Results 61 to 70 of about 2,079,758 (368)
Journal of Functional Biomaterials, 2023 Background: The events of bone formation and osteoblast/titanium (Ti) interactions may be affected by Hedgehog and Notch signalling pathways. Herein, we investigated the effects of modulation of these signalling pathways on osteoblast differentiation ...
Paola Gomes Souza +7 more
doaj +1 more source
Cellular & Molecular Biology Letters, 2019 Mechanical loading is an essential factor for bone formation. A previous study indicated that mechanical tensile strain of 2500 microstrain (με) at 0.5 Hz for 8 h promoted osteogenesis and corresponding mechanoresponsive microRNAs (miRs) were identified ...
Qiangcheng Zeng +8 more
semanticscholar +1 more source
Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx
Journal of Orthopaedic Surgery and Research, 2010 Bone formation is a complex developmental process involving the differentiation of mesenchymal stem cells to osteoblasts. Osteoblast differentiation occurs through a multi-step molecular pathway regulated by different transcription factors and signaling ...
Zhang Chi
doaj +1 more source
The PERK-EIF2α-ATF4 signaling branch regulates osteoblast differentiation and proliferation by PTH.
American Journal of Physiology. Endocrinology and Metabolism, 2019 Parathyroid hormone (PTH) and its related peptide (PTH-related peptide 1-34) are two of the Food and Drug Administration-approved bone-promoting drugs for age-related osteoporosis. Treatment with PTH stimulates bone formation.
Kefang Zhang +7 more
semanticscholar +1 more source
Osteoblast‐Targeted suppression of PPARγ increases osteogenesis through activation of mTOR signaling [PDF]
, 2013 Nuclear receptor peroxisome proliferator‐activated receptor‐γ (PPARγ) is an essential transcription factor for adipocyte differentiation. In mesenchymal stem cells, PPARγ has been assumed to play a negative role in osteoblastic differentiation, by ...
Hankenson, Kurt D. +5 more
core +1 more source
Indirect osteoblast differentiation by liposomal clodronate [PDF]
Journal of Cellular and Molecular Medicine, 2017 AbstractBisphosphonates impair function of osteoclasts and prevent bone resorption, the mechanism of which has been studied extensively. However, the possible effects of bisphosphonates on chondroblast differentiation and calcium deposition by osteoblasts have only been demonstrated recently.
Emi Okada +4 more
openaire +2 more sources
Molecules, 2016 Bone homeostasis is tightly regulated to balance bone formation and bone resorption. Many anabolic drugs are used as bone-targeted therapeutic agents for the promotion of osteoblast-mediated bone formation or inhibition of osteoclast-mediated bone ...
Hye-Min Kim +9 more
doaj +1 more source
Primary human osteoblasts in response to 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3. [PDF]
PLoS ONE, 2014 The most biologically active metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has well known direct effects on osteoblast growth and differentiation in vitro. The precursor 25-hydroxyvitamin D3 (25(OH)D3) can affect osteoblast function via conversion to
Karen van der Meijden +6 more
doaj +1 more source
International Journal of Molecular Sciences, 2019 Magnesium (Mg) is crucial for bone health. Low concentrations of Mg inhibit the activity of osteoblasts while promoting that of osteoclasts, with the final result of inducing osteopenia.
F. Mammoli +9 more
semanticscholar +1 more source
Cell Death and Differentiation, 2017 Recent studies have revealed robust metabolic changes during cell differentiation. Mitochondria, the organelles where many vital metabolic reactions occur, may play an important role.
Jing Gao +12 more
semanticscholar +1 more source