Results 21 to 30 of about 2,079,758 (368)

Probiotic Propionibacterium freudenreichii MJ2 Enhances Osteoblast Differentiation and Mineralization by Increasing the OPG/RANKL Ratio

Microorganisms, 2021
Osteoblast differentiation is important for the development of bone and the maintenance of bone density. Propionibacterium freudenreichii is a probiotic with an anti-inflammatory property.
Jiah Yeom, Seongho Ma, Young-Hee Lim
doaj   +1 more source

Constitutive activation of Gli2 impairs bone formation in postnatal growing mice. [PDF]

PLoS ONE, 2013
Indian hedgehog (Ihh) signaling is indispensable for osteoblast differentiation during endochondral bone development in the mouse embryo.
Kyu Sang Joeng, Fanxin Long
doaj   +1 more source

Core-binding factor beta is required for osteoblast differentiation during fibula fracture healing

Journal of Orthopaedic Surgery and Research, 2021
Background Growing evidence has implicated core-binding factor beta (Cbfb) as a contributor to osteoblast differentiation, which plays a key role in fracture healing. Herein, we aimed to assess whether Cbfb affects osteoblast differentiation after fibula
Tuanmao Guo, Yanli Xing, Zhongning Chen, Xianhong Wang, Haiyun Zhu, Lan Yang, Yong Yan   +6 more
doaj   +1 more source

MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass

eLife, 2022
MAF1, a key repressor of RNA polymerase (pol) III-mediated transcription, has been shown to promote mesoderm formation in vitro. Here, we show that MAF1 plays a critical role in regulating osteoblast differentiation and bone mass. Global deletion of MAF1
Ellen Phillips, Naseer Ahmad, Li Sun, James Iben, Christopher J Walkey, Aleksandra Rusin, Tony Yuen, Clifford J Rosen, Ian M Willis, Mone Zaidi, Deborah L Johnson   +10 more
doaj   +1 more source

Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation. [PDF]

PLoS Genetics, 2010
Excessive accumulation of bone marrow adipocytes observed in senile osteoporosis or age-related osteopenia is caused by the unbalanced differentiation of MSCs into bone marrow adipocytes or osteoblasts. Several transcription factors are known to regulate
Yoshimi Tokuzawa, Ken Yagi, Yzumi Yamashita, Yutaka Nakachi, Itoshi Nikaido, Hidemasa Bono, Yuichi Ninomiya, Yukiko Kanesaki-Yatsuka, Masumi Akita, Hiromi Motegi, Shigeharu Wakana, Tetsuo Noda, Fred Sablitzky, Shigeki Arai, Riki Kurokawa, Toru Fukuda, Takenobu Katagiri, Christian Schönbach, Tatsuo Suda, Yosuke Mizuno, Yasushi Okazaki   +20 more
doaj   +1 more source

The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation

Frontiers in Cell and Developmental Biology, 2021
Receptor activator of NF-κB ligand (RANKL)-binding peptides inhibit bone resorption and were recently shown to activate bone formation. The stimulatory mechanism underlying bone formation associated with these peptides was explained as RANKL-reverse ...
Fatma Rashed, Fatma Rashed, Shingo Kamijyo, Yuri Shimizu, Yuna Hirohashi, Masud Khan, Yasutaka Sugamori, Ramachandran Murali, Kazuhiro Aoki   +8 more
doaj   +1 more source

Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation

Frontiers in Cell and Developmental Biology, 2020
With increasing life expectations, more and more patients suffer from fractures either induced by intensive sports or other bone-related diseases. The balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption is the basis
Q. Liu, Mao Li, Shiyi Wang, Zhousheng Xiao, Yuan-yuan Xiong, Guangwei Wang   +5 more
semanticscholar   +1 more source

Fibronectin regulates calvarial osteoblast differentiation [PDF]

Journal of Cell Science, 1996
ABSTRACT The secretion of fibronectin by differentiating osteoblasts and its accumulation at sites of osteogenesis suggest that fibronectin participates in bone formation. To test this directly, we determined whether fibronectin-cell interactions regulate progressive differentiation of cultured fetal rat calvarial osteoblasts.
A M, Moursi, C H, Damsky, J, Lull, D, Zimmerman, S B, Doty, S, Aota, R K, Globus   +6 more
openaire   +2 more sources

Protein palmitoylation regulates osteoblast differentiation through BMP-induced osterix expression. [PDF]

PLoS ONE, 2009
Osteoporosis is one of the most common diseases and can be treated by either anti-resorption drugs, anabolic drugs, or both. To search for anabolic drug targets for osteoporosis therapy, it is crucial to understand the biology of bone forming cells ...
Wai Fook Leong, Tielin Zhou, Gek Liang Lim, Baojie Li   +3 more
doaj   +1 more source

Regulation of osteoblast differentiation mediated by BMP, Notch, and CCN3/NOV

Japanese Dental Science Review, 2008
Osteoblasts originate from common progenitors, which are capable of differentiating into other mesenchymal cell lineages such as chondrocytes, myoblasts and adipocytes.
Akira Yamaguchi, Kei Sakamoto, Tokutarou Minamizato, Kenichi Katsube, Shoichi Nakanishi   +4 more
doaj   +1 more source