlyView.
Workflow of the parameter optimization process for ITSC fault detection, applying Differential Evolution optimization and the Smooth Pseudo Wigner‐Ville Distribution for signal processing. The optimized parameters are then used in the failure identification pipeline, which combines the signal processing with a YOLO‐based architecture for fault severity
Rafael Martini Silva, Avyner Lorran de Oliveira Vitor, Marcelo Favoretto Castoldi, Alessandro Goedtel, Wesley Angelino Souza   +4 more
wiley   +1 more source

Local and global spontaneous calcium events regulate neurite outgrowth and onset of GABAergic phenotype during neural precursor differentiation [PDF]

, 2003
Neural stem cells can generate in vitro progenitors of the three main cell lineages found in the CNS. The signaling pathways underlying the acquisition of differentiated phenotypes in these cells are poorly understood.
Berridge, Michael J., Bootman, Martin D., Ciccolini, Francesca, Collins, Tony J., Lipp, Peter, Sudhoelter, Juliana   +5 more
core   +1 more source

Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts – from General Tissue Engineering to Cellular Agriculture

Advanced Biology, EarlyView.
Using supramolecular monomers, various hydrogel culture systems were formulated to culture protoplasts; including 2D, 2.5D, and 3D hydrogels. Depending on the culture platform, bioactive functionalization led to protoplast enlargement (2D and 2.5D) or plasmolysis (3D). This work shows the potential to modularly engineer synthetic platforms for cellular
Maritza M. Rovers, Erik J. Slootweg, Ferdinand C. O. Los, Patricia Y. W. Dankers   +3 more
wiley   +1 more source