Results 51 to 60 of about 2,079,758 (368)

METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling

International Journal of Molecular Sciences, 2019
Osteoblasts are crucial bone-building cells that maintain bone homeostasis, whereas inflammatory stimuli can inhibit osteogenesis and activate inflammatory response.
Yiwen Zhang, Xiaofei Gu, Di Li, Luhui Cai, Qiong Xu   +4 more
semanticscholar   +1 more source

IGFBP-2 Directly Stimulates Osteoblast Differentiation [PDF]

Journal of Bone and Mineral Research, 2014
ABSTRACT   Insulin-like growth factor binding protein 2 (IGFBP-2) is important for acquisition of normal bone mass in mice; however, the mechanism by which IGFBP-2 functions is not defined. These studies investigated the role of IGFBP-2 in stimulating osteoblast differentiation.
Gang, Xi, Christine, Wai, Victoria, DeMambro, Clifford J, Rosen, David R, Clemmons   +4 more
openaire   +2 more sources

Cyclophilin E (CypE) Functions as a Positive Regulator in Osteoblast Differentiation by Regulating the Transcriptional Activity of Runx2

Cells, 2023
Cyclophilin E (CypE) belongs to the cyclophilin family and exhibits peptidyl-prolyl cis-trans isomerase (PPIase) activity. It participates in various biological processes through the regulation of peptidyl-prolyl isomerization. However, the specific role
Meiyu Piao, Sung Ho Lee, Yuankuan Li, Joong-Kook Choi, Chang-Yeol Yeo, Kwang Youl Lee   +5 more
doaj   +1 more source

Temperature responsiveness of gilthead sea bream bone; an in vitro and in vivo approach [PDF]

, 2018
This study aimed to characterize the molecules involved in osteogenesis in seabream and establish using in vitro/in vivo approaches the responsiveness of selected key genes to temperature.
Capilla, Encarnacion, Costa, Rita, Gisbert, Enric, Gutierrez, Joaquim, Martins, Rute, Navarro, Isabel, Patricia Mateus, Ana, Power, Deborah M., Riera-Heredia, Natalia   +8 more
core   +3 more sources

Vitamin K2 stimulates MC3T3-E1 osteoblast differentiation and mineralization through autophagy induction

Molecular Medicine Reports, 2019
Vitamin K2 likely exerts its protective effects during osteoporosis by promoting osteoblast differentiation and mineralization. However, the precise mechanism remains to be fully elucidated.
Weiwei Li, Shaokun Zhang, Jie Liu, Yongyi Liu, Q. Liang   +4 more
semanticscholar   +1 more source

The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. [PDF]

, 2018
Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs).
Li, Shengwen Calvin, Li, Zhongjun, Ran, Qian, Wu, Jiang, Xiang, Yang, Zhang, Weiwei, Zhong, Jiang F   +6 more
core   +2 more sources

Involvement of Prolyl Hydroxylase Domain Protein in the Rosiglitazone-Induced Suppression of Osteoblast Differentiation. [PDF]

PLoS ONE, 2015
Rosiglitazone is a well-known anti-diabetic drug that increases insulin sensitivity via peroxisome proliferator-activated receptor γ (PPARγ) activation, but unfortunately it causes bone loss in animals and humans.
Ju-Hee Kang, Hyun Jeong Kwak, Hye-Eun Choi, Juyoung Kim, Sangmee Hong, Ok-Hee Kim, Byung Chul Oh, Hyae Gyeong Cheon   +7 more
doaj   +1 more source

JAK2-STAT5B pathway and osteoblast differentiation [PDF]

JAK-STAT, 2013
Osteoblast differentiation is a critical step in the maintenance of bone homeostasis. Osteoblast differentiation is generally maintained by growth hormone (GH) and various other endocrine and autocrine/paracrine factors. JAK2-STAT5B pathway is a central axis in the mechanism of GH signaling.
Darvin, Pramod, Joung, Youn Hee, Yang, Young Mok   +2 more
openaire   +2 more sources

SLC1A5 provides glutamine and asparagine necessary for bone development in mice

eLife, 2021
Osteoblast differentiation is sequentially characterized by high rates of proliferation followed by increased protein and matrix synthesis, processes that require substantial amino acid acquisition and production.
Deepika Sharma, Yilin Yu, Leyao Shen, Guo-Fang Zhang, Courtney M Karner   +4 more
doaj   +1 more source

FXR Activation Accelerates Early Phase of Osteoblast Differentiation Through COX-2-PGE₂-EP4 Axis in BMP-2-Induced Mouse Mesenchymal Stem Cells

Molecules
Farnesoid X receptor (FXR), a nuclear receptor, is expressed in calvaria and bone marrow stromal cells and plays a role in bone homeostasis. However, the mechanism of FXR-activated osteoblast differentiation remains unclear.
Ko Fujimori, Yusuke Iguchi, Yukiko Yamashita, Keigo Gohda, Naoki Teno   +4 more
doaj   +1 more source