Results 51 to 60 of about 197,424 (329)

Paeoniflorin Ameliorates Hyperprolactinemia-Induced Inhibition of Osteoblastogenesis by Suppressing the NF-κB Signaling Pathway

International Journal of Endocrinology, 2022
Hyperprolactinemia is a common endocrine disease in women of reproductive age. Research has shown that patients with hyperprolactinemia often have decreased bone mineral density and an increased risk of fractures.
Xiaohong Sun, Keda Zhu, Chengcheng Feng, Jie Zhu, Shuangshuang Chen, Wenkai Tang, Zhifang Wang, Long Xiao, Hong Li, Dechun Geng, Zhirong Wang   +10 more
doaj   +1 more source

BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network

, 2006
Several homeodomain (HD) proteins are critical for skeletal patterning and respond directly to BMP2 as an early step in bone formation. RUNX2, the earliest transcription factor proven essential for commitment to osteoblastogenesis, is also expressed in ...
Aberg, Acampora, Afzal, Amjad Javed, Andre J. van Wijnen, Aronow, Bae, Balint, Banerjee, Banerjee, Beanan, Bendall, Bryan, Cheng, Choi, Depew, Depew, Drissi, Drissi, Ducy, Ferrari, Fujita, Gary S. Stein, Gaur, Ghoul-Mazgar, Harris, Hassan, Hoffmann, Ichida, Ishii, Jane B. Lian, Janet L. Stein, Kim, Komori, Lallemand, Lee, Lengner, Lengner, Lundberg, Maria I. Morasso, Matthew Mandeville, McKeown, Miyama, Mohammad Q. Hassan, Nakashima, Newberry, Otto, Owen, Park, Pratap, Provot, Rahul S. Tare, Robinson, Robledo, Roca, Rosen, Ryoo, Satokata, Satokata, Semba, Shirakabe, Smith, Stricker, Suk Hee Lee, Ten Dijke, Vaes, van Gurp, Xu, Yoshizawa, Zaidi, Zaidi, Zambotti   +71 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Eucommia ulmoides Oliver polysaccharide alleviates glucocorticoid-induced osteoporosis by stimulating bone formation via ERK/BMP-2/SMAD signaling

Scientific Reports
Osteoporosis (OP) is a metabolic disease characterized by low bone mineral mass owing to osteoblast dysfunction. Eucommia ulmoides Oliver (EuO) is a Chinese herbal medicine traditionally used to treat OP.
Jiyu Song, Yongfeng Zhang, Xinghui Jin, Yanfeng Zhu, Yutong Li, Min Hu   +5 more
doaj   +1 more source

Osteoblast biology: developmental origin and interactive nature of osteoblasts

, 2021
Bone formation occurs throughout life to support growth and bone remodeling in response to mechanical forces, metabolic needs, and tissue repair upon injury. The physiological requirement for continuous bone renewal to accommodate remodeling necessitates recruitment, proliferation, and differentiation of bone-forming osteoblasts to counteract the ...
van der Eerden, Bram C.J., van Wijnen, André J.   +1 more
openaire   +1 more source

Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease [PDF]

, 2014
Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM ...
Blum B, Eriksen EF, Klein B, Lipton A, Mundy GR, Schmitt CP, Shay G   +6 more
core   +1 more source

Adipokines and Associations With Incident Osteoporotic Fracture in Patients With Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective We assessed whether circulating adipokines are associated with incident fractures in patients with rheumatoid arthritis (RA). Methods Three adipokines (adiponectin, leptin, and fibroblast growth factor [FGF]‐21) were measured using banked enrollment serum from participants in a longitudinal RA cohort.
Joshua F. Baker, Bryant R. England, Michael D. George, Hannah Brubeck, Brian Sauer, Aleksander Lenert, Punyasha Roul, Geoffrey M. Thiele, Ted R. Mikuls, Katherine D. Wysham   +9 more
wiley   +1 more source

Legumain is a paracrine regulator of osteoblast differentiation and mediates the inhibitory effect of TGF-β1 on osteoblast maturation

Frontiers in Endocrinology
Transforming growth factor-beta 1 (TGF-β1) is a critical regulator of skeletal homeostasis and has diverse effects on osteoblastogenesis. To date, the mechanisms behind the intriguing inhibitory effect of TGF-β1 on osteoblast maturation are not fully ...
Karl Martin Forbord, Ngoc Nguyen Lunde, Tatjana Bosnjak-Olsen, Harald Thidemann Johansen, Rigmor Solberg, Abbas Jafari   +5 more
doaj   +1 more source

Using UV laser surface treatment to modify the wettability characteristics of polyamide 6,6 and its effects on osteoblast cell activity [PDF]

, 2010
Lasers can be used to modify the surface characteristics of a number of different materials for many applications. This paper details the way in which a KrF 248 nm excimer laser can be utilized to surface pattern and whole area irradiate nylon 6,6.
Lawrence, Jonathan, Waugh, David
core   +1 more source

Composite Electrospun Fibers Containing Optimized B‐ and Cu‐Doped Bioactive Glass Sol‐Gel Particles for Potential Soft Tissue Engineering Applications

Advanced Engineering Materials, EarlyView.
This article describes the preparation and characterization of poly(ε‐caprolactone) electrospun composite fibers incorporating sol‐gel‐derived bioactive glass particles doped with B and Cu. Scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, Fourier‐transform infrared spectroscopy, contact angle, acellular bioactivity, mechanical and ...
Elisa Piatti, Marta Miola, Liliana Liverani, Paolo Sartori, Enrica Verné, Aldo R. Boccaccini   +5 more
wiley   +1 more source