Results 31 to 40 of about 2,079,758 (368)

SLC38A2 provides proline and alanine to regulate postnatal bone mass accrual in mice

Frontiers in Physiology, 2022
Amino acids have recently emerged as important regulators of osteoblast differentiation and bone formation. Osteoblasts require a continuous supply of amino acids to sustain biomass production to fuel cell proliferation, osteoblast differentiation and ...
Leyao Shen, Yilin Yu, Courtney M. Karner, Courtney M. Karner, Courtney M. Karner   +4 more
doaj   +1 more source

Myocyte enhancer factor 2C: an osteoblast transcription factor identified by DMSO enhanced mineralization [PDF]

, 2011
Free to read on publisher website Rapid mineralization of cultured osteoblasts could be a useful characteristic in stem-cell mediated therapies for fracture and other orthopaedic problems. Dimethyl sulfoxide (DMSO) is a small amphipathic solvent molecule
Bacic-Welsh, Desa, Hobbs, Carl, Hutmacher, Dietmar, Morrison, Nigel, Stephens, Alexandre, Stephens, Sebastien, Woodruff, Mia   +6 more
core   +2 more sources

E3 Ubiquitin Ligase-Mediated Regulation of Osteoblast Differentiation and Bone Formation

Frontiers in Cell and Developmental Biology, 2021
The ubiquitin–proteasome system (UPS) is an essential pathway that regulates the homeostasis and function of intracellular proteins and is a crucial protein-degradation system in osteoblast differentiation and bone formation.
Jianlin Shen, Jianlin Shen, Bowen Fu, Yanfang Li, Yanjiao Wu, Hongxun Sang, Heshi Zhang, Haibin Lin, Huan Liu, Wenhua Huang, Wenhua Huang, Wenhua Huang   +11 more
doaj   +1 more source

Osteoblast differentiation and migration are regulated by Dynamin GTPase activity [PDF]

, 2014
Bone formation is controlled by osteoblasts but the signaling proteins that control osteoblast differentiation and function are still unclear. We examined if the dynamin GTPase, which is associated with actin remodeling and migration in other cells ...
Bruzzaniti, Angela, Eleniste, Pierre P., Huang, Su, Largura, Heather W., Wayakanon, Kornchanok   +4 more
core   +2 more sources

Hyaluronan inhibits BMP‐induced osteoblast differentiation [PDF]

FEBS Letters, 2015
Hyaluronan (HA), one of the major structural extracellular components in cartilage, regulates cellular responses via receptors such as CD44. However, the direct effects of HA on osteoblastic differentiation has not been studied in detail. Here, we investigated the effects of HA (molecular weight: 900–1200kDa) on osteoblastic differentiation that was ...
Kaneko, Keiko, Higuchi, Chikahisa, Kunugiza, Yasuo, Yoshida, Kiyoshi, Sakai, Takashi, Yoshikawa, Hideki, Nakata, Ken   +6 more
openaire   +2 more sources

Differential Iron Requirements for Osteoblast and Adipocyte Differentiation

JBMR Plus, 2021
ABSTRACT Bone marrow mesenchymal progenitor cells are precursors for various cell types including osteoblasts, adipocytes, and chondrocytes. The external environment and signals act to direct the pathway of differentiation. Importantly, situations such as aging and chronic kidney disease display alterations in the
Daniel F. Edwards, Christopher J. Miller, Arelis Quintana‐Martinez, Christian S. Wright, Matthew Prideaux, Gerald J. Atkins, William R. Thompson, Erica L. Clinkenbeard   +7 more
openaire   +4 more sources

Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy

Biology Open, 2019
Impaired osteoblast differentiation may result in bone metabolic diseases such as osteoporosis. It was reported recently that hedgehog (Hh) signaling and autophagy are two important regulators of bone differentiation.
Zhanying Hu, Bo Chen, Qiong Zhao
doaj   +1 more source

Detection of early osteogenic commitment in primary cells using Raman spectroscopy [PDF]

, 2017
Major challenges in the development of novel implant surfaces for artificial joints include osteoblast heterogeneity and the lack of a simple and sensitive in vitro assay to measure early osteogenic responses.
Clarkin, C E, Emery, R, Mahajan, S, Pitsillides, A A, Smith, S J   +4 more
core   +1 more source

Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway

eLife, 2022
Emerging evidence supports that osteogenic differentiation of skeletal progenitors is a key determinant of overall bone formation and bone mass. Despite extensive studies showing the function of mitogen-activated protein kinases (MAPKs) in osteoblast ...
Jung-Min Kim, Yeon-Suk Yang, Jaehyoung Hong, Sachin Chaugule, Hyonho Chun, Marjolein CH van der Meulen, Ren Xu, Matthew B Greenblatt, Jae-hyuck Shim   +8 more
doaj   +1 more source

VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited Runx2 transcription

Science Advances, 2020
VGLL4 relieves TEADs-mediated RUNX2 transcriptional inhibition by impairing TEADs-RUNX2 interaction. VGLL4 has been identified as a YAP inhibitor. However, the exact function of VGLL4 in bone development and bone homeostasis remains unclear.
Jinlong Suo, Xue Feng, Jiayi Li, Jinghui Wang, Zuoyun Wang, Lei Zhang, Weiguo Zou   +6 more
semanticscholar   +1 more source