Results 181 to 190 of about 2,079,758 (368)

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

BMSC-derived exosomal lncRNA-ZFAS1 regulates the proliferation and differentiation of osteoblasts via the miR-9/IGF-1 signaling axis

Journal of Orthopaedic Surgery and Research
Background Osteoblast formation and function are essential for regulating bone disorders such as osteoporosis. Recent studies have confirmed that long non-coding RNAs (lncRNAs) from exosomes (ExOs) are involved in osteoblast proliferation and ...
Hui Sun, Yibin Liu, Haoran Wang, Zhiqiang Ma, Fang Xu, Xinlian Li, Gang Lv   +6 more
doaj   +1 more source

Regulation of Osteoblast Differentiation by Pasteurella Multocida Toxin (PMT): A Role for Rho GTPase in Bone Formation [PDF]

, 2004
Dympna Harmey, Gudrun Stenbeck, Catherine D. Nobes, Alistair J. Lax, Agamemnon E. Grigoriadis   +4 more
openalex   +1 more source

Myeloid‐derived growth factor (MYDGF) protects bone mass through inhibiting osteoclastogenesis and promoting osteoblast differentiation [PDF]

, 2022
Xiaoli Xu, Yixiang Li, Lingfeng Shi, Kaiyue He, Ying Sun, Yan Ding, Biying Meng, Jiajia Zhang, Lin Xiang, Jing Dong, Min Liu, Junxia Zhang, Lingwei Xiang, Guangda Xiang   +13 more
openalex   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone development [PDF]

, 2015
Xuchen Duan, Yurie Murata, Yanqiu Liu, Claudia M. Nicolae, Bjørn R. Olsen, Agnes D. Berendsen   +5 more
openalex   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

11β-Hydroxysteroid Dehydrogenase Expression and Glucocorticoid Synthesis Are Directed by a Molecular Switch during Osteoblast Differentiation [PDF]

, 2004
Marco Eijken, Martin Hewison, Mark S. Cooper, Frank H. de Jong, Hideki Chiba, Paul M. Stewart, André G. Uitterlinden, Huibert A. P. Pols, Johannes P.T.M. van Leeuwen   +8 more
openalex   +1 more source

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

Regulation And Mechanism Of ABCA8 On Osteoblast Senescence

International Dental Journal
Aim or purpose: To investigate the role of ATP-binding cassette subfamily A member 8 (ABCA8) in osteoblast senescence and its mechanistic contribution to osteoporosis. Materials and methods: Human bone marrow mesenchymal stem cells (hBMSCs) were isolated
Wenjing Yi, Buling Wu
doaj   +1 more source