Lactate-induced histone lactylation by p300 promotes osteoblast differentiation.
PLoS ONE, 2023 Lactate, which is synthesized as an end product by lactate dehydrogenase A (LDHA) from pyruvate during anaerobic glycolysis, has attracted attention for its energy metabolism and oxidant effects.
Erika Minami +7 more
doaj +2 more sources
Cell DiscoveryThe initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This differentiation process plays a crucial role in bone formation and homeostasis and is regulated by two intricate processes: cell ...
Siyu Zhu +3 more
doaj +2 more sources
Frontiers in Cell and Developmental Biology, 2020 Previous studies have found that circular RNA (circRNA) hsa_circ_0026827 plays a role during osteoblast differentiation, but the mechanism is unclear. The aim of this study was to illuminate the role of hsa_circ_0026827 in human dental pulp stem cells ...
Fang Ji +16 more
doaj +2 more sources
Bmp Induces Osteoblast Differentiation through both Smad4 and mTORC1 Signaling [PDF]
Molecular and Cellular Biology, 2016 The bone morphogenetic protein (Bmp) family of secreted molecules has been extensively studied in the context of osteoblast differentiation. However, the intracellular signaling cascades that mediate the osteoblastogenic function of Bmp have not been ...
Courtney M. Karner +2 more
semanticscholar +3 more sources
Differential expression of claudin family members during osteoblast and osteoclast differentiation: Cldn-1 is a novel positive regulator of osteoblastogenesis. [PDF]
PLoS ONE, 2014 Claudins (Cldns), a family of 27 transmembrane proteins, represent major components of tight junctions. Aside from functioning as tight junctions, Cldns have emerging roles as regulators of cell proliferation and differentiation. While Cldns are known to
Fatima Z Alshbool, Subburaman Mohan
doaj +3 more sources
Melatonin promotes osteoblast differentiation by regulating Osterix protein stability and expression
Scientific Reports, 2017 Although the biological role of melatonin in osteogenic differentiation has been suggested, the mechanism of osteoblast differentiation remains unclear. Thus, the present study investigated the underlying molecular mechanisms based on osteoblast-specific
Younho Han +3 more
doaj +2 more sources
Priming of mouse pre-osteoblasts with Interleukin-3 attenuates TNF-α-induced-inhibition of osteoblast differentiation [PDF]
BMC Musculoskeletal DisordersBackground In inflammatory bone loss disorders, such as rheumatoid arthritis and post-menopausal osteoporosis, TNF-α is an important effector cytokine that promotes osteoclastogenesis and inhibits osteoblastogenesis.
Vikrant Piprode +4 more
doaj +2 more sources
The Role of Osteocytes in Targeted Bone Remodeling: A Mathematical Model [PDF]
, 2013 Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. This
Ayati, Bruce P. +3 more
core +39 more sources
Geniposide ameliorates cholesterol accumulation and promotes osteoblast differentiation by mediating the GLP-1R/AMPK/SREBP2 pathway [PDF]
Journal of Orthopaedic Surgery and ResearchBackground Glucocorticoid (GC)-induced OP (GIOP) is a systemic metabolic bone disease with a high risk of fracture. Recently, lipid metabolic disorders, particularly hypercholesterolemia, have been correlated to the development of OP.
Wang Zhan +5 more
doaj +2 more sources
Correction: The role of vesicle trafficking genes in osteoblast differentiation and function. [PDF]
Sci RepZhu H, Su Y, Wang J, Wu JY.
europepmc +3 more sources